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Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
Ruella, Marco, Barrett, David M., Kenderian, Saad S., Shestova, Olga, Hofmann, Ted J., Perazzelli, Jessica, Klichinsky, Michael, Aikawa, Vania, Nazimuddin, Farzana, Kozlowski, Miroslaw, Scholler, John, Lacey, Simon F., Melenhorst, Jan J., Morrissette, Jennifer J.D., Christian, David A., Hunter, Christopher A., Kalos, Michael, Porter, David L., June, Carl H., Grupp, Stephan A., Gill, Saar
Published in The Journal of clinical investigation (03.10.2016)
Published in The Journal of clinical investigation (03.10.2016)
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Journal Article
Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells
Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco
Published in Nature medicine (01.05.2021)
Published in Nature medicine (01.05.2021)
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Journal Article
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Sotillo, Elena, Barrett, David M., Black, Kathryn L., Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R., Martinez, Nicole M., Harrington, Colleen T., Chung, Elaine Y., Perazzelli, Jessica, Hofmann, Ted J., Maude, Shannon L., Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F., Melenhorst, Jan J., Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W., Maris, John M., Grupp, Stephan A., Thomas-Tikhonenko, Andrei
Published in Cancer discovery (01.12.2015)
Published in Cancer discovery (01.12.2015)
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Journal Article
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19
Diorio, Caroline, Shraim, Rawan, Myers, Regina, Behrens, Edward M., Canna, Scott, Bassiri, Hamid, Aplenc, Richard, Burudpakdee, Chakkapong, Chen, Fang, DiNofia, Amanda M., Gill, Saar, Gonzalez, Vanessa, Lambert, Michele P., Leahy, Allison Barz, Levine, Bruce L., Lindell, Robert B., Maude, Shannon L., Melenhorst, J. Joseph, Newman, Haley, Perazzelli, Jessica, Seif, Alix E., Lacey, Simon F., June, Carl H., Barrett, David M., Grupp, Stephan A., Teachey, David T.
Published in Clinical cancer research (01.09.2022)
Published in Clinical cancer research (01.09.2022)
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Journal Article
Abstract 2622: T cell content of lymphatic fluid in pediatric patients is biased towards naïve and early memory cells: Implications for immunotherapy
Barrett, David M., Storm, Julie, Perazzelli, Jessica, Dori, Yoav
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum
Bagashev, Asen, Sotillo, Elena, Tang, Chih-Hang Anthony, Black, Kathryn L., Perazzelli, Jessica, Seeholzer, Steven H., Argon, Yair, Barrett, David M., Grupp, Stephan A., Hu, Chih-Chi Andrew, Thomas-Tikhonenko, Andrei
Published in Molecular and cellular biology (01.11.2018)
Published in Molecular and cellular biology (01.11.2018)
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Journal Article
In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing
Hopkins, Caitlin R., DiNofia, Amanda M., Maude, Shannon L., Chen, Gregory M., Boateng-Antwi, Kwame Attah M., Perazzelli, Jessica, Mendez Corea, Andres F., Shestov, Alexander, Gohil, Mercy, Li, Yimei, Hwang, Wei-Ting, Valentić, Bakir, Christensen, Shannon, Jadlowsky, Julie, Myers, Regina M., Diorio, Caroline, Davis, Megan M., Colligon, Theresa, Plesa, Gabriela, Siegel, Don L., Levine, Bruce, June, Carl H., O'Connor, Roddy S., Grupp, Stephan A., Fraietta, Joseph A.
Published in Blood (05.11.2024)
Published in Blood (05.11.2024)
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Journal Article
A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor–positive cells
Ruella, Marco, Barrett, David M., Shestova, Olga, Perazzelli, Jessica, Posey, Avery D., Hong, Seok Jae, Kozlowski, Miroslaw, Lacey, Simon F., Melenhorst, J. Joseph, June, Carl H., Gill, Saar I.
Published in Blood (13.02.2020)
Published in Blood (13.02.2020)
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Journal Article
Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor
Machietto, Rene, Giacobbe, Nicholas, Perazzelli, Jessica, Hofmann, Ted J., Barz Leahy, Allison, Grupp, Stephan A., Wang, Yongping, Kadauke, Stephan
Published in Journal of visualized experiments (18.08.2023)
Published in Journal of visualized experiments (18.08.2023)
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Journal Article
Correction for Bagashev et al., "CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum"
Bagashev, Asen, Sotillo, Elena, Tang, Chih-Hang Anthony, Black, Kathryn L., Perazzelli, Jessica, Seeholzer, Steven H., Argon, Yair, Barrett, David M., Grupp, Stephan A., Hu, Chih-Chi Andrew, Thomas-Tikhonenko, Andrei
Published in Molecular and cellular biology (01.09.2022)
Published in Molecular and cellular biology (01.09.2022)
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Journal Article
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell Associated Neurotoxicity Syndrome in B-Cell ALL Patients Receiving CART19
Diorio, Caroline, Shraim, Rawan, Myers, Regina, Behrens, Edward M, Canna, Scott, Bassiri, Hamid, Aplenc, Richard, Burudpakdee, Chakkapong, Chen, Fang, DiNofia, Amanda M., Gill, Saar, Gonzalez, Vanessa, Lambert, Michele P., Leahy, Allison Barz, Levine, Bruce L, Lindell, Robert B., Maude, Shannon L, Melenhorst, J. Joseph, Newman, Haley, Perazzelli, Jessica, Seif, Alix E., Lacey, Simon F., June, Carl H., Barrett, David M., Grupp, Stephan A., Teachey, David T.
