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Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR
O'Reilly, Matthew C., Dong, Shi-Hui, Rossi, Francis M., Karlen, Kaleigh M., Kumar, Rohan S., Nair, Satish K., Blackwell, Helen E.
Published in Cell chemical biology (20.09.2018)
Published in Cell chemical biology (20.09.2018)
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Journal Article
Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values
Manson, Daniel E, O’Reilly, Matthew C, Nyffeler, Kayleigh E, Blackwell, Helen E
Published in ACS infectious diseases (10.04.2020)
Published in ACS infectious diseases (10.04.2020)
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Journal Article
Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells
O’Reilly, Matthew C, Scott, Sarah A, Brown, Kyle A, Oguin, Thomas H, Thomas, Paul G, Daniels, J. Scott, Morrison, Ryan, Brown, H. Alex, Lindsley, Craig W
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Journal Article
Evaluation of Antibacterial Functionalized Dihydropyrimidine Photoaffinity Probes Toward Mechanism of Action Studies
Russo, Christopher M., Boyer, Zachary W., Scheunemann, Kaitlyn, Farren, Jonathan, Minich, Alexandra, Wenthur, Cody J., O’Reilly, Matthew C.
Published in ACS medicinal chemistry letters (11.07.2024)
Published in ACS medicinal chemistry letters (11.07.2024)
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Journal Article
Discovery of Desketoraloxifene Analogues as Inhibitors of Mammalian, Pseudomonas aeruginosa, and NAPE Phospholipase D Enzymes
Scott, Sarah A, Spencer, Cierra T, O’Reilly, Matthew C, Brown, Kyle A, Lavieri, Robert R, Cho, Chul-Hee, Jung, Dai-Il, Larock, Richard C, Brown, H. Alex, Lindsley, Craig W
Published in ACS chemical biology (20.02.2015)
Published in ACS chemical biology (20.02.2015)
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Journal Article
Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure–Activity Relationships and Mechanism of Action
Boyer, Zachary W., Kessler, Hannah, Brosman, Hannah, Ruud, Kirsten J., Falkowski, Alan F., Viollet, Constance, Bourne, Christina R., O’Reilly, Matthew C.
Published in ACS omega (25.10.2022)
Published in ACS omega (25.10.2022)
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Journal Article
A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis
Senter, Timothy J., O’Reilly, Matthew C., Chong, Katherine M., Sulikowski, Gary A., Lindsley, Craig W.
Published in Tetrahedron letters (04.03.2015)
Published in Tetrahedron letters (04.03.2015)
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Journal Article
Discovery of a Highly Selective PLD2 Inhibitor (ML395): A New Probe with Improved Physiochemical Properties and Broad-Spectrum Antiviral Activity against Influenza Strains
O'Reilly, Matthew C., Oguin III, Thomas H., Scott, Sarah A., Thomas, Paul G., Locuson, Charles W., Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.
Published in ChemMedChem (01.12.2014)
Published in ChemMedChem (01.12.2014)
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Journal Article
Regulation of Phospholipase D Activity and Phosphatidic Acid Production after Purinergic (P2Y6) Receptor Stimulation
Scott, Sarah A., Xiang, Yun, Mathews, Thomas P., Cho, Hyekyung P., Myers, David S., Armstrong, Michelle D., Tallman, Keri A., O'Reilly, Matthew C., Lindsley, Craig W., Brown, H. Alex
Published in The Journal of biological chemistry (12.07.2013)
Published in The Journal of biological chemistry (12.07.2013)
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Journal Article
Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC 50 Values
Manson, Daniel E., O’Reilly, Matthew C., Nyffeler, Kayleigh E., Blackwell, Helen E.
Published in ACS infectious diseases (10.04.2020)
Published in ACS infectious diseases (10.04.2020)
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Journal Article