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Semysinthetic biflavonoid Morelloflavone-7,4′,7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin
de Souza, Aline Aparecida, de Andrade, Débora Martins, Siqueira, Fábio da Silva, Di Iorio, Juliana Fortes, Veloso, Marcia Paranho, Coelho, Camila de Morais, Viegas Junior, Claudio, Gontijo, Vanessa Silva, dos Santos, Marcelo Henrique, Meneghetti, Maria Cecília Zorél, Nader, Helena Bonciani, Tersariol, Ivarne Luis dos Santos, Juliano, Luiz, Juliano, Maria Aparecida, Judice, Wagner Alves de Souza
Published in Biochimica et biophysica acta. General subjects (01.12.2021)
Published in Biochimica et biophysica acta. General subjects (01.12.2021)
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Journal Article
Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol
Stein, Evan A, Mellis, Scott, Yancopoulos, George D, Stahl, Neil, Logan, Douglas, Smith, William B, Lisbon, Eleanor, Gutierrez, Maria, Webb, Cheryle, Wu, Richard, Du, Yunling, Kranz, Therese, Gasparino, Evelyn, Swergold, Gary D
Published in The New England journal of medicine (22.03.2012)
Published in The New England journal of medicine (22.03.2012)
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Journal Article
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
Fitzgerald, Kevin, Frank-Kamenetsky, Maria, Shulga-Morskaya, Svetlana, Liebow, Abigail, Bettencourt, Brian R, Sutherland, Jessica E, Hutabarat, Renta M, Clausen, Valerie A, Karsten, Verena, Cehelsky, Jeffrey, Nochur, Saraswathy V, Kotelianski, Victor, Horton, Jay, Mant, Timothy, Chiesa, Joseph, Ritter, James, Munisamy, Malathy, Vaishnaw, Akshay K, Gollob, Jared A, Simon, Amy
Published in The Lancet (British edition) (04.01.2014)
Published in The Lancet (British edition) (04.01.2014)
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Journal Article
Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial
Bjermo, Helena, Iggman, David, Kullberg, Joel, Dahlman, Ingrid, Johansson, Lars, Persson, Lena, Berglund, Johan, Pulkki, Kari, Basu, Samar, Uusitupa, Matti, Rudling, Mats, Arner, Peter, Cederholm, Tommy, Ahlström, Håkan, Risérus, Ulf
Published in The American journal of clinical nutrition (01.05.2012)
Published in The American journal of clinical nutrition (01.05.2012)
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Journal Article
Results of Bococizumab, A Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, from a Randomized, Placebo-Controlled, Dose-Ranging Study in Statin-Treated Subjects With Hypercholesterolemia
Ballantyne, Christie M., Neutel, Joel, Cropp, Anne, Duggan, William, Wang, Ellen Q., Plowchalk, David, Sweeney, Kevin, Kaila, Nitin, Vincent, John, Bays, Harold
Published in The American journal of cardiology (01.05.2015)
Published in The American journal of cardiology (01.05.2015)
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Journal Article
Anti-PCSK9 Antibody Effectively Lowers Cholesterol in Patients With Statin Intolerance: The GAUSS-2 Randomized, Placebo-Controlled Phase 3 Clinical Trial of Evolocumab
STROES, Erik, COLQUHOUN, David, XUE, Allen, SCOTT, Rob, WASSERMAN, Scott M, ROCCO, Michael, SULLIVAN, David, CIVEIRA, Fernando, ROSENSON, Robert S, WATTS, Gerald F, BRUCKERT, Eric, CHO, Leslie, DENT, Ricardo, KNUSEL, Beat
Published in Journal of the American College of Cardiology (17.06.2014)
Published in Journal of the American College of Cardiology (17.06.2014)
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Journal Article
Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins
DIAS, Clapton S, SHAYWITZ, Adam J, GIBBS, John P, RETTER, Marc W, COOKE, Blaire P, UY, Stephen T, MATSON, Mark, STEIN, Evan A, WASSERMAN, Scott M, SMITH, Brian P, BING GAO, STOLMAN, Dina S, CRISPINO, Caroline P, SMIRNAKIS, Karen V, EMERY, Maurice G, COLBERT, Alexander
Published in Journal of the American College of Cardiology (06.11.2012)
Published in Journal of the American College of Cardiology (06.11.2012)
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Journal Article
Anti-PCSK9 Monotherapy for Hypercholesterolemia: The MENDEL-2 Randomized, Controlled Phase III Clinical Trial of Evolocumab
KOREN, Michael J, LUNDQVIST, Pernille, BOLOGNESE, Michael, NEUTEL, Joel M, MONSALVO, Maria Laura, JINGYUAN YANG, KIM, Jae B, SCOTT, Rob, WASSERMAN, Scott M, BAYS, Harold
Published in Journal of the American College of Cardiology (17.06.2014)
Published in Journal of the American College of Cardiology (17.06.2014)
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Journal Article
Molecular Lipids Identify Cardiovascular Risk and Are Efficiently Lowered by Simvastatin and PCSK9 Deficiency