Published in Clinical cancer research (01.09.2022)
Published in Clinical cancer research (01.09.2022)
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Journal Article
A Cellular Antidote to Specifically Deplete Anti-CD19 Chimeric Antigen Receptor (CAR19) Positive Cells
Ruella, Marco, Barrett, David M., Shestova, Olga, Perazzelli, Jessica, Posey, Avery D., Kozlowski, Miroslaw, Lacey, Simon F, Melenhorst, J. Joseph, June, Carl H, Gill, Saar I.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Antigen-independent activation enhances the efficacy of 41BB co-stimulated CD22 CAR T cells
Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Maggie Lu, Xueqing, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco
Published in Nature medicine (22.04.2021)
Published in Nature medicine (22.04.2021)
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Journal Article
Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy
Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Shyu, Amy, Highfill, Steven, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xeuqing Maggie, Christian, David A, Perazzelli, Jessica, Lacey, Simon F, Roy, Nathan, Burkhardt, Janis K, Colomb, Florent, Abdel-Mohsen, Mohamed, Young, Regina M, Brogdon, Jennifer, Grupp, Stephan, June, Carl H, Maude, Shannon L., Gill, Saar I., Ruella, Marco
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Clinical Efficacy of Anti-CD22 Chimeric Antigen Receptor T Cells for B-Cell Acute Lymphoblastic Leukemia Is Correlated with the Length of the Scfv Linker and Can be Predicted Using Xenograft Models
Ruella, Marco, Maude, Shannon L, Engels, Boris, Barrett, David M., Frey, Noelle, Marcucci, Katherine T, Shestova, Olga, Singh, Nathan, Perazzelli, Jessica, Christian, David A, Haagen, Dana, Lacey, Simon F, Melenhorst, J. Joseph, Brogdon, Jennifer, Young, Regina M, Porter, David L, June, Carl H, Grupp, Stephan A, Gill, Saar I.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
Ruella, Marco, Barrett, David M, Kenderian, Saad S, Shestova, Olga, Hofmann, Ted J, Perazzelli, Jessica, Klichinsky, Michael, Aikawa, Vania, Nazimuddin, Farzana, Kozlowski, Miroslaw, Scholler, John, Lacey, Simon F, Melenhorst, Jan J, Morrissette, Jennifer J.D, Christian, David A, Hunter, Christopher A, Kalos, Michael, Porter, David L, June, Carl H, Grupp, Stephan A, Gill, Saar
Published in The Journal of clinical investigation (01.10.2016)
Published in The Journal of clinical investigation (01.10.2016)
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Journal Article
Combination of Anti-CD123 and Anti-CD19 Chimeric Antigen Receptor T Cells for the Treatment and Prevention of Antigen-Loss Relapses Occurring after CD19-Targeted Immunotherapies
Ruella, Marco, Barrett, David M., Kenderian, Saad S, Shestova, Olga, Hofmann, Ted J., Scholler, John, Lacey, Simon F., Melenhorst, J. Joseph, Nazimuddin, Farzana, Perazzelli, Jessica, Christian, David A, Hunter, Christopher A, Porter, David L, June, Carl H., Grupp, Stephan A., Gill, Saar I
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells
Ruella, Marco, Barrett, David M, Kenderian, Saad S, Shestova, Olga, Hofmann, Ted J, Scholler, John, Lacey, Simon F, Melenhorst, Jan J, Nazimuddin, Farzana, Perazzelli, Jessica, Christian, David A, Hunter, Christopher A, Porter, David L, June, Carl H, Grupp, Stephan A, Gill, Saar
Published in Journal for immunotherapy of cancer (04.11.2015)
Published in Journal for immunotherapy of cancer (04.11.2015)
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Journal Article
Immunogenomic profiling of circulating T cells in pediatric cancer patients during standard-of-care
Nabbi, Arash, Jiang, Yiyue, Osvaldo Espin Garcia, Mohanraj, Suluxan, Pedersen, Stephanie, Regala, Johanna, Vernau, Lauren, Perazzelli, Jessica, Barrett, David M, Pugh, Trevor J
Published in bioRxiv (13.01.2025)
Published in bioRxiv (13.01.2025)
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Paper
Antitrust enforcement and intellectual property rights
Collins, John F, Perazzelli, Jessica L
Published in The IP Litigator : Devoted to Intellectual Property Litigation and Enforcement (01.09.2007)
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Published in The IP Litigator : Devoted to Intellectual Property Litigation and Enforcement (01.09.2007)
Journal Article
Trade Publication Article