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Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL
Nagel, Daniel, Spranger, Stefani, Vincendeau, Michelle, Grau, Michael, Raffegerst, Silke, Kloo, Bernhard, Hlahla, Daniela, Neuenschwander, Martin, Peter von Kries, Jens, Hadian, Kamyar, Dörken, Bernd, Lenz, Peter, Lenz, Georg, Schendel, Dolores J., Krappmann, Daniel
Published in Cancer cell (11.12.2012)
Published in Cancer cell (11.12.2012)
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Journal Article
Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo
Grosskopf, Stefanie, Eckert, Chris, Arkona, Christoph, Radetzki, Silke, Böhm, Kerstin, Heinemann, Udo, Wolber, Gerhard, von Kries, Jens-Peter, Birchmeier, Walter, Rademann, Jörg
Published in ChemMedChem (01.05.2015)
Published in ChemMedChem (01.05.2015)
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Journal Article
Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition
von Kleist, Lisa, Stahlschmidt, Wiebke, Bulut, Haydar, Gromova, Kira, Puchkov, Dmytro, Robertson, Mark J., MacGregor, Kylie A., Tomlin, Nikolay, Pechstein, Arndt, Chau, Ngoc, Chircop, Megan, Sakoff, Jennette, von Kries, Jens Peter, Saenger, Wolfram, Kräusslich, Hans-Georg, Shupliakov, Oleg, Robinson, Phillip J., McCluskey, Adam, Haucke, Volker
Published in Cell (05.08.2011)
Published in Cell (05.08.2011)
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Journal Article
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Ullrich, Florian, Blin, Sandy, Lazarow, Katina, Daubitz, Tony, von Kries, Jens Peter, Jentsch, Thomas J
Published in eLife (18.07.2019)
Published in eLife (18.07.2019)
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Journal Article
7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase
Brenner, Marian, Zink, Christoph, Witzinger, Linda, Keller, Angelika, Hadamek, Kerstin, Bothe, Sebastian, Neuenschwander, Martin, Villmann, Carmen, von Kries, Jens Peter, Schindelin, Hermann, Jeanclos, Elisabeth, Gohla, Antje
Published in eLife (10.06.2024)
Published in eLife (10.06.2024)
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Journal Article
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
Hellmuth, Klaus, Grosskopf, Stefanie, Lum, Ching Tung, Würtele, Martin, Röder, Nadine, von Kries, Jens Peter, Rosario, Marta, Rademann, Jörg, Birchmeier, Walter
Published in Proceedings of the National Academy of Sciences - PNAS (20.05.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (20.05.2008)
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Journal Article
Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling
Liss, Martin, Radke, Michael H., Eckhard, Jamina, Neuenschwander, Martin, Dauksaite, Vita, von Kries, Jens-Peter, Gotthardt, Michael
Published in PloS one (11.06.2018)
Published in PloS one (11.06.2018)
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Journal Article
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
Aguirre, Tim, Dornan, Gillian L, Hostachy, Sarah, Neuenschwander, Martin, Seyffarth, Carola, Haucke, Volker, Schütz, Anja, von Kries, Jens Peter, Fiedler, Dorothea
Published in eLife (16.10.2023)
Published in eLife (16.10.2023)
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Journal Article
Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
Klein, Wolfgang, Rutz, Claudia, Eckhard, Jamina, Provinciael, Becky, Specker, Edgar, Neuenschwander, Martin, Kleinau, Gunnar, Scheerer, Patrick, von Kries, Jens-Peter, Nazaré, Marc, Vermeire, Kurt, Schülein, Ralf
Published in PloS one (13.12.2018)
Published in PloS one (13.12.2018)
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Journal Article
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis
Due, Anne V, Kuper, Jochen, Geerlof, Arie, Kries, Jens Peter von, Wilmanns, Matthias
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