Tarasov, Kirill, Ekroos, Kim, Suoniemi, Matti, Kauhanen, Dimple, Sylvänne, Tuulia, Hurme, Reini, Gouni-Berthold, Ioanna, Berthold, Heiner K., Kleber, Marcus E., Laaksonen, Reijo, März, Winfried
Published in The journal of clinical endocrinology and metabolism (01.01.2014)
Published in The journal of clinical endocrinology and metabolism (01.01.2014)
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Journal Article
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody
Hopkins, Paul N., Defesche, Joep, Fouchier, Sigrid W., Bruckert, Eric, Luc, Gérald, Cariou, Bertrand, Sjouke, Barbara, Leren, Trond P., Harada-Shiba, Mariko, Mabuchi, Hiroshi, Rabès, Jean-Pierre, Carrié, Alain, van Heyningen, Charles, Carreau, Valérie, Farnier, Michel, Teoh, Yee P., Bourbon, Mafalda, Kawashiri, Masa-aki, Nohara, Atsushi, Soran, Handrean, Marais, A. David, Tada, Hayato, Abifadel, Marianne, Boileau, Catherine, Chanu, Bernard, Katsuda, Shoji, Kishimoto, Ichiro, Lambert, Gilles, Makino, Hisashi, Miyamoto, Yoshihiro, Pichelin, Matthieu, Yagi, Kunimasa, Yamagishi, Masakazu, Zair, Yassine, Mellis, Scott, Yancopoulos, George D., Stahl, Neil, Mendoza, Johanna, Du, Yunling, Hamon, Sara, Krempf, Michel, Swergold, Gary D.
Published in Circulation. Cardiovascular genetics (01.12.2015)
Published in Circulation. Cardiovascular genetics (01.12.2015)
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Journal Article
Inter-relationships between proprotein convertase subtilisin/kexin type 9, apolipoprotein C-III and plasma apolipoprotein B-48 transport in obese subjects: a stable isotope study in the postprandial state
Chan, Dick C., Wong, Annette T. Y., Pang, Jing, Barrett, P. Hugh R., Watts, Gerald F.
Published in Clinical science (1979) (01.03.2015)
Published in Clinical science (1979) (01.03.2015)
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Journal Article
Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation
Kosenko, Tanja, Golder, Mia, Leblond, Geoffrey, Weng, Willy, Lagace, Thomas A.
Published in The Journal of biological chemistry (22.03.2013)
Published in The Journal of biological chemistry (22.03.2013)
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Journal Article
Rationale and design of the Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk trial
Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony, Honarpour, Narimon, Wang, Huei, Liu, Thomas, Wasserman, Scott M., Scott, Robert, Sever, Peter S., Pedersen, Terje R.
Published in The American heart journal (01.03.2016)
Published in The American heart journal (01.03.2016)
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Journal Article
Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy
Bertolini, Stefano, Pisciotta, Livia, Rabacchi, Claudio, Cefalù, Angelo B., Noto, Davide, Fasano, Tommaso, Signori, Alessio, Fresa, Raffaele, Averna, Maurizio, Calandra, Sebastiano
Published in Atherosclerosis (01.04.2013)
Published in Atherosclerosis (01.04.2013)
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Journal Article
A Randomized Study of the Relative Pharmacokinetics, Pharmacodynamics, and Safety of Alirocumab, a Fully Human Monoclonal Antibody to PCSK9, After Single Subcutaneous Administration at Three Different Injection Sites in Healthy Subjects
Lunven, Catherine, Paehler, Tobias, Poitiers, Franck, Brunet, Aurélie, Rey, Jacques, Hanotin, Corinne, Sasiela, William J.
Published in Cardiovascular therapeutics (01.12.2014)
Published in Cardiovascular therapeutics (01.12.2014)
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Journal Article
Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study
Rosqvist, Fredrik, Smedman, Annika, Lindmark-Månsson, Helena, Paulsson, Marie, Petrus, Paul, Straniero, Sara, Rudling, Mats, Dahlman, Ingrid, Risåérus, Ulf
Published in The American journal of clinical nutrition (01.07.2015)
Published in The American journal of clinical nutrition (01.07.2015)
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Journal Article
Intestinal Lipid Handling: Evidence and Implication of Insulin Signaling Abnormalities in Human Obese Subjects
Veilleux, Alain, Grenier, Émilie, Marceau, Picard, Carpentier, André C., Richard, Denis, Levy, Emile
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2014)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2014)
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Journal Article
Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization
Evdokimov, Konstantin, Biswas, Siladitta, Adrian, Monica, Weber, Jochen, Schledzewski, Kai, Winkler, Manuel, Goerdt, Sergij, Géraud, Cyrill
Published in Biochemical and biophysical research communications (26.04.2013)
Published in Biochemical and biophysical research communications (26.04.2013)
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Journal Article