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From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
Veit, Gudio, Avramescu, Radu G., Chiang, Annette N., Houck, Scott A., Cai, Zhiwei, Peters, Kathryn W., Hong, Jeong S., Pollard, Harvey B., Guggino, William B., Balch, William E., Skach, William R., Cutting, Garry R., Frizzell, Raymond A., Sheppard, David N., Cyr, Douglas M., Sorscher, Eric J., Brodsky, Jeffrey L., Lukacs, Gergely L.
Published in Molecular biology of the cell (01.02.2016)
Published in Molecular biology of the cell (01.02.2016)
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Journal Article
Alteration of protein function by a silent polymorphism linked to tRNA abundance
Kirchner, Sebastian, Cai, Zhiwei, Rauscher, Robert, Kastelic, Nicolai, Anding, Melanie, Czech, Andreas, Kleizen, Bertrand, Ostedgaard, Lynda S., Braakman, Ineke, Sheppard, David N., Ignatova, Zoya
Published in PLoS biology (16.05.2017)
Published in PLoS biology (16.05.2017)
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Journal Article
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia
Li, Hongyu, Valkenier, Hennie, Judd, Luke W., Brotherhood, Peter R., Hussain, Sabir, Cooper, James A., Jurček, Ondřej, Sparkes, Hazel A., Sheppard, David N., Davis, Anthony P.
Published in Nature chemistry (01.01.2016)
Published in Nature chemistry (01.01.2016)
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Journal Article
Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR
Bose, Samuel J., Bijvelds, Marcel J. C., Wang, Yiting, Liu, Jia, Cai, Zhiwei, Bot, Alice G. M., de Jonge, Hugo R., Sheppard, David N.
Published in American journal of physiology. Lung cellular and molecular physiology (01.07.2019)
Published in American journal of physiology. Lung cellular and molecular physiology (01.07.2019)
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Journal Article
Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease
Kelly, Jennifer, Al-Rammahi, Miran, Daly, Kristian, Flanagan, Paul K., Urs, Arun, Cohen, Marta C., di Stefano, Gabriella, Bijvelds, Marcel J. C., Sheppard, David N., de Jonge, Hugo R., Seidler, Ursula E., Shirazi-Beechey, Soraya P.
Published in Scientific reports (21.04.2022)
Published in Scientific reports (21.04.2022)
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Journal Article
In vitro platform to model the function of ionocytes in the human airway epithelium
Vilà-González, Marta, Pinte, Laetitia, Fradique, Ricardo, Causa, Erika, Kool, Heleen, Rodrat, Mayuree, Morell, Carola Maria, Al-Thani, Maha, Porter, Linsey, Guo, Wenrui, Maeshima, Ruhina, Hart, Stephen L., McCaughan, Frank, Granata, Alessandra, Sheppard, David N., Floto, R. Andres, Rawlins, Emma L., Cicuta, Pietro, Vallier, Ludovic
Published in Respiratory research (25.04.2024)
Published in Respiratory research (25.04.2024)
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Journal Article
Mouse models of cystic fibrosis: Phenotypic analysis and research applications
Wilke, Martina, Buijs-Offerman, Ruvalic M., Aarbiou, Jamil, Colledge, William H., Sheppard, David N., Touqui, Lhousseine, Bot, Alice, Jorna, Huub, De Jonge, Hugo R., Scholte, Bob J.
Published in Journal of cystic fibrosis (01.06.2011)
Published in Journal of cystic fibrosis (01.06.2011)
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Journal Article
Nonprotonophoric Electrogenic Cl− Transport Mediated by Valinomycin-like Carriers
Wu, Xin, Judd, Luke W., Howe, Ethan N.W., Withecombe, Anne M., Soto-Cerrato, Vanessa, Li, Hongyu, Busschaert, Nathalie, Valkenier, Hennie, Pérez-Tomás, Ricardo, Sheppard, David N., Jiang, Yun-Bao, Davis, Anthony P., Gale, Philip A.
Published in Chem (07.07.2016)
Published in Chem (07.07.2016)
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Journal Article
Residual function of cystic fibrosis mutants predicts response to small molecule CFTR modulators
Han, Sangwoo T., Rab, Andras, Pellicore, Matthew J., Davis, Emily F., McCague, Allison F., Evans, Taylor A., Joynt, Anya T., Lu, Zhongzhou, Cai, Zhiwei, Raraigh, Karen S., Hong, Jeong S., Sheppard, David N., Sorscher, Eric J., Cutting, Garry R.
Published in JCI insight (26.07.2018)
Published in JCI insight (26.07.2018)
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Journal Article
Managing an ageing cystic fibrosis population: challenges and priorities
Frost, Freddy J., Peckham, Daniel G., Felton, Imogen C., Snowball, Joanna E., Gray, Robert D., Jones, Andrew M., Simmonds, Nicholas J., Lord, Robert W., Lip, Gregory Y.H., Chandler, Hannah, Murphy, Kevin, Downey, Damian G., Sheppard, David N., Davies, Jane C., Bull, Jane, Sommer, Paula, Cupid, Belinda, Allen, Lucy, Duckers, Jamie
Published in European respiratory review (01.04.2025)
Published in European respiratory review (01.04.2025)
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Journal Article
Experimental pharmacology in precision medicine
Urbaniak, Alicja, Thummel, Kenneth E., Alade, Ayoade N., Rettie, Allan E., Prasad, Bhagwat, De Nicolò, Amedeo, Martin, Jennifer H., Sheppard, David N., Jarvis, Michael F.
Published in Pharmacology research & perspectives (01.12.2023)
Published in Pharmacology research & perspectives (01.12.2023)
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Journal Article
Differential Sensitivity of the Cystic Fibrosis (CF)-associated Mutants G551D and G1349D to Potentiators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl– Channel
Cai, Zhiwei, Taddei, Alessandro, Sheppard, David N.
Published in The Journal of biological chemistry (27.01.2006)
Published in The Journal of biological chemistry (27.01.2006)
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Journal Article
Revertant Mutants G550E and 4RK Rescue Cystic Fibrosis Mutants in the First Nucleotide-Binding domain of CFTR by Different Mechanisms
Roxo-Rosa, Mónica, Xu, Zhe, Schmidt, André, Neto, Mário, Cai, Zhiwei, Soares, Cláudio M., Sheppard, David N., Amaral, Margarida D.
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
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Journal Article
Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis
Cai, Zhi-wei, Liu, Jia, Li, Hong-yu, Sheppard, David N
Published in Acta pharmacologica Sinica (01.06.2011)
Published in Acta pharmacologica Sinica (01.06.2011)
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Journal Article