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Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells
Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco
Published in Nature medicine (01.05.2021)
Published in Nature medicine (01.05.2021)
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Journal Article
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Zhang, Yunlin, Patel, Ruchi P., Kim, Ki Hyun, Cho, Hyungwoo, Jo, Jae-Cheol, Jeong, Seong Hyun, Oh, Sung Yong, Choi, Yoon Seok, Kim, Sung Hyun, Lee, Ji Hyun, Angelos, Mathew, Guruprasad, Puneeth, Cohen, Ivan, Ugwuanyi, Ositadimma, Lee, Yong Gu, Pajarillo, Raymone, Cho, Jong Hyun, Carturan, Alberto, Paruzzo, Luca, Ghilardi, Guido, Wang, Michael, Kim, Soohwan, Kim, Sung-Min, Lee, Hyun-Jong, Park, Ji-Ho, Cui, Leiguang, Lee, Tae Bum, Hwang, In-Sik, Lee, Young-Ha, Lee, Yong-Jun, Porazzi, Patrizia, Liu, Dongfang, Lee, Yoon, Kim, Jong-Hoon, Lee, Jong-Seo, Yoon, Dok Hyun, Chung, Junho, Ruella, Marco
Published in Molecular cancer (09.12.2023)
Published in Molecular cancer (09.12.2023)
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Journal Article
Efficacy and safety of bendamustine for lymphodepletion before lisocabtagene maraleucel
Ghilardi, Guido, Paruzzo, Luca, Patel, Vrutti, Svoboda, Jakub, Chong, Emeline R., Fardella, Eugenio, Chong, Elise A., Gabrielli, Giulia, Nasta, Sunita D., Landsburg, Daniel J., Carter, Jordan, Pajarillo, Raymone, Barta, Stefan K., White, Griffin, Weber, Elizabeth, Napier, Ellen, Porter, David L., Garfall, Alfred L., Schuster, Stephen J., Ruella, Marco
Published in Journal of hematology and oncology (22.04.2024)
Published in Journal of hematology and oncology (22.04.2024)
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Journal Article
Apoptosis: a Janus bifrons in T-cell immunotherapy
Lee, Yong Gu, Yang, Nicholas, Chun, Inkook, Porazzi, Patrizia, Carturan, Alberto, Paruzzo, Luca, Sauter, Christopher Tor, Guruprasad, Puneeth, Pajarillo, Raymone, Ruella, Marco
Published in Journal for immunotherapy of cancer (01.04.2023)
Published in Journal for immunotherapy of cancer (01.04.2023)
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Journal Article
T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy
Ghilardi, Guido, Fraietta, Joseph A., Gerson, James N., Van Deerlin, Vivianna M., Morrissette, Jennifer J. D., Caponetti, Gabriel C., Paruzzo, Luca, Harris, Jaryse C., Chong, Elise A., Susanibar Adaniya, Sandra P., Svoboda, Jakub, Nasta, Sunita D., Ugwuanyi, Ositadimma H., Landsburg, Daniel J., Fardella, Eugenio, Waxman, Adam J., Chong, Emeline R., Patel, Vrutti, Pajarillo, Raymone, Kulikovskaya, Irina, Lieberman, David B., Cohen, Adam D., Levine, Bruce L., Stadtmauer, Edward A., Frey, Noelle V., Vogl, Dan T., Hexner, Elizabeth O., Barta, Stefan K., Porter, David L., Garfall, Alfred L., Schuster, Stephen J., June, Carl H., Ruella, Marco
Published in Nature medicine (01.04.2024)
Published in Nature medicine (01.04.2024)
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Journal Article
Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Singh, Nathan, Lee, Yong Gu, Shestova, Olga, Ravikumar, Pranali, Hayer, Katharina E., Hong, Seok Jae, Lu, Xueqing Maggie, Pajarillo, Raymone, Agarwal, Sangya, Kuramitsu, Shunichiro, Orlando, Elena J., Mueller, Karen Thudium, Good, Charly R., Berger, Shelley L., Shalem, Ophir, Weitzman, Matthew D., Frey, Noelle V., Maude, Shannon L., Grupp, Stephan A., June, Carl H., Gill, Saar, Ruella, Marco
Published in Cancer discovery (01.04.2020)
Published in Cancer discovery (01.04.2020)
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Journal Article
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
Smith, Melody, Dai, Anqi, Ghilardi, Guido, Amelsberg, Kimberly V., Devlin, Sean M., Pajarillo, Raymone, Slingerland, John B., Beghi, Silvia, Herrera, Pamela S., Giardina, Paul, Clurman, Annelie, Dwomoh, Emmanuel, Armijo, Gabriel, Gomes, Antonio L. C., Littmann, Eric R., Schluter, Jonas, Fontana, Emily, Taur, Ying, Park, Jae H., Palomba, Maria Lia, Halton, Elizabeth, Ruiz, Josel, Jain, Tania, Pennisi, Martina, Afuye, Aishat Olaide, Perales, Miguel-Angel, Freyer, Craig W., Garfall, Alfred, Gier, Shannon, Nasta, Sunita, Landsburg, Daniel, Gerson, James, Svoboda, Jakub, Cross, Justin, Chong, Elise A., Giralt, Sergio, Gill, Saar I., Riviere, Isabelle, Porter, David L., Schuster, Stephen J., Sadelain, Michel, Frey, Noelle, Brentjens, Renier J., June, Carl H., Pamer, Eric G., Peled, Jonathan U., Facciabene, Andrea, van den Brink, Marcel R. M., Ruella, Marco
Published in Nature medicine (01.04.2022)
Published in Nature medicine (01.04.2022)
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Journal Article
Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer
Lee, Yong Gu, Guruprasad, Puneeth, Ghilardi, Guido, Pajarillo, Raymone, Sauter, Christopher Tor, Patel, Ruchi, Ballard, Hatcher J., Hong, Seok Jae, Chun, Inkook, Yang, Nicholas, Amelsberg, Kimberly V., Cummins, Katherine D., Svoboda, Jakub, Gill, Saar, Chong, Elise A., North, Khrystyna, Church, Sarah E., Fraietta, Joseph A., Chang, Wan-Jung, Lacey, Simon F., Lu, Xueqing Maggie, Zhang, Yunlin, Whig, Kanupriya, Schultz, David C., Cherry, Sara, Gerson, James, Schuster, Stephen J., Porazzi, Patrizia, Ruella, Marco
Published in Cancer discovery (05.10.2022)
Published in Cancer discovery (05.10.2022)
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Journal Article
Overcoming the Lack of CD2:CD58 Costimulation in Chimeric Antigen Receptor T-Cell Immunotherapies
Carturan, Alberto, Angelos, Mathew G., Pajarillo, Raymone, Rodriguez, Jesse, Harris, Jaryse, Zhang, Yunlin, Singh, Ekta, Lee, Andrew, Ugwuanyi, Ositadimma, Patel, Ruchi P., Guruprasad, Puneeth, Lemoine, Jean, Cho, Jong Hyun, Porazzi, Patrizia, Schuster, Stephen J., Ruella, Marco
Published in Blood (05.11.2024)
Published in Blood (05.11.2024)
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Journal Article
Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy
Uribe-Herranz, Mireia, Beghi, Silvia, Ruella, Marco, Parvathaneni, Kalpana, Salaris, Silvano, Kostopoulos, Nektarios, George, Subin S., Pierini, Stefano, Krimitza, Elisavet, Costabile, Francesca, Ghilardi, Guido, Amelsberg, Kimberly V., Lee, Yong Gu, Pajarillo, Raymone, Markmann, Caroline, McGettigan-Croce, Bevin, Agarwal, Divyansh, Frey, Noelle, Lacey, Simon F., Scholler, John, Gabunia, Khatuna, Wu, Gary, Chong, Elise, Porter, David L., June, Carl H., Schuster, Stephen J., Bhoj, Vijay, Facciabene, Andrea
