Vyzkoušejte nový nástroj s podporou AI
Summon Research Assistant
BETA
Chemical probes and drug leads from advances in synthetic planning and methodology
Gerry, Christopher J., Schreiber, Stuart L.
Published in Nature reviews. Drug discovery (01.05.2018)
Published in Nature reviews. Drug discovery (01.05.2018)
Get full text
Journal Article
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.
Published in Cell (16.01.2014)
Published in Cell (16.01.2014)
Get full text
Journal Article
Direct control of mitochondrial function by mTOR
Ramanathan, Arvind, Schreiber, Stuart L
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2009)
Get full text
Journal Article
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T.
Published in Nature (London) (09.11.2017)
Published in Nature (London) (09.11.2017)
Get full text
Journal Article
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
Zou, Yilong, Henry, Whitney S., Ricq, Emily L., Graham, Emily T., Phadnis, Vaishnavi V., Maretich, Pema, Paradkar, Sateja, Boehnke, Natalie, Deik, Amy A., Reinhardt, Ferenc, Eaton, John K., Ferguson, Bryan, Wang, Wenyu, Fairman, Joshua, Keys, Heather R., Dančík, Vlado, Clish, Clary B., Clemons, Paul A., Hammond, Paula T., Boyer, Laurie A., Weinberg, Robert A., Schreiber, Stuart L.
Published in Nature (London) (24.09.2020)
Published in Nature (London) (24.09.2020)
Get full text
Journal Article
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.
Published in Nature communications (08.04.2019)
Published in Nature communications (08.04.2019)
Get full text
Journal Article
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.
Published in Nature chemical biology (01.05.2020)
Published in Nature chemical biology (01.05.2020)
Get full text
Journal Article
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L
Published in Science (American Association for the Advancement of Science) (17.01.2014)
Published in Science (American Association for the Advancement of Science) (17.01.2014)
Get full text
Journal Article
Phosphorylation-Inducing Chimeric Small Molecules
Siriwardena, Sachini U, Munkanatta Godage, Dhanushka N. P, Shoba, Veronika M, Lai, Sophia, Shi, Mengchao, Wu, Peng, Chaudhary, Santosh K, Schreiber, Stuart L, Choudhary, Amit
Published in Journal of the American Chemical Society (19.08.2020)
Published in Journal of the American Chemical Society (19.08.2020)
Get full text
Journal Article
Metabolomic adaptations and correlates of survival to immune checkpoint blockade
Li, Haoxin, Bullock, Kevin, Gurjao, Carino, Braun, David, Shukla, Sachet A., Bossé, Dominick, Lalani, Aly-Khan A., Gopal, Shuba, Jin, Chelsea, Horak, Christine, Wind-Rotolo, Megan, Signoretti, Sabina, McDermott, David F., Freeman, Gordon J., Van Allen, Eliezer M., Schreiber, Stuart L., Stephen Hodi, F., Sellers, William R., Garraway, Levi A., Clish, Clary B., Choueiri, Toni K., Giannakis, Marios
Published in Nature communications (25.09.2019)
Published in Nature communications (25.09.2019)
Get full text
Journal Article
Organic synthesis toward small-molecule probes and drugs
Schreiber, Stuart L
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Get full text
Journal Article
Structure–activity relationships of GPX4 inhibitor warheads
Eaton, John K., Furst, Laura, Cai, Luke L., Viswanathan, Vasanthi S., Schreiber, Stuart L.
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
Published in Bioorganic & medicinal chemistry letters (01.12.2020)
Get full text
Journal Article
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Published in Nature (London) (14.07.2011)
Published in Nature (London) (14.07.2011)
Get full text
Journal Article
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
Yu, Channing, Mannan, Aristotle M, Yvone, Griselda Metta, Ross, Kenneth N, Zhang, Yan-Ling, Marton, Melissa A, Taylor, Bradley R, Crenshaw, Andrew, Gould, Joshua Z, Tamayo, Pablo, Weir, Barbara A, Tsherniak, Aviad, Wong, Bang, Garraway, Levi A, Shamji, Alykhan F, Palmer, Michelle A, Foley, Michael A, Winckler, Wendy, Schreiber, Stuart L, Kung, Andrew L, Golub, Todd R
Published in Nature biotechnology (01.04.2016)
Published in Nature biotechnology (01.04.2016)
Get full text
Journal Article