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SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients
Mone, Pasquale, Varzideh, Fahimeh, Jankauskas, Stanislovas S., Pansini, Antonella, Lombardi, Angela, Frullone, Salvatore, Santulli, Gaetano
Published in Hypertension (Dallas, Tex. 1979) (01.08.2022)
Published in Hypertension (Dallas, Tex. 1979) (01.08.2022)
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Journal Article
Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
Ferrannini, Ele, Baldi, Simona, Frascerra, Silvia, Astiarraga, Brenno, Heise, Tim, Bizzotto, Roberto, Mari, Andrea, Pieber, Thomas R., Muscelli, Elza
Published in Diabetes (New York, N.Y.) (01.05.2016)
Published in Diabetes (New York, N.Y.) (01.05.2016)
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Journal Article
Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 Diabetes
Daniele, Giuseppe, Xiong, Juan, Solis-Herrera, Carolina, Merovci, Aurora, Eldor, Roy, Tripathy, Devjit, DeFronzo, Ralph A., Norton, Luke, Abdul-Ghani, Muhammad
Published in Diabetes care (01.11.2016)
Published in Diabetes care (01.11.2016)
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Journal Article
Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
Bonner, Caroline, Kerr-Conte, Julie, Gmyr, Valéry, Queniat, Gurvan, Moerman, Ericka, Thévenet, Julien, Beaucamps, Cédric, Delalleau, Nathalie, Popescu, Iuliana, Malaisse, Willy J, Sener, Abdullah, Deprez, Benoit, Abderrahmani, Amar, Staels, Bart, Pattou, François
Published in Nature medicine (01.05.2015)
Published in Nature medicine (01.05.2015)
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Journal Article
Effects of dapagliflozin on human epicardial adipose tissue: modulation of insulin resistance, inflammatory chemokine production, and differentiation ability
Díaz-Rodríguez, Esther, Agra, Rosa M, Fernández, Ángel L, Adrio, Belén, García-Caballero, Tomás, González-Juanatey, José R, Eiras, Sonia
Published in Cardiovascular research (01.02.2018)
Published in Cardiovascular research (01.02.2018)
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Journal Article
Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis
Chun, Hye Jin, Kim, Eun Ran, Lee, Minyoung, Choi, Da Hyun, Kim, Soo Hyun, Shin, Eugene, Kim, Jin-Hong, Cho, Jin Won, Han, Dai Hoon, Cha, Bong-Soo, Lee, Yong-ho
Published in Metabolism, clinical and experimental (01.08.2023)
Published in Metabolism, clinical and experimental (01.08.2023)
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Journal Article
Renal Handling of Ketones in Response to Sodium–Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes
Ferrannini, Ele, Baldi, Simona, Frascerra, Silvia, Astiarraga, Brenno, Barsotti, Elisabetta, Clerico, Aldo, Muscelli, Elza
Published in Diabetes care (01.06.2017)
Published in Diabetes care (01.06.2017)
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Journal Article
SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria
Chino, Yukihiro, Samukawa, Yoshishige, Sakai, Soichi, Nakai, Yasuhiro, Yamaguchi, Jun-ichi, Nakanishi, Takeo, Tamai, Ikumi
Published in Biopharmaceutics & drug disposition (01.10.2014)
Published in Biopharmaceutics & drug disposition (01.10.2014)
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Journal Article
Effect of Sodium‐Glucose Cotransport‐2 Inhibitors on Blood Pressure in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis of 43 Randomized Control Trials With 22 528 Patients
Mazidi, Mohsen, Rezaie, Peyman, Gao, Hong‐Kai, Kengne, Andre Pascal
Published in Journal of the American Heart Association (25.05.2017)
Published in Journal of the American Heart Association (25.05.2017)
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Journal Article
Sodium‐glucose co‐transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects
Norton, Luke, Shannon, Christopher E., Fourcaudot, Marcel, Hu, Cheng, Wang, Niansong, Ren, Wei, Song, Jun, Abdul‐Ghani, Muhammad, DeFronzo, Ralph A., Ren, Jimmy, Jia, Weiping
Published in Diabetes, obesity & metabolism (01.09.2017)
Published in Diabetes, obesity & metabolism (01.09.2017)
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Journal Article
The Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Subjects With Type 2 Diabetes Mellitus
Sahasrabudhe, V., Terra, S. G., Hickman, A., Saur, D., Shi, H., O'Gorman, M., Zhou, Z., Cutler, D. L.
