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Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial
Poelgeest, Eveline P., Hodges, Michael R., Moerland, Matthijs, Tessier, Yann, Levin, Arthur A., Persson, Robert, Lindholm, Marie W., Dumong Erichsen, Kamille, Ørum, Henrik, Cohen, Adam F., Burggraaf, Jacobus
Published in British journal of clinical pharmacology (01.12.2015)
Published in British journal of clinical pharmacology (01.12.2015)
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Journal Article
The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials
Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Published in Nucleic acid therapeutics (01.06.2017)
Published in Nucleic acid therapeutics (01.06.2017)
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Journal Article
Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen
McCaleb, Michael L., Hughes, Steven G., Grossman, Tamar R., Frazer-Abel, Ashley, Jung, Bill, Yin, Lixuan, Henry, Scott P., Monia, Brett P., Schneider, Eugene, Geary, Richard, Brice, Gary T.
Published in Immunobiology (1979) (01.03.2025)
Published in Immunobiology (1979) (01.03.2025)
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Journal Article
Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events
Partridge, Wesley, Burel, Sebastien A., Ferng, Annie, Xia, Shuting, Kwoh, T. Jesse, Henry, Scott P., Baker, Brenda F.
Published in Clinical and translational science (01.04.2023)
Published in Clinical and translational science (01.04.2023)
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Journal Article
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
Tebas, Pablo, Stein, David, Binder-Scholl, Gwendolyn, Mukherjee, Rithun, Brady, Troy, Rebello, Tessio, Humeau, Laurent, Kalos, Michael, Papasavvas, Emmanouil, Montaner, Luis J., Schullery, Daniel, Shaheen, Farida, Brennan, Andrea L., Zheng, Zhaohui, Cotte, Julio, Slepushkin, Vladimir, Veloso, Elizabeth, Mackley, Adonna, Hwang, Wei-Ting, Aberra, Faten, Zhan, Jenny, Boyer, Jean, Collman, Ronald G., Bushman, Frederic D., Levine, Bruce L., June, Carl H.
Published in Blood (28.02.2013)
Published in Blood (28.02.2013)
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Journal Article
A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in Patients With Localized Prostate Cancer
Chi, Kim N., Eisenhauer, Elizabeth, Fazli, Ladan, Jones, Edward C., Goldenberg, S. Larry, Powers, Jean, Tu, Dongsheng, Gleave, Martin E.
Published in JNCI : Journal of the National Cancer Institute (07.09.2005)
Published in JNCI : Journal of the National Cancer Institute (07.09.2005)
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Journal Article
TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge
Imaoka, H., Campbell, H., Babirad, I., Watson, R. M., Mistry, M., Sehmi, R., Gauvreau, G. M.
Published in Clinical and experimental allergy (01.12.2011)
Published in Clinical and experimental allergy (01.12.2011)
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Journal Article
Impact of dosing regimen of custirsen, an antisense oligonucleotide, on safety, tolerability and cardiac repolarization in healthy subjects
Rabinovich‐Guilatt, Laura, Elgart, Anna, Erisson, Lavi, Willsie, Sandra K., Tessler, Shoshi, Barnett‐Griness, Ofra, Pande, Amitkumar, Spiegelstein, Ofer
Published in British journal of clinical pharmacology (01.09.2015)
Published in British journal of clinical pharmacology (01.09.2015)
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Journal Article
Phase I Trial of ISIS 104838, a 2′-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-α
Sewell, K. Lea, Geary, Richard S., Baker, Brenda F., Glover, Josephine M., Mant, Timothy G.K., Yu, Rosie Z., Tami, Joseph A., Dorr, F. Andrew
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
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