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Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection
Mohammadi, Kusha, Sleeman, Mark W., Boyapati, Anita, Bigdelou, Parnian, Geba, Gregory P., Fazio, Sergio
Published in Journal of lipid research (01.06.2024)
Published in Journal of lipid research (01.06.2024)
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Journal Article
GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates
Mastaitis, Jason W., Gomez, Daniel, Raya, José G., Li, Diana, Min, Soo, Stec, Michael, Kleiner, Sandra, McWilliams, Toya, Altarejos, Judith Y., Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W.
Published in Nature communications (13.05.2025)
Published in Nature communications (13.05.2025)
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Journal Article
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
Zhao, Tong-Jin, Liang, Guosheng, Li, Robert Lin, Xie, Xuefen, Sleeman, Mark W, Murphy, Andrew J, Valenzuela, David M, Yancopoulos, George D, Goldstein, Joseph L, Brown, Michael S
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
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Journal Article
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes
Zhou, Yi, Stevis, Panayiotis E., Cao, Jing, Ehrlich, George, Jones, Jennifer, Rafique, Ashique, Sleeman, Mark W., Olson, William C., Franklin, Matthew C.
Published in Nature communications (12.11.2024)
Published in Nature communications (12.11.2024)
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Journal Article
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial
Gonzalez Trotter, Dinko, Donahue, Stephen, Wynne, Chris, Ali, Shazia, Parasoglou, Prodromos, Boyapati, Anita, Mohammadi, Kusha, Musser, Bret J., Meier, Pretty, Mastaitis, Jason, Sleeman, Mark W., Glass, David J., Gasparino, Evelyn, Trejos, Jesus, Davis, John D., Hirshberg, Boaz, Pordy, Robert, Yancopoulos, George D., Herman, Gary A.
Published in Nature communications (13.05.2025)
Published in Nature communications (13.05.2025)
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Journal Article
The prevalence of low muscle mass associated with obesity in the USA
Murdock, Dana J., Wu, Ning, Grimsby, Joseph S., Calle, Roberto A., Donahue, Stephen, Glass, David J., Sleeman, Mark W., Sanchez, Robert J.
Published in Skeletal muscle (21.12.2022)
Published in Skeletal muscle (21.12.2022)
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Journal Article
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver
Su, Qi, Kim, Sun Y., Adewale, Funmi, Zhou, Ye, Aldler, Christina, Ni, Min, Wei, Yi, Burczynski, Michael E., Atwal, Gurinder S., Sleeman, Mark W., Murphy, Andrew J., Xin, Yurong, Cheng, Xiping
Published in iScience (19.11.2021)
Published in iScience (19.11.2021)
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Journal Article
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid, Alfonso, Liu, Zhong-Wu, Andrews, Zane B., Shanabrough, Marya, Borok, Erzsebet, Elsworth, John D., Roth, Robert H., Sleeman, Mark W., Picciotto, Marina R., Tschöp, Matthias H., Gao, Xiao-Bing, Horvath, Tamas L.
Published in The Journal of clinical investigation (01.12.2006)
Published in The Journal of clinical investigation (01.12.2006)
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Journal Article
Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice
Jois, Tara, Howard, Victor, Youngs, Kristina, Cowley, Michael A., Sleeman, Mark W.
