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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew, Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W, Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R, Ray, William J
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
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Journal Article
The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4 H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine
Smith, Sean M., Uslaner, Jason M., Yao, Lihang, Mullins, Chadwick M., Surles, Nathan O., Huszar, Sarah L., McNaughton, Caitlyn H., Pascarella, Danette M., Kandebo, Monika, Hinchliffe, Richard M., Sparey, Tim, Brandon, Nicholas J., Jones, Brian, Venkatraman, Shankar, Young, Mary Beth, Sachs, Nancy, Jacobson, Marlene A., Hutson, Peter H.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2009)
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Journal Article
N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity
Sur, Cyrille, Mallorga, Pierre J., Wittmann, Marion, Jacobson, Marlene A., Pascarella, Danette, Williams, Jacinta B., Brandish, Philip E., Pettibone, Douglas J., Scolnick, Edward M., Conn, P. Jeffrey
Published in Proceedings of the National Academy of Sciences - PNAS (11.11.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (11.11.2003)
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Journal Article
The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site
Jacobson, Marlene A., Kreatsoulas, Constantine, Pascarella, Danette M., O’Brien, Julie A., Sur, Cyrille
Published in Molecular pharmacology (01.10.2010)
Published in Molecular pharmacology (01.10.2010)
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Journal Article
The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors
Sparey, Tim, Abeywickrema, Pravien, Almond, Sarah, Brandon, Nick, Byrne, Noel, Campbell, Alister, Hutson, Pete H., Jacobson, Marlene, Jones, Brian, Munshi, Sanjeev, Pascarella, Danette, Pike, Andrew, Prasad, G. Sridhar, Sachs, Nancy, Sakatis, Melanie, Sardana, Vinod, Venkatraman, Shankar, Young, Mary Beth
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin
Pettibone, Douglas J., Hess, J. Fred, Hey, Patricia J., Jacobson, Marlene A., Leviten, Michael, Lis, Edward V., Mallorga, Pierre J., Pascarella, Danette M., Snyder, Melissa A., Williams, Jacinta B., Zeng, Zhizhen
Published in The Journal of pharmacology and experimental therapeutics (01.01.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2002)
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Journal Article
Selective activation of the M 1 muscarinic acetylcholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew A., Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W., Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R., Ray, William J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
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Journal Article
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc‑1 Inhibitors Distinct from Traditional High Throughput Screening
Kutchukian, Peter S, Warren, Lee, Magliaro, Brian C, Amoss, Adam, Cassaday, Jason A, O’Donnell, Gregory, Squadroni, Brian, Zuck, Paul, Pascarella, Danette, Culberson, J. Chris, Cooke, Andrew J, Hurzy, Danielle, Schlegel, Kelly-Ann Sondra, Thomson, Fiona, Johnson, Eric N, Uebele, Victor N, Hermes, Jeffrey D, Parmentier-Batteur, Sophie, Finley, Michael
Published in ACS chemical biology (17.02.2017)
Published in ACS chemical biology (17.02.2017)
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Journal Article
The M1 muscarinic receptor allosteric agonists AC-42 and 1-1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site
Jacobson, Marlene A, Kreatsoulas, Constantine, Pascarella, Danette M, O'Brien, Julie A, Sur, Cyrille
Published in Molecular pharmacology (01.10.2010)
Published in Molecular pharmacology (01.10.2010)
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Journal Article
The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1'-(2-Methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzi m idazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site
Jacobson, Marlene A, Kreatsoulas, Constantine, Pascarella, Danette M, O'Brien, Julie A, Sur, Cyrille
Published in Molecular pharmacology (01.01.2010)
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Published in Molecular pharmacology (01.01.2010)
Journal Article
Selective activation of the M^sub 1^ muscarinic acetyicholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew, Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W, Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R, Ray, William J
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Journal Article
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 4H-thieno 3,2-bpyrrole-5-carboxylic acid and D-serine
Smith, Sean M, Uslaner, Jason M, Yao, Lihang, Mullins, Chadwick M, Surles, Nathan O, Huszar, Sarah L, McNaughton, Caitlyn H, Pascarella, Danette M, Kandebo, Monika, Hinchliffe, Richard M, Sparey, Tim, Brandon, Nicholas J, Jones, Brian, Venkatraman, Shankar, Young, Mary Beth, Sachs, Nancy, Jacobson, Marlene A, Hutson, Peter H
Published in The Journal of pharmacology and experimental therapeutics (01.03.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2009)
Get full text
Journal Article
Selective activation of the Mâ muscarinic acetylcholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew, Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W, Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R, Ray, William J
Published in Proceedings of the National Academy of Sciences - PNAS (2009)
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Published in Proceedings of the National Academy of Sciences - PNAS (2009)
Journal Article
Selective activation of the M sub(1) muscarinic acetylcholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew A, Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W, Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R, Ray, William J
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (01.01.2009)
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Journal Article
P4-305: Allosteric potentiation of the M1 muscarinic receptor provides unprecedented selectivity and a novel therapeutic strategy for the treatment of Alzheimer's disease
Ray, William J, Seager, Matthew, Ma, Lei, Wittmann, Marion, Getty, Krista, Marlatt, Michael, Crouthamel, Ming-Chih, Wu, Guoxin, Sankaranarayananan, Sethu, Simon, Adam, Burno, Maryann, Jones, Keith, Graufields, Valerie Kuzmick, Bickel, Denise, Posavec, Diane, Cook, Jacquelynn, Veng, Lone, Kuduk, Scott, Sur, Cyrille, Shipe, William, Lindsley, Craig, Kinney, Gene, Pascarella, Danette, Jacobson, Marlene, Seabrook, Guy
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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Journal Article