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Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression
Li, Yangbing, Yang, Jiuling, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Liu, Liu, Yang, Chao-Yie, Wang, Mi, Han, Xin, Wang, Shaomeng
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Journal Article
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Ziazadeh, Danya N, Xu, Fuming, Hu, Jiantao, Xiang, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer
Bai, Longchuan, Zhou, Bing, Yang, Chao-Yie, Ji, Jiao, McEachern, Donna, Przybranowski, Sally, Jiang, Hui, Hu, Jiantao, Xu, Fuming, Zhao, Yujun, Liu, Liu, Fernandez-Salas, Ester, Xu, Jing, Dou, Yali, Wen, Bo, Sun, Duxin, Meagher, Jennifer, Stuckey, Jeanne, Hayes, Daniel F., Li, Shunqiang, Ellis, Matthew J., Wang, Shaomeng
Published in Cancer research (Chicago, Ill.) (01.05.2017)
Published in Cancer research (Chicago, Ill.) (01.05.2017)
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Journal Article
Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma
Zasłona, Zbigniew, Przybranowski, Sally, Wilke, Carol, van Rooijen, Nico, Teitz-Tennenbaum, Seagal, Osterholzer, John J, Wilkinson, John E, Moore, Bethany B, Peters-Golden, Marc
Published in The Journal of immunology (1950) (15.10.2014)
Published in The Journal of immunology (1950) (15.10.2014)
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Journal Article
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
Bourdonnay, Emilie, Zasłona, Zbigniew, Penke, Loka Raghu Kumar, Speth, Jennifer M., Schneider, Daniel J., Przybranowski, Sally, Swanson, Joel A., Mancuso, Peter, Freeman, Christine M., Curtis, Jeffrey L., Peters-Golden, Marc
Published in The Journal of experimental medicine (04.05.2015)
Published in The Journal of experimental medicine (04.05.2015)
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Journal Article
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
Barrett, Stephen D., Bridges, Alexander J., Dudley, David T., Saltiel, Alan R., Fergus, James H., Flamme, Cathlin M., Delaney, Amy M., Kaufman, Michael, LePage, Sophie, Leopold, Wilbur R., Przybranowski, Sally A., Sebolt-Leopold, Judith, Van Becelaere, Keri, Doherty, Annette M., Kennedy, Robert M., Marston, Dan, Howard, W. Allen, Smith, Yvonne, Warmus, Joseph S., Tecle, Haile
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Journal Article
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Lauchle, Jennifer O., Kim, Doris, Le, Doan T., Akagi, Keiko, Crone, Michael, Krisman, Kimberly, Warner, Kegan, Bonifas, Jeannette M., Li, Qing, Coakley, Kristen M., Diaz-Flores, Ernesto, Gorman, Matthew, Przybranowski, Sally, Tran, Mary, Kogan, Scott C., Roose, Jeroen P., Copeland, Neal G., Jenkins, Nancy A., Parada, Luis, Wolff, Linda, Sebolt-Leopold, Judith, Shannon, Kevin
Published in Nature (London) (17.09.2009)
Published in Nature (London) (17.09.2009)
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Journal Article
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
Sebolt-Leopold, Judith S., Dudley, David T., Herrera, Roman, Becelaere, Keri Van, Wiland, Amy, Gowan, Richard C., Tecle, Haile, Barrett, Stephen D., Bridges, Alexander, Przybranowski, Sally, Leopold, W.R., Saltiel, Alan R.
