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Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study
Friedrich, Christian, Francke, Klaus, Gashaw, Isabella, Scheerans, Christian, Klein, Stefan, Fels, Lueder, Smith, Jaclyn A., Hummel, Thomas, Morice, Alyn
Published in Clinical pharmacokinetics (01.08.2022)
Published in Clinical pharmacokinetics (01.08.2022)
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Journal Article
Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis
Hilpert, Jan, Groettrup-Wolfers, Esther, Kosturski, Hristiyan, Bennett, Laura, Barnes, Catriona L. K., Gude, Kerstin, Gashaw, Isabella, Reif, Stefanie, Steger-Hartmann, Thomas, Scheerans, Christian, Solms, Alexander, Rottmann, Antje, Mao, Guangping, Chapron, Charles
Published in Drugs in R&D (01.09.2023)
Published in Drugs in R&D (01.09.2023)
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Journal Article
Compliance assessment of ambulatory Alzheimer patients to aid therapeutic decisions by healthcare professionals
Schwalbe, Oliver, Scheerans, Christian, Freiberg, Ines, Schmidt-Pokrzywniak, Andrea, Stang, Andreas, Kloft, Charlotte
Published in BMC health services research (09.08.2010)
Published in BMC health services research (09.08.2010)
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Journal Article
Polycystic ovary syndrome and elevated body mass index independently increase type 2 diabetes risk with obesity-mediated risk dominating: a real-world data analysis of US patients
Sharafutdinov, Konstantin, Hilpert, Jan, Burghaus, Rolf, Diedrich, Christian, Lippert, Jörg, Scheerans, Christian, Schaper, Steffen
Published in Fertility and sterility (12.09.2025)
Published in Fertility and sterility (12.09.2025)
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Journal Article
Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending‐dose study in healthy young men
Friedrich, Christian, Singh, Dave, Francke, Klaus, Klein, Stefan, Hetzel, Terence, Zolk, Oliver, Gashaw, Isabella, Scheerans, Christian, Morice, Alyn
Published in British journal of clinical pharmacology (01.08.2024)
Published in British journal of clinical pharmacology (01.08.2024)
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Journal Article
Meta-analysis of preclinical measures of efficacy in immune checkpoint blockade therapies and comparison to clinical efficacy estimates
Tenorio-Pedraza, Juan Miguel, Lippert, Jörg, Burghaus, Rolf, Scheerans, Christian
Published in Translational medicine communications (15.08.2023)
Published in Translational medicine communications (15.08.2023)
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Journal Article
Novel aldo-keto reductase 1C3 inhibitor affects androgen metabolism but not ovarian function in healthy women: a phase 1 study
Gashaw, Isabella, Reif, Stefanie, Wiesinger, Herbert, Kaiser, Andreas, Zollmann, Frank S, Scheerans, Christian, Grevel, Joachim, Piraino, Paolo, Seidel, Henrik, Peters, Michaele, Rottmann, Antje, Rohde, Beate, Arlt, Wiebke, Hilpert, Jan
Published in European journal of endocrinology (10.07.2023)
Published in European journal of endocrinology (10.07.2023)
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Journal Article
Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm
Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., Graaf, Piet H., Kierzek, Andrzej M.
Published in Clinical pharmacology and therapeutics (01.03.2021)
Published in Clinical pharmacology and therapeutics (01.03.2021)
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Journal Article
Abstract 2791: Physiologically based pharmacokinetic modeling and simulations to estimate the efficacious dose of the CEACAM6 function-blocking antibody BAY 1834942
Wittemer-Rump, Sabine, Niederalt, Christoph, Willuda, Joerg, Trautwein, Mark, Luetke-Eversloh, Merlin, Doecke, Wolf-Dietrich, Guenther, Clemens, Scheerans, Christian
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
In vitro pharmacodynamic models to determine the effect of antibacterial drugs
Gloede, Julia, Scheerans, Christian, Derendorf, Hartmut, Kloft, Charlotte
Published in Journal of antimicrobial chemotherapy (01.02.2010)
Published in Journal of antimicrobial chemotherapy (01.02.2010)
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Journal Article
Concentration–response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium
Scheerans, Christian, Wicha, Sebastian G., Michael, Julia, Derendorf, Hartmut, Kloft, Charlotte
Published in International journal of antimicrobial agents (01.01.2015)
Published in International journal of antimicrobial agents (01.01.2015)
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Journal Article
Abstract CT276: Preliminary analysis of pharmacokinetic (PK) and target engagement biomarkers from a first in human phase 1 study of immunomodulatory aryl hydrocarbon receptor (AhR) inhibitor BAY2416964
Papadopoulos, Kyriakos, Cecchini, Michael, Lopez, Juanita S., Jäger, Dirk, Chung, Ki Young, Platten, Michael, Prinz, Florian, Ishii, Yuko, Schaer, David, Gutcher, Ilona, Leder, Gabriele, Pencheva, Radost, Wagener, Thomas, Scheerans, Christian, Zieschang, Carsten, Wagner, Andrea, Stamatelos, Spyros, Dumbrava, Ecaterina
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article