Published in PloS one (19.12.2016)
Published in PloS one (19.12.2016)
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Journal Article
Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin
López, Miguel, Lage, Ricardo, Saha, Asish K., Pérez-Tilve, Diego, Vázquez, María J., Varela, Luis, Sangiao-Alvarellos, Susana, Tovar, Sulay, Raghay, Kawtar, Rodríguez-Cuenca, Sergio, Deoliveira, Rosangela M., Castañeda, Tamara, Datta, Rakesh, Dong, Jesse Z., Culler, Michael, Sleeman, Mark W., Álvarez, Clara V., Gallego, Rosalía, Lelliott, Christopher J., Carling, David, Tschöp, Matthias H., Diéguez, Carlos, Vidal-Puig, Antonio
Published in Cell metabolism (01.05.2008)
Published in Cell metabolism (01.05.2008)
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Journal Article
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
Harvey, Natasha L, Srinivasan, R Sathish, Dillard, Miriam E, Johnson, Nicole C, Witte, Marlys H, Boyd, Kelli, Sleeman, Mark W, Oliver, Guillermo
Published in Nature genetics (01.10.2005)
Published in Nature genetics (01.10.2005)
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Journal Article
Ghrelin controls hippocampal spine synapse density and memory performance
Diano, Sabrina, Farr, Susan A, Benoit, Stephen C, McNay, Ewan C, da Silva, Ivaldo, Horvath, Balazs, Gaskin, F Spencer, Nonaka, Naoko, Jaeger, Laura B, Banks, William A, Morley, John E, Pinto, Shirly, Sherwin, Robert S, Xu, Lin, Yamada, Kelvin A, Sleeman, Mark W, Tschöp, Matthias H, Horvath, Tamas L
Published in Nature neuroscience (01.03.2006)
Published in Nature neuroscience (01.03.2006)
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Journal Article
Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance
Adam, Rene C., Mintah, Ivory J., Alexa-Braun, Corey A., Shihanian, Lisa M., Lee, Joseph S., Banerjee, Poulabi, Hamon, Sara C., Kim, Hye In, Cohen, Jonathan C., Hobbs, Helen H., Van Hout, Cristopher, Gromada, Jesper, Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W., Gusarova, Viktoria
Published in Journal of lipid research (01.09.2020)
Published in Journal of lipid research (01.09.2020)
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Journal Article
The Ghrelin/GOAT System Regulates Obesity-Induced Inflammation in Male Mice
Harvey, Rebecca E., Howard, Victor G., Lemus, Moyra B., Jois, Tara, Andrews, Zane B., Sleeman, Mark W.
Published in Endocrinology (Philadelphia) (01.07.2017)
Published in Endocrinology (Philadelphia) (01.07.2017)
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Journal Article
Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice
Jois, Tara, Chen, Weiyi, Howard, Victor, Harvey, Rebecca, Youngs, Kristina, Thalmann, Claudia, Saha, Pradip, Chan, Lawrence, Cowley, Michael A., Sleeman, Mark W.
Published in Molecular metabolism (Germany) (01.11.2017)
Published in Molecular metabolism (Germany) (01.11.2017)
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Journal Article
Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity
Mustafa, Tomris, Li, Qun, Kelly, Lauren E., Gibbon, Anne, Ryan, Irwin, Roffey, Keisha, Simonds, Stephanie, Cowley, Michael A., Sleeman, Mark W.
Published in PloS one (04.04.2019)
Published in PloS one (04.04.2019)
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Journal Article
Ghrelin-Related Peptides Exert Protective Effects in the Cerebral Circulation of Male Mice Through a Nonclassical Ghrelin Receptor(s)
Ku, Jacqueline M., Andrews, Zane B., Barsby, Tom, Reichenbach, Alex, Lemus, Moyra B., Drummond, Grant R., Sleeman, Mark W., Spencer, Sarah J., Sobey, Christopher G., Miller, Alyson A.
Published in Endocrinology (Philadelphia) (01.01.2015)
Published in Endocrinology (Philadelphia) (01.01.2015)
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Journal Article
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
Pfluger, Paul T., Kirchner, Henriette, Günnel, Susanne, Schrott, Brigitte, Perez-Tilve, Diego, Fu, Sheng, Benoit, Stephen C., Horvath, Tamas, Joost, Hans-Georg, Wortley, Katherine E., Sleeman, Mark W., Tschöp, Matthias H.
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2008)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2008)
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Journal Article
Genetic Deletion of Ghrelin Does Not Decrease Food Intake but Influences Metabolic Fuel Preference
Wortley, Katherine E., Anderson, Keith D., Garcia, Karen, Murray, Jane D., Malinova, Lubomira, Liu, Rong, Moncrieffe, Marshena, Thabet, Karen, Cox, Hilary J., Yancopoulos, George D., Wiegand, Stanley J., Sleeman, Mark W., Vagelos, P. Roy
Published in Proceedings of the National Academy of Sciences - PNAS (25.05.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (25.05.2004)
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Journal Article