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A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics
Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Kos-van Oosterhoud, Janneke, Feijt, Carola, Jochems, Simon P., de Dood, Claudia J., van Schuijlenburg, Roos, Ozir-Fazalalikhan, Arifa, Manurung, Mikhael D., Sartono, Erliyani, van der Beek, Martha T., Winkel, Béatrice M. F., Verbeek-Menken, Petra H., Stam, Koen A., van Leeuwen, Fijs W. B., Meij, Pauline, van Diepen, Angela, van Lieshout, Lisette, van Dam, Govert J., Corstjens, Paul L. A. M., Hokke, Cornelis H., Yazdanbakhsh, Maria, Visser, Leo G., Roestenberg, Meta
Published in Nature medicine (01.03.2020)
Published in Nature medicine (01.03.2020)
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Journal Article
Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs
Obieglo, Katja, Costain, Alice, Webb, Lauren M., Ozir‐Fazalalikhan, Arifa, Brown, Shelia L., MacDonald, Andrew S., Smits, Hermelijn H.
Published in European journal of immunology (01.08.2019)
Published in European journal of immunology (01.08.2019)
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Journal Article
Early expansion of allergen‐responsive LAP+ B regulatory cells in allergic rhinitis but not in allergic asthma subjects during allergen immunotherapy
Voskamp, Astrid L., Jong, Nicolette W., Jochems, Simon P., Ozir‐Fazalalikhan, Arifa, Hengel, Oscar R. J., Vlugt, Luciën E. P. M., Stam, Koen Alexander, Berge, Maarten, Nawijn, Martijn C., Braunstahl, Gert‐Jan, Möller, Gertrude M., Wijk, Roy Gerth, Smits, Hermelijn H.
Published in Allergy (Copenhagen) (01.04.2024)
Published in Allergy (Copenhagen) (01.04.2024)
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Journal Article
Isolated Schistosoma mansoni eggs prevent allergic airway inflammation
Obieglo, Katja, Schuijs, Martijn J., Ozir‐Fazalalikhan, Arifa, Otto, Frank, Wijck, Yolanda, Boon, Louis, Lambrecht, Bart N., Taube, Christian, Smits, Hermelijn H.
Published in Parasite immunology (01.10.2018)
Published in Parasite immunology (01.10.2018)
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Journal Article
DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells
Kuipers, Marije E., Nolte-'t Hoen, Esther N.M., van der Ham, Alwin J., Ozir-Fazalalikhan, Arifa, Nguyen, D. Linh, de Korne, Clarize M., Koning, Roman I., Tomes, John J., Hoffmann, Karl F., Smits, Hermelijn H., Hokke, Cornelis H.
Published in Journal of extracellular vesicles (01.01.2020)
Published in Journal of extracellular vesicles (01.01.2020)
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Journal Article
The helminth glycoprotein omega‐1 improves metabolic homeostasis in obese mice through type 2 immunity‐independent inhibition of food intake
Zande, Hendrik J.P., Gonzalez, Michael A., Ruiter, Karin, Wilbers, Ruud H.P., García‐Tardón, Noemí, Huizen, Mariska, Noort, Kim, Pelgrom, Leonard R., Lambooij, Joost M., Zawistowska‐Deniziak, Anna, Otto, Frank, Ozir‐Fazalalikhan, Arifa, Willigen, Danny, Welling, Mick, Poles, Jordan, Leeuwen, Fijs, Hokke, Cornelis H., Schots, Arjen, Yazdanbakhsh, Maria, Loke, P'ng, Guigas, Bruno
Published in The FASEB journal (01.02.2021)
Published in The FASEB journal (01.02.2021)
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Journal Article
Extracellular Vesicles From Schistosoma mansoni Adult Worms Stimulate IL ‐10 Release by B Cells
Kuipers, Marije E., Ozir‐Fazalalikhan, Arifa, Haeberlein, Simone, Driessen, Nicole N., de Korne, Clarize M., Mes, Lynn, Hensbergen, Paul J., Nolte‐’t Hoen, Esther N. M., Hokke, Cornelis H., Smits, Hermelijn H.