Published in Molecular therapy (01.03.2023)
Published in Molecular therapy (01.03.2023)
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Journal Article
Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell Immunotherapies
Patel, Ruchi P., Ghilardi, Guido, Zhang, Yunlin, Guruprasad, Puneeth, Angelos, Mathew G., Pajarillo, Raymone, Gabunia, Khatuna, Xu, Chong, Blanchard, Tatiana, Scholler, John, Porazzi, Patrizia, Linette, Gerald, Carreno, Beatriz M., Ruella, Marco
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Fratricide-Resistant Anti-CD2 Chimeric Antigen Receptor T-Cells with Endogenous CD2 Knockout Are Highly Effective Against T-Cell Neoplasms
Angelos, Mathew G., Patel, Ruchi P., Chiang, Yi-Hao, Xie, Wei, Pajarillo, Raymone, Shaw, Carolyn E., Singh, Ekta, Xu, Jason, Posey, Avery D., Rook, Alain, Rotolo, Antonia, Pillai, Vinodh, Pileri, Stefano A., Teachey, David T., Ruella, Marco
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
Porazzi, Patrizia, Nason, Siena, Yang, Ziqi, Carturan, Alberto, Ghilardi, Guido, Guruprasad, Puneeth, Patel, Ruchi P., Tan, Melody, Padmanabhan, Anushka Anant, Lemoine, Jean, Fardella, Eugenio, Zhang, Yunlin, Pajarillo, Raymone, Chen, Linhui, Ugwuanyi, Ositadimma, Markowitz, Kelly, Delman, Devora, Angelos, Mathew G., Shestova, Olga, Isshiki, Yusuke, Blanchard, Tatiana, Béguelin, Wendy, Melnick, Ari M., Linette, Gerald P., Beatty, Gregory L., Carreno, Beatriz M., Cohen, Ivan J., Paruzzo, Luca, Schuster, Stephen J., Ruella, Marco
Published in Cancer cell (10.03.2025)
Published in Cancer cell (10.03.2025)
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Journal Article
Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy
Tang, Yan, Liu, Wei, Kadu, Siddhant, Johnson, Omar, Hasanali, Zainul S., Kelly, Andre, Shestov, Alexander, Greenblatt, Eli, Holmes, Matthew, Wang, Li-Ping, Shih, Natalie, O’Connor, Roddy S., Garfall, Alfred L., Allman, David, Vogl, Dan T., Cohen, Adam, June, Carl H., Sheppard, Neil C.
Published in Blood (11.01.2024)
Published in Blood (11.01.2024)
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Journal Article
CD5-Deleted Chimeric Antigen Receptor Cells (Senza5™ CART5) to Enhance Immunotherapy Against T-Cell Non-Hodgkin Lymphoma: A First-in-Human Phase I Clinical Trial
Barta, Stefan K., Ruella, Marco, Schuster, Stephen J., Svoboda, Jakub, Carter, Jordan, Chong, Elise A., Landsburg, Daniel J., Nasta, Sunita D., Thomas, Colin, Patel, Ruchi P., Ghilardi, Guido, Porazzi, Patrizia, Yang, Steven, Qian, Dean, Pajarillo, Raymone, Zhang, Yunlin, Nimmagadda, Aditya, Vu, Trang, Peddada, Lavanya, Snook, Adam E., Siciliano, Nicholas A., Mazanet, Rosemary
Published in Blood (05.11.2024)
Published in Blood (05.11.2024)
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Journal Article
Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate
