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Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study
Gonzales, Emmanuel, Hardikar, Winita, Stormon, Michael, Baker, Alastair, Hierro, Loreto, Gliwicz, Dorota, Lacaille, Florence, Lachaux, Alain, Sturm, Ekkehard, Setchell, Kenneth D R, Kennedy, Ciara, Dorenbaum, Alejandro, Steinmetz, Jana, Desai, Nirav K, Wardle, Andrew J, Garner, Will, Vig, Pamela, Jaecklin, Thomas, Sokal, Etienne M, Jacquemin, Emmanuel
Published in The Lancet (British edition) (30.10.2021)
Published in The Lancet (British edition) (30.10.2021)
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Journal Article
Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice
Miethke, Alexander G., Zhang, Wujuan, Simmons, Julia, Taylor, Amy E., Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G., Lages, Celine S., Nkinin, Stephenson, Keller, Bradley T., Setchell, Kenneth D.R.
Published in Hepatology (Baltimore, Md.) (01.02.2016)
Published in Hepatology (Baltimore, Md.) (01.02.2016)
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Journal Article
Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
Setchell, Kenneth DR, Brown, Nadine M, Zhao, Xueheng, Lindley, Stephanie L, Heubi, James E, King, Eileen C, Messina, Mark J
Published in The American journal of clinical nutrition (01.11.2011)
Published in The American journal of clinical nutrition (01.11.2011)
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Journal Article
Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction
Zhao, Xueheng, Setchell, Kenneth DR, Huang, Rong, Mallawaarachchi, Indika, Ehsan, Lubaina, Dobrzykowski III, Edward, Zhao, Junfang, Syed, Sana, Ma, Jennie Z, Iqbal, Najeeha T, Iqbal, Junaid, Sadiq, Kamran, Ahmed, Sheraz, Haberman, Yael, Denson, Lee A, Asad Ali, Syed, Moore, Sean R
Published in The Journal of nutrition (01.12.2021)
Published in The Journal of nutrition (01.12.2021)
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Journal Article
The Fanconi Anemia Pathway Inhibits mTOR Signaling and Prevents Accelerated Translation in Head and Neck Cancer Cells
Ruffolo, Bianca, Vicente-Muñoz, Sara, Mehta, Khyati Y., Rivera-Cruz, Cosette M., Zhao, Xueheng, Romick, Lindsey, Setchell, Kenneth D. R., Lane, Adam, Wells, Susanne I.
Published in Cancers (06.08.2025)
Published in Cancers (06.08.2025)
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Journal Article
Properties of Neurons Derived from Induced Pluripotent Stem Cells of Gaucher Disease Type 2 Patient Fibroblasts: Potential Role in Neuropathology
Sun, Ying, Florer, Jane, Mayhew, Christopher N., Jia, Zhanfeng, Zhao, Zhiying, Xu, Kui, Ran, Huimin, Liou, Benjamin, Zhang, Wujuan, Setchell, Kenneth D. R., Gu, Jianguo, Grabowski, Gregory A.
Published in PloS one (30.03.2015)
Published in PloS one (30.03.2015)
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Journal Article
PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases
Zhao, Xiangli, Lin, Yi, Liou, Benjamin, Fu, Wenyu, Jian, Jinlong, Fannin, Venette, Zhang, Wujuan, Setchell, Kenneth D. R., Grabowski, Gregory A., Sun, Ying, Liu, Chuan-ju
Published in Proceedings of the National Academy of Sciences - PNAS (03.01.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (03.01.2023)
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Journal Article
Rates of substance and polysubstance use through universal maternal testing at the time of delivery
Smith, Brittany L., Hall, Eric S., McAllister, Jennifer M., Marcotte, Michael P., Setchell, Kenneth D. R., Megaraj, Vandana, Jimenez, Kristine L., John Winhusen, T., Wexelblatt, Scott L.
Published in Journal of perinatology (01.08.2022)
Published in Journal of perinatology (01.08.2022)
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Journal Article
Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease
Lin, Yi, Zhao, Xiangli, Liou, Benjamin, Fannin, Venette, Zhang, Wujuan, Setchell, Kenneth D R, Wang, Xiaohong, Pan, Dao, Grabowski, Gregory A, Liu, Chuan-ju, Sun, Ying
Published in Human molecular genetics (07.10.2024)
Published in Human molecular genetics (07.10.2024)
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Journal Article
Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids
Kohli, Rohit, Bradley, David, Setchell, Kenneth D., Eagon, J. Christopher, Abumrad, Nada, Klein, Samuel
Published in The journal of clinical endocrinology and metabolism (01.04.2013)
Published in The journal of clinical endocrinology and metabolism (01.04.2013)
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Journal Article
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy
Myronovych, Andriy, Bhattacharjee, Jashdeep, Salazar-Gonzalez, Rosa-Maria, Tan, Brandon, Mowery, Sarah, Ferguson, Danielle, Ryan, Karen K., Zhang, Wujuan, Zhao, Xueheng, Oehrle, Melissa, Setchell, Kenneth D. R., Seeley, Randy J., Sandoval, Darleen A., Kohli, Rohit
Published in American journal of physiology: Gastrointestinal and liver physiology (01.12.2020)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.12.2020)
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Journal Article
Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight‐loss‐independent manner
Myronovych, Andriy, Kirby, Michelle, Ryan, Karen K., Zhang, Wujuan, Jha, Pinky, Setchell, Kenneth DR, Dexheimer, Phillip J., Aronow, Bruce, Seeley, Randy J., Kohli, Rohit
Published in Obesity (Silver Spring, Md.) (01.02.2014)
Published in Obesity (Silver Spring, Md.) (01.02.2014)
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Journal Article