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Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations
Ikonomov, Ognian C., Sbrissa, Diego, Shisheva, Assia
Published in Toxicology and applied pharmacology (15.11.2019)
Published in Toxicology and applied pharmacology (15.11.2019)
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Journal Article
Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth
Govindarajan, Barani, Sbrissa, Diego, Pressprich, Mark, Kim, Seongho, Rishi, Arun K., Vaishampayan, Ulka, Cher, Michael L., Chinni, Sreenivasa R.
Published in Scientific reports (23.11.2023)
Published in Scientific reports (23.11.2023)
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Journal Article
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency
Compton, Lauren M, Ikonomov, Ognian C, Sbrissa, Diego, Garg, Puneet, Shisheva, Assia
Published in American Journal of Physiology: Cell Physiology (01.09.2016)
Published in American Journal of Physiology: Cell Physiology (01.09.2016)
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Journal Article
Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis
Ikonomov, Ognian C., Sbrissa, Diego, Venkatareddy, Madhusudan, Tisdale, Ellen, Garg, Puneet, Shisheva, Assia
Published in Biochimica et biophysica acta (01.05.2015)
Published in Biochimica et biophysica acta (01.05.2015)
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Journal Article
Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion
Ikonomov, Ognian C, Sbrissa, Diego, Shisheva, Assia
Published in American Journal of Physiology: Cell Physiology (01.08.2006)
Published in American Journal of Physiology: Cell Physiology (01.08.2006)
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Journal Article
cdc-Like/Dual-Specificity Tyrosine Phosphorylation–Regulated Kinases Inhibitor Leucettine L41 Induces mTOR-Dependent Autophagy: Implication for Alzheimer’s Disease
Fant, Xavier, Durieu, Emilie, Chicanne, Gaëtan, Payrastre, Bernard, Sbrissa, Diego, Shisheva, Assia, Limanton, Emmanuelle, Carreaux, François, Bazureau, Jean-Pierre, Meijer, Laurent
Published in Molecular pharmacology (01.03.2014)
Published in Molecular pharmacology (01.03.2014)
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Journal Article
The PIKfyve–ArPIKfyve–Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines
Ikonomov, Ognian C., Filios, Catherine, Sbrissa, Diego, Chen, Xuequn, Shisheva, Assia
Published in Biochemical and biophysical research communications (18.10.2013)
Published in Biochemical and biophysical research communications (18.10.2013)
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Journal Article
Role for a Novel Signaling Intermediate, Phosphatidylinositol 5-Phosphate, in Insulin-Regulated F-Actin Stress Fiber Breakdown and GLUT4 Translocation
Sbrissa, Diego, Ikonomov, Ognian C., Strakova, Jana, Shisheva, Assia
Published in Endocrinology (Philadelphia) (01.11.2004)
Published in Endocrinology (Philadelphia) (01.11.2004)
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Journal Article
Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin
Ikonomov, Ognian C., Fligger, Jason, Sbrissa, Diego, Dondapati, Rajeswari, Mlak, Krzysztof, Deeb, Robert, Shisheva, Assia
Published in The Journal of biological chemistry (06.02.2009)
Published in The Journal of biological chemistry (06.02.2009)
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Journal Article
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636
Sbrissa, Diego, Ikonomov, Ognian C, Filios, Catherine, Delvecchio, Khortnal, Shisheva, Assia
Published in American Journal of Physiology: Cell Physiology (15.08.2012)
Published in American Journal of Physiology: Cell Physiology (15.08.2012)
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Journal Article
Functional Dissection of Lipid and Protein Kinase Signals of PIKfyve Reveals the Role of PtdIns 3,5-P2 Production for Endomembrane Integrity
Ikonomov, Ognian C., Sbrissa, Diego, Mlak, Kristopher, Kanzaki, Makoto, Pessin, Jeffrey, Shisheva, Assia
Published in The Journal of biological chemistry (15.03.2002)
Published in The Journal of biological chemistry (15.03.2002)
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Journal Article
PIKfyve-ArPIKfyve-Sac3 Core Complex
Ikonomov, Ognian C., Sbrissa, Diego, Fenner, Homer, Shisheva, Assia
Published in The Journal of biological chemistry (18.12.2009)
Published in The Journal of biological chemistry (18.12.2009)
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Journal Article