Published in Parasite immunology (01.09.2025)
Published in Parasite immunology (01.09.2025)
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Journal Article
LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells
Pelgrom, Leonard R., Patente, Thiago A., Sergushichev, Alexey, Esaulova, Ekaterina, Otto, Frank, Ozir-Fazalalikhan, Arifa, van der Zande, Hendrik J. P., van der Ham, Alwin J., van der Stel, Stefan, Artyomov, Maxim N., Everts, Bart
Published in Cell research (01.05.2019)
Published in Cell research (01.05.2019)
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Journal Article
Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells
Haeberlein, Simone, Obieglo, Katja, Ozir-Fazalalikhan, Arifa, Chayé, Mathilde A M, Veninga, Henrike, van der Vlugt, Luciën E P M, Voskamp, Astrid, Boon, Louis, den Haan, Joke M M, Westerhof, Lotte B, Wilbers, Ruud H P, Schots, Arjen, Schramm, Gabriele, Hokke, Cornelis H, Smits, Hermelijn H
Published in PLoS pathogens (01.07.2017)
Published in PLoS pathogens (01.07.2017)
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Journal Article
Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells
van der Vlugt, Luciën E P M, Labuda, Lucja A, Ozir-Fazalalikhan, Arifa, Lievers, Ellen, Gloudemans, Anouk K, Liu, Kit-Yeng, Barr, Tom A, Sparwasser, Tim, Boon, Louis, Ngoa, Ulysse Ateba, Feugap, Eliane Ngoune, Adegnika, Ayola A, Kremsner, Peter G, Gray, David, Yazdanbakhsh, Maria, Smits, Hermelijn H
Published in PloS one (2012)
Published in PloS one (2012)
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Journal Article
S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration
Patente, Thiago A., Gasan, Thomas A., Scheenstra, Maaike, Ozir-Fazalalikhan, Arifa, Obieglo, Katja, Schetters, Sjoerd, Verwaerde, Stijn, Vergote, Karl, Otto, Frank, Wilbers, Ruud H. P., van Bloois, Eline, Wijck, Yolanda van, Taube, Christian, Hammad, Hamida, Schots, Arjen, Everts, Bart, Yazdanbakhsh, Maria, Guigas, Bruno, Hokke, Cornelis H., Smits, Hermelijn H.
Published in PLoS pathogens (26.08.2024)
Published in PLoS pathogens (26.08.2024)
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Journal Article
mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming
Pelgrom, Leonard R., Patente, Thiago A., Otto, Frank, Nouwen, Lonneke V., Ozir-Fazalalikhan, Arifa, van der Ham, Alwin J., van der Zande, Hendrik J.P., Heieis, Graham A., Arens, Ramon, Everts, Bart
Published in Cell reports (Cambridge) (05.07.2022)
Published in Cell reports (Cambridge) (05.07.2022)
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Journal Article
Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load
Haeberlein, Simone, Chevalley-Maurel, Séverine, Ozir-Fazalalikhan, Arifa, Koppejan, Hester, Winkel, Beatrice M. F., Ramesar, Jai, Khan, Shahid M., Sauerwein, Robert W., Roestenberg, Meta, Janse, Chris J., Smits, Hermelijn H., Franke-Fayard, Blandine
Published in Scientific reports (04.09.2017)
Published in Scientific reports (04.09.2017)
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Journal Article
Dendritic cell–intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity
van der Zande, Hendrik J.P., Brombacher, Eline C., Lambooij, Joost M., Pelgrom, Leonard R., Zawistowska-Deniziak, Anna, Patente, Thiago A., Heieis, Graham A., Otto, Frank, Ozir-Fazalalikhan, Arifa, Yazdanbakhsh, Maria, Everts, Bart, Guigas, Bruno
Published in JCI insight (08.06.2023)
Published in JCI insight (08.06.2023)
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Journal Article
The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-β
Gloudemans, Anouk K., Plantinga, Maud, Guilliams, Martin, Willart, Monique A., Ozir-Fazalalikhan, Arifa, van der Ham, Alwin, Boon, Louis, Harris, Nicola L., Hammad, Hamida, Hoogsteden, Henk C., Yazdanbakhsh, Maria, Hendriks, Rudi W., Lambrecht, Bart N., Smits, Hermelijn H.