Published in Nature medicine (01.07.1999)
Published in Nature medicine (01.07.1999)
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Journal Article
A Role for K-ras in Conferring Resistance to the MEK Inhibitor, CI-1040
Wangab, Yuli, Van Becelaere, Keri, Jiang, Ping, Przybranowski, Sally, Omer, Charles, Sebolt-Leopold, Judith
Published in Neoplasia (New York, N.Y.) (01.04.2005)
Published in Neoplasia (New York, N.Y.) (01.04.2005)
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Journal Article
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression
Zhou, Bing, Hu, Jiantao, Xu, Fuming, Chen, Zhuo, Bai, Longchuan, Fernandez-Salas, Ester, Lin, Mei, Liu, Liu, Yang, Chao-Yie, Zhao, Yujun, McEachern, Donna, Przybranowski, Sally, Wen, Bo, Sun, Duxin, Wang, Shaomeng
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
Aguilar, Angelo, Lu, Jianfeng, Liu, Liu, Du, Ding, Bernard, Denzil, McEachern, Donna, Przybranowski, Sally, Li, Xiaoqin, Luo, Ruijuan, Wen, Bo, Sun, Duxin, Wang, Hengbang, Wen, Jianfeng, Wang, Guangfeng, Zhai, Yifan, Guo, Ming, Yang, Dajun, Wang, Shaomeng
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Discovery of M‑808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity
Xu, Shilin, Aguilar, Angelo, Huang, Liyue, Xu, Tianfeng, Zheng, Ke, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Zawacki, Kaitlin, Liu, Zhaomin, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Wang, Shaomeng
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Journal Article
Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction
Xu, Shilin, Aguilar, Angelo, Xu, Tianfeng, Zheng, Ke, Huang, Liyue, Stuckey, Jeanne, Chinnaswamy, Krishnapriya, Bernard, Denzil, Fernández‐Salas, Ester, Liu, Liu, Wang, Mi, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Wang, Shaomeng
Published in Angewandte Chemie (International ed.) (05.02.2018)
Published in Angewandte Chemie (International ed.) (05.02.2018)
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Journal Article
Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy
Deng, Jing, Paulus, Aneel, Fang, Douglas D., Manna, Alak, Wang, Guangfeng, Wang, Hengbang, Zhu, Saijie, Chen, Jianyong, Min, Ping, Yin, Yan, Dutta, Navnita, Halder, Nabanita, Ciccio, Gina, Copland, John A., Miller, James, Han, Bing, Bai, Longchuan, Liu, Liu, Wang, Mi, McEachern, Donna, Przybranowski, Sally, Yang, Chao-Yie, Stuckey, Jeanne A., Wu, Depei, Li, Caixia, Ryan, Jeremy, Letai, Anthony, Ailawadhi, Sikander, Yang, Dajun, Wang, Shaomeng, Chanan-Khan, Asher, Zhai, Yifan
Published in Clinical cancer research (15.12.2022)
Published in Clinical cancer research (15.12.2022)
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Journal Article
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor
Zhao, Yujun, Zhou, Bing, Bai, Longchuan, Liu, Liu, Yang, Chao-Yie, Meagher, Jennifer L, Stuckey, Jeanne A, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Ran, Xu, Aguilar, Angelo, Hu, Yang, Kampf, Jeff W, Li, Xiaoqin, Zhao, Ting, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Journal Article
Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression
Chen, Jianyong, Zhou, Yunlong, Dong, Xuyuan, Liu, Liu, Bai, Longchuan, McEachern, Donna, Przybranowski, Sally, Yang, Chao-Yie, Stuckey, Jeanne, Li, Xiaoqin, Wen, Bo, Zhao, Ting, Sun, Siwei, Sun, Duxin, Jiao, Lingling, Jing, Yu, Guo, Ming, Yang, Dajun, Wang, Shaomeng
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Journal Article
Abstract 5074: Therapeutic targeting of bromodomain and extra-terminal proteins degradation in triple-negative breast cancer
Bai, Longchuan, Zhou, Bing, Yang, Chao-Yie, Ji, Jiao, McEachern, Donna, Przybranowski, Sally, Wang, Shaomeng
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression
Li, Yangbing, Yang, Jiuling, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Liu, Liu, Yang, Chao-Yie, Wang, Mi, Han, Xin, Wang, Shaomeng
Published in Journal of medicinal chemistry (10.12.2018)
Published in Journal of medicinal chemistry (10.12.2018)
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Journal Article
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction
Xu, Shilin, Aguilar, Angelo, Xu, Tianfeng, Zheng, Ke, Huang, Liyue, Stuckey, Jeanne, Chinnaswamy, Krishnapriya, Bernard, Denzil, Fernández‐Salas, Ester, Liu, Liu, Wang, Mi, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Wang, Shaomeng
Published in Angewandte Chemie (International ed.) (28.12.2017)
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Published in Angewandte Chemie (International ed.) (28.12.2017)
Journal Article