Published in Journal of clinical pharmacology (01.11.2017)
Published in Journal of clinical pharmacology (01.11.2017)
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Journal Article
Evaluation of renal and cardiovascular protection mechanisms of SGLT2 inhibitors: model-based analysis of clinical data
Hallow, K. Melissa, Greasley, Peter J., Helmlinger, Gabriel, Chu, Lulu, Heerspink, Hiddo J., Boulton, David W.
Published in American journal of physiology. Renal physiology (01.11.2018)
Published in American journal of physiology. Renal physiology (01.11.2018)
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Journal Article
Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes
Voigt, Jens Hohwü, Lauritsen, Katrine M., Pedersen, Steen Bønløkke, Hansen, Troels K., Møller, Niels, Jessen, Niels, Laurenti, Marcello C., Dalla Man, Chiara, Vella, Adrian, Gormsen, Lars C., Søndergaard, Esben
Published in Basic & clinical pharmacology & toxicology (01.05.2024)
Published in Basic & clinical pharmacology & toxicology (01.05.2024)
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Journal Article
Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects
Miao, Zhuang, Nucci, Gianluca, Amin, Neeta, Sharma, Raman, Mascitti, Vincent, Tugnait, Meera, Vaz, Alfin D., Callegari, Ernesto, Kalgutkar, Amit S.
Published in Drug metabolism and disposition (01.02.2013)
Published in Drug metabolism and disposition (01.02.2013)
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Journal Article
SGLT2 Inhibitors: From Molecular Mechanisms to Clinical Outcomes in Cardiology and Diabetology
Stielow, Marlena, Fijałkowski, Łukasz, Alaburda, Aidas, Grześk, Grzegorz, Grześk, Elżbieta, Nowaczyk, Jacek, Nowaczyk, Alicja
Published in Molecules (Basel, Switzerland) (25.07.2025)
Published in Molecules (Basel, Switzerland) (25.07.2025)
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Journal Article
Endogenous Glucose Production and Hormonal Changes in Response to Canagliflozin and Liraglutide Combination Therapy
Martinez, Robert, Al-Jobori, Hussein, Ali, Ali M., Adams, John, Abdul-Ghani, Muhammad, Triplitt, Curtis, DeFronzo, Ralph A., Cersosimo, Eugenio
Published in Diabetes (New York, N.Y.) (01.06.2018)
Published in Diabetes (New York, N.Y.) (01.06.2018)
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Journal Article
The Off-Target Effects, Electrolyte and Mineral Disorders of SGLT2i
Cianciolo, Giuseppe, De Pascalis, Antonio, Gasperoni, Lorenzo, Tondolo, Francesco, Zappulo, Fulvia, Capelli, Irene, Cappuccilli, Maria, La Manna, Gaetano
Published in Molecules (Basel, Switzerland) (15.06.2020)
Published in Molecules (Basel, Switzerland) (15.06.2020)
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Journal Article
Inhibition of sodium‐glucose cotransporter‐2 improves anaemia in mice and humans with sickle cell disease, and reduces infarct size in a murine stroke model
Wang, Jintao, Silaghi, Paul, Guo, Chiao, Harro, David, Eitzman, Daniel T.
Published in Journal of cellular and molecular medicine (01.09.2024)
Published in Journal of cellular and molecular medicine (01.09.2024)
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Journal Article