Liu, Shan, Guruprasad, Puneeth, Han, Kecheng, Paruzzo, Luca, Shestov, Alexander, Kelly, Andre, Amses, Kevin R., Afriat, Amichay, Madhu, Bhoomi, Litichevskiy, Lev, Dubowitz, Ezra, Tangal, Neil, McSween, Alana, Tan, Melody, Carturan, Alberto, Lee, Andrew, Zhang, Yunlin, Gabrielli, Giulia, Pajarillo, Raymone, Patel, Ruchi P., Ghilardi, Guido, Porazzi, Patrizia, Schuster, Stephen J., O'Connor, Roddy S., Milone, Michael C., Rabinowitz, Joshua, Levy, Maayan, Ruella, Marco
Published in Blood (05.11.2024)
Published in Blood (05.11.2024)
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Journal Article
Clinical Development of Senza5TM CART5: a Novel Dual Population CD5 CRISPR-Cas9 Knocked out Anti-CD5 Chimeric Antigen Receptor T Cell Product for Relapsed and Refractory CD5+ Nodal T-Cell Lymphomas
Patel, Ruchi P., Ghilardi, Guido, Porazzi, Patrizia, Yang, Steven, Qian, Dean, Pajarillo, Raymone, Wang, Michael, Zhang, Yunlin, Schuster, Stephen J., Barta, Stefan K., Nimmagadda, Aditya, Snook, Adam, Siciliano, Nicholas A., Ruella, Marco
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
The BTLA–HVEM axis restricts CAR T cell efficacy in cancer
Guruprasad, Puneeth, Carturan, Alberto, Zhang, Yunlin, Cho, Jong Hyun, Kumashie, Kingsley Gideon, Patel, Ruchi P., Kim, Ki-Hyun, Lee, Jong-Seo, Lee, Yoon, Kim, Jong Hoon, Chung, Junho, Joshi, Akshita, Cohen, Ivan, Shestov, Maksim, Ghilardi, Guido, Harris, Jaryse, Pajarillo, Raymone, Angelos, Mathew, Lee, Yong Gu, Liu, Shan, Rodriguez, Jesse, Wang, Michael, Ballard, Hatcher J., Gupta, Aasha, Ugwuanyi, Ositadimma H., Hong, Seok Jae Albert, Bochi-Layec, Audrey C., Sauter, Christopher T., Chen, Linhui, Paruzzo, Luca, Kammerman, Shane, Shestova, Olga, Liu, Dongfang, Vella, Laura A., Schuster, Stephen J., Svoboda, Jakub, Porazzi, Patrizia, Ruella, Marco
Published in Nature immunology (01.06.2024)
Published in Nature immunology (01.06.2024)
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Journal Article
Efficacy and Safety of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor (CAR) T-Cell Therapies in Patients with Autoimmune Disease and Lymphoma or Myeloma
Paruzzo, Luca, Bouvier, Riemke, Ghilardi, Guido, Fardella, Eugenio, Fulmer, Bria, Cohen, Ivan J, Chong, Elise A., Svoboda, Jakub, Nasta, Sunita D., Landsburg, Daniel J., Patel, Vrutti, Ziyu, Li, Pajarillo, Raymone, Waxman, Adam, Cohen, Adam D., Vogl, Dan T., Barta, Stefan K., Porazzi, Patrizia, Fraietta, Joseph A., Bhoj, Vijay, Garfall, Alfred L., Stadtmauer, Edward A., Schuster, Stephen J., Carter, Jordan S., Apostolidis, Sokratis A., Susanibar-Adaniya, Sandra, Ruella, Marco
Published in Blood (05.11.2024)
Published in Blood (05.11.2024)
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Journal Article
Precision Targeting of the Malignant Clone in Diffuse Large B Cell Lymphoma Using Chimeric Antigen Receptor T Cells Against the Clonotypic IGHV4-34 B Cell Receptor
Cohen, Ivan J, Bochi-Layec, Audrey C, Kim, Ki Hyun, Jenks, Scott, Ugwuanyi, Ositadimma, Ghilardi, Guido, Gabrielli, Giulia, Harris, Jaryse, Wang, Li-Ping, Zhang, Yunlin, Pajarillo, Raymone, Vlachonikola, Elisavet, Porazzi, Patrizia, Sanz, Ignacio, Ghia, Paolo, Stamatopoulos, Kostas, Schuster, Stephen J, Ruella, Marco
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article