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A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia
Xie, Dongmei, Feng, Zhihui, Yang, Wen, Wang, Yacan, Li, Renxia, Zhang, Shiqi, Zhou, Zeping
Published in Cellular immunology (01.09.2023)
Published in Cellular immunology (01.09.2023)
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Journal Article
Phase 1 trial of HCB101, a novel Fc-based anti-SIRPα-CD47 fusion protein, in subjects with advanced cancers
Sun, David, Zhang, Vivien, Edenfield, William Jeffery, Iannotti, Nicholas, Zhang, Tian, Chang, Peter, Cheng, Wei-Hong, Zhang, Jian, Tong, Xiangmin, Zhang, Yan, Hsieh, Chihyi, Luk, Alvin, Lin, Chia-Chi
Published in Journal of clinical oncology (01.06.2025)
Published in Journal of clinical oncology (01.06.2025)
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Journal Article
Preliminary results of a first-in-human phase I dtudy of IMM01, SIRPα Fc protein in patients with relapsed or refractory lymphoma
Sun, Mingyuan, Qi, Junyuan, Zheng, Weiwei, Song, Lin, Jiang, Bo, Wang, Zhenzhen, Huang, Cheng, Tian, Wenzhi, Qiu, Lugui
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Journal Article
650 Neoadjuvant ezabenlimab or pembrolizumab in combination with an anti-SIRPα antibody in resectable colorectal cancer
Lucas, Natalie, Venturini, Nicholas, Hegde, Samarth, Mattiuz, Raphaël, Hennequin, Clotilde, Berichel, Jessica Le, Chin, Theodore, Reid, Amanda, Troncoso, Leanna, Greenwald, David, Grinspan, Ari, Itzkowitz, Steve, Lucas, Aimee L, Zalkin, Dana, Ang, Celina, Acuna-Villaorduna, Ana, Kozuch, Peter, Khaitov, Sergey, Ky-Miyasaka, Alex, Sarpel, Umut, Steinhagen, Randolph, Sylla, Patricia, Kretschmar, Gunther, Zhu, Zheng, Harpaz, Noam, Liu, Qingqing, Paulsen, John, Wang, Xintong, Ward, Stephen, Doroshow, Deborah, Polydorides, Alexandros D, Cohen, Deirdre, Merad, Miriam, Wu, Kathy, Fazilov, Gabriela, Shelton, Gary, Marron, Thomas, Cameron, Amber, Yuan, Megan, Fitzgerald, Lisa
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Effects of TTI-621 (SIRPαFc) on CD47 and serum cytokines associated with phagocytosis in subjects with relapsed, refractory hematologic malignancies: Pharmacodynamic findings from a first-in-human clinical trial
Johnson, Lisa, Pillai, Raju K., King, Rebecca L., Ansell, Stephen Maxted, Chen, Robert W., Flinn, Ian, Maris, Michael B., Irwin, Meghan, Sievers, Eric L., Petrova, Penka S., Uger, Robert A.
Published in Journal of clinical oncology (01.03.2017)
Published in Journal of clinical oncology (01.03.2017)
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Journal Article
Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients
Su, Xi, Jin, Wenwen, Liu, Lizhi, Zhu, Zifei, Li, Cunyan
Published in Frontiers in immunology (04.12.2023)
Published in Frontiers in immunology (04.12.2023)
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Journal Article
Exploring NK cell dynamics and the CD47-SIRPα axis in colon cancer
Yilmaz, Latif, Oztuzcu, Serdar, Eronat, Omer, Ugur, Berna Kaya, Gumus, Mahmut, Guler, Semih, Tasdemir, Demet, Bozgeyik, Esra, Caska, Halil, Bozgeyik, Ibrahim
Published in Human immunology (01.03.2025)
Published in Human immunology (01.03.2025)
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Journal Article
Constructs having a SIRP-α domain or variant thereof
Year of Publication 02.05.2023
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Patent
Constructs having a SIRP-α domain or variant thereof
Wan, Hong, Pons, Jaume, Goodman, Corey, Deming, Laura, Sim, Bang Janet, Kauder, Steven Elliot, Kuo, Tracy Chia-Chien
Year of Publication 02.05.2023
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Year of Publication 02.05.2023
Patent
Treating pathological conditions by direct and indirect targeting of Sirpα - CD47 Interaction
SCHUMACHER, Antonius Nicolaas Maria, LEUSEN, Jeannette Henrica Wilhelmina, RAABEN, Matthijs, SCHEEREN, Ferenc Alexander, BRUMMELKAMP, Thijn Reinout, LOGTENBERG, Meike Emma Willemijn
Year of Publication 28.03.2024
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Year of Publication 28.03.2024
Patent
Anti SIRP-α antibodies and bi-specific macrophage enhancing antibodies
Year of Publication 22.09.2020
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Patent
Anti SIRP-α antibodies and bi-specific macrophage enhancing antibodies
Weiskopf, Kipp Andrew, Volkmer, Jens-Peter, Ring, Aaron Michael, Weissman, Irving L, Ring, Nan Guo
Year of Publication 22.09.2020
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Year of Publication 22.09.2020
Patent
Constructs having a SIRP-α domain or variant thereof
Wan, Hong, Pons, Jaume, Goodman, Corey, Deming, Laura, Sim, Bang Janet, Kauder, Steven Elliot, Kuo, Tracy Chia-Chien
Year of Publication 16.04.2019
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Year of Publication 16.04.2019
Patent
Constructs having a SIRP-α domain or variant thereof
Year of Publication 16.04.2019
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Patent