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Sour Sensing from the Tongue to the Brain
Zhang, Jin, Jin, Hao, Zhang, Wenyi, Ding, Cheng, O’Keeffe, Sean, Ye, Mingyu, Zuker, Charles S.
Published in Cell (03.10.2019)
Published in Cell (03.10.2019)
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Journal Article
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
Gerbino, Valeria, Kaunga, Esther, Ye, Junqiang, Canzio, Daniele, O’Keeffe, Sean, Rudnick, Noam D., Guarnieri