Published in PloS one (20.03.2013)
Published in PloS one (20.03.2013)
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Journal Article
Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas
Chayé, Mathilde A M, van Hengel, Oscar R J, Voskamp, Astrid L, Ozir-Fazalalikhan, Arifa, König, Marion H, Stam, Koen A, Manurung, Mikhael D, Mouwenda, Yoanne D, Aryeetey, Yvonne A, Kurniawan, Agnes, Kruize, Yvonne C M, Sartono, Erliyani, Buisman, Anne-Marie, Yazdanbakhsh, Maria, Tak, Tamar, Smits, Hermelijn H
Published in Clinical and experimental immunology (21.01.2025)
Published in Clinical and experimental immunology (21.01.2025)
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Journal Article
Interleukin 10 (IL-10)–Producing CD1dhi Regulatory B Cells From Schistosoma Haematobium–Infected Individuals Induce IL-10–Positive T Cells and Suppress Effector T-Cell Cytokines
van der Vlugt, Luciën E. P. M., Zinsou, Jeannot F., Ozir-Fazalalikhan, Arifa, Kremsner, Peter G., Yazdanbakhsh, Maria, Adegnika, Ayola A., Smits, Hermelijn H.
Published in The Journal of infectious diseases (15.10.2014)
Published in The Journal of infectious diseases (15.10.2014)
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Journal Article
Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures
Casacuberta-Partal, Miriam, van Lieshout, Lisette, van Diepen, Angela, Sijtsma, Jeroen C., Ozir-Fazalalikhan, Arifa, Koopman, Jan Pieter R., de Dood, Claudia J., Corstjens, Paul L.A.M., van Dam, Govert J., Hokke, Cornelis H., Roestenberg, Meta
Published in Parasitology (01.03.2022)
Published in Parasitology (01.03.2022)
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Journal Article
Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model
Janse, Jacqueline J, Langenberg, Marijke C C, Kos-Van Oosterhoud, Janneke, Ozir-Fazalalikhan, Arifa, Brienen, Eric A T, Winkel, Béatrice M F, Erkens, Marianne A A, van der Beek, Martha T, van Lieshout, Lisette, Smits, Hermelijn H, Webster, Bonnie L, Zandvliet, Maarten L, Verbeek, Richard, Westra, Inge M, Meij, Pauline, Visser, Leo G, van Diepen, Angela, Hokke, Cornelis H, Yazdanbakhsh, Maria, Roestenberg, Meta
Published in The Journal of infectious diseases (24.08.2018)
Published in The Journal of infectious diseases (24.08.2018)
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Journal Article
Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells
Chayé, Mathilde A. M., Gasan, Thomas A., Ozir-Fazalalikhan, Arifa, Scheenstra, Maaike R., Zawistowska-Deniziak, Anna, van Hengel, Oscar R. J., Gentenaar, Max, Manurung, Mikhael D., Harvey, Michael R., Codée, Jeroen D. C., Chiodo, Fabrizio, Heijke, Anouk M., Kalinowska, Alicja, van Diepen, Angela, Hensbergen, Paul J., Yazdanbakhsh, Maria, Guigas, Bruno, Hokke, Cornelis H., Smits, Hermelijn H.
Published in PLoS neglected tropical diseases (01.06.2023)
Published in PLoS neglected tropical diseases (01.06.2023)
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Journal Article