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Journal Article
Morphological profiling data resource enables prediction of chemical compound properties
Wolff, Christopher, Neuenschwander, Martin, Beese, Carsten Jörn, Sitani, Divya, Ramos, Maria C., Srovnalova, Alzbeta, Varela, María José, Polishchuk, Pavel, Skopelitou, Katholiki E., Škuta, Ctibor, Stechmann, Bahne, Brea, José, Clausen, Mads Hartvig, Dzubak, Petr, Fernández-Godino, Rosario, Genilloud, Olga, Hajduch, Marian, Loza, María Isabel, Lehmann, Martin, Peter von Kries, Jens, Sun, Han, Schmied, Christopher
Published in iScience (16.05.2025)
Published in iScience (16.05.2025)
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Journal Article
Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation
Renikunta, Harsha V., Lazarow, Katina, Gong, Yiqi, Shukla, Praphulla Chandra, Nageswaran, Vanasa, Giral, Hector, Kratzer, Adelheid, Opitz, Lennart, Engel, Felix B., Haghikia, Arash, Costantino, Sarah, Paneni, Francesco, von Kries, Jens Peter, Streckfuss-Bömeke, Katrin, Landmesser, Ulf, Jakob, Philipp
Published in iScience (19.05.2023)
Published in iScience (19.05.2023)
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Journal Article
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
Eswaran, Jeyanthy, von Kries, Jens Peter, Marsden, Brian, Longman, Emma, Debreczeni, Judit É., Ugochukwu, Emilie, Turnbull, Andrew, Lee, Wen Hwa, Knapp, Stefan, Barr, Alastair J.
Published in Biochemical journal (01.05.2006)
Published in Biochemical journal (01.05.2006)
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Journal Article
A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
Waaler, Jo, Machon, Ondrej, Tumova, Lucie, Dinh, Huyen, Korinek, Vladimir, Wilson, Steven Ray, Paulsen, Jan Erik, Pedersen, Nina Marie, Eide, Tor J., Machonova, Olga, Gradl, Dietmar, Voronkov, Andrey, von Kries, Jens Peter, Krauss, Stefan
Published in Cancer research (Chicago, Ill.) (01.06.2012)
Published in Cancer research (Chicago, Ill.) (01.06.2012)
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Journal Article
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
Mohd, Saif, Oder, Andreas, Specker, Edgar, Neuenschwander, Martin, Von Kries, Jens Peter, Daumke, Oliver
Published in PloS one (29.07.2024)
Published in PloS one (29.07.2024)
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Journal Article
Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells
Yusenko, Maria V., Trentmann, Amke, Andersson, Mattias K., Ghani, Luca Abdel, Jakobs, Anke, Arteaga Paz, Mari-Francis, Mikesch, Jan-Henrik, Peter von Kries, Jens, Stenman, Göran, Klempnauer, Karl-Heinz
Published in Cancer letters (01.06.2020)
Published in Cancer letters (01.06.2020)
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Journal Article
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis
Horatscheck, André, Krauß, Michael, Bulut, Haydar, Chambon, Valerie, Zadah, Massilullah Shafaq, Dransart, Estelle, Peloza, Kimberly, Santos, Karine F., Robertson, Mark J., Prichard, Kate, Miksche, Sandra, Radetzki, Silke, von Kries, Jens-Peter, Wahl, Markus C., McCluskey, Adam, Johannes, Ludger, Haucke, Volker, Nazaré, Marc
Published in Structure (London) (01.05.2025)
Published in Structure (London) (01.05.2025)
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Journal Article
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
Juneja, Manisha, Kobelt, Dennis, Walther, Wolfgang, Voss, Cynthia, Smith, Janice, Specker, Edgar, Neuenschwander, Martin, Gohlke, Björn-Oliver, Dahlmann, Mathias, Radetzki, Silke, Preissner, Robert, von Kries, Jens Peter, Schlag, Peter Michael, Stein, Ulrike
Published in PLoS biology (01.06.2017)
Published in PLoS biology (01.06.2017)
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Journal Article