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Orally Bioavailable Dopamine D1/D5 Receptor-Biased Agonists to Study the Role of β‑Arrestin in Treatment-Related Dyskinesia in Parkinson’s Disease
Rodríguez Sarmiento, Rosa María, Berchtold, Stefan, Manevski, Nenad, Lindemann, Lothar, Dey, Fabian, Clairfeuille, Thomas, Amendola, Davide, Vautrelle, Nicolas, Duveau, Venceslas, O′Connor, Eoin C.
Published in Journal of medicinal chemistry (10.07.2025)
Published in Journal of medicinal chemistry (10.07.2025)
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Journal Article
Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization
Benz, Joerg, Rufer, Arne C., Huber, Sylwia, Ehler, Andreas, Hug, Melanie, Topp, Andreas, Guba, Wolfgang, Hofmann, Eva Carolina, Jagasia, Ravi, Rodríguez Sarmiento, Rosa María
Published in Angewandte Chemie International Edition (01.03.2021)
Published in Angewandte Chemie International Edition (01.03.2021)
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Journal Article
Correction to Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O‑Methyltransferase Derived from a Fragment Screening Approach Targeting the S‑Adenosyl‑l‑methionine Pocket
Lerner, Christian, Jakob-Roetne, Roland, Buettelmann, Bernd, Ehler, Andreas, Rudolph, Markus G, Rodríguez Sarmiento, Rosa María
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
A new class of histamine H3 receptor antagonists derived from ligand based design
Roche, Olivier, Rodríguez Sarmiento, Rosa María
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O‑Methyltransferase Derived from a Fragment Screening Approach Targeting the S‑Adenosyl‑l‑methionine Pocket
Lerner, Christian, Jakob-Roetne, Roland, Buettelmann, Bernd, Ehler, Andreas, Rudolph, Markus, Rodríguez Sarmiento, Rosa María
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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Journal Article
Selective naphthalene H3 receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs
Rodríguez Sarmiento, Rosa María, Nettekoven, Matthias H., Taylor, Sven, Plancher, Jean-Marc, Richter, Hans, Roche, Olivier
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series
Pascale David Pierson, Christoph Ullmer, Sven Taylor, Tadakatsu Takahashi, Franz Schuler, Monique Schmitt, Rosa María Rodríguez Sarmiento, Olivier Roche, Hans Richter, Susanne Raab, Jean-Marc Plancher, Matthias Nettekoven, Toshito Nakagawa, Peter Mohr, Jörg Huwyler, Cornelia Hertel, Silvia Gatti-Mac Arthur, Christian Freichel, Ruby Wiegand
Published in Chimia (01.01.2009)
Published in Chimia (01.01.2009)
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Journal Article
Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
Rodríguez Sarmiento, Rosa María, Bissantz, Caterina, Bylund, Johan, Limberg, Anja, Neidhart, Werner, Jakob-Roetne, Roland, Wang, Lisha, Baumann, Karlheinz
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity
Pierson, Pascale David, Fettes, Alec, Freichel, Christian, Gatti-McArthur, Silvia, Hertel, Cornelia, Huwyler, Jörg, Mohr, Peter, Nakagawa, Toshito, Nettekoven, Matthias, Plancher, Jean-Marc, Raab, Susanne, Richter, Hans, Roche, Olivier, Rodríguez Sarmiento, Rosa María, Schmitt, Monique, Schuler, Franz, Takahashi, Tadakatsu, Taylor, Sven, Ullmer, Christoph, Wiegand, Ruby
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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Journal Article
The “five-star matrix” for patient-centric drug discovery and development in neuroscience
Pähler, Axel, O’Connor, Eoin C., Binch, Hayley, Dudal, Sherri, Gobbi, Luca C., Lübbers, Thomas, Olivares-Morales, Andrés, Rodríguez Sarmiento, Rosa María, Grether, Uwe, Stahl, Martin, Pagano, Gennaro, Stepan, Antonia F.
Published in Neuron (Cambridge, Mass.) (17.09.2025)
Published in Neuron (Cambridge, Mass.) (17.09.2025)
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Journal Article
Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization
Benz, Joerg, Rufer, Arne C., Huber, Sylwia, Ehler, Andreas, Hug, Melanie, Topp, Andreas, Guba, Wolfgang, Hofmann, Eva Carolina, Jagasia, Ravi, Rodríguez Sarmiento, Rosa María
Published in Angewandte Chemie (01.03.2021)
Published in Angewandte Chemie (01.03.2021)
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Journal Article
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Wlodek, Aleksandra, Kendrew, Steve G., Coates, Nigel J., Hold, Adam, Pogwizd, Joanna, Rudder, Steven, Sheehan, Lesley S., Higginbotham, Sarah J., Stanley-Smith, Anna E., Warneck, Tony, Nur-E-Alam, Mohammad, Radzom, Markus, Martin, Christine J., Overvoorde, Lois, Samborskyy, Markiyan, Alt, Silke, Heine, Daniel, Carter, Guy T., Graziani, Edmund I., Koehn, Frank E., McDonald, Leonard, Alanine, Alexander, Rodríguez Sarmiento, Rosa María, Chao, Suzan Keen, Ratni, Hasane, Steward, Lucinda, Norville, Isobel H., Sarkar-Tyson, Mitali, Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie, Gregory, Matthew A.
Published in Nature communications (31.10.2017)
Published in Nature communications (31.10.2017)
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Journal Article
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds
Trambauer, Johannes, Sarmiento, Rosa Maria Rodriguez, Garringer, Holly J., Salbaum, Katja, Pedro, Liliana D., Crusius, Dennis, Vidal, Ruben, Ghetti, Bernardino, Paquet, Dominik, Baumann, Karlheinz, Lindemann, Lothar, Steiner, Harald
Published in Alzheimer's research & therapy (19.02.2025)
Published in Alzheimer's research & therapy (19.02.2025)
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Journal Article
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease
Ratni, Hasane, Alker, Andre, Bartels, Bjoern, Bissantz, Caterina, Chen, Weichun, Gerlach, Irene, Limberg, Anja, Lu, Mingqiu, Neidhart, Werner, Pichereau, Solen, Reutlinger, Michael, Rodriguez-Sarmiento, Rosa-Maria, Jakob-Roetne, Roland, Schmitt, Georg, Zhang, Eric, Baumann, Karlheinz
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds
Trambauer, Johannes, Sarmiento, Rosa Maria Rodriguez, Garringer, Holly J., Salbaum, Katja, Pedro, Liliana D., Crusius, Dennis, Vidal, Ruben, Ghetti, Bernardino, Paquet, Dominik, Baumann, Karlheinz, Lindemann, Lothar, Steiner, Harald
Published in Alzheimer's research & therapy (15.04.2025)
Published in Alzheimer's research & therapy (15.04.2025)
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Journal Article
Selective naphthalene H(3) receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs
Rodríguez Sarmiento, Rosa María, Nettekoven, Matthias H, Taylor, Sven, Plancher, Jean-Marc, Richter, Hans, Roche, Olivier
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
A new class of histamine H 3 receptor antagonists derived from ligand based design
Roche, Olivier, Rodríguez Sarmiento, Rosa María
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Get full text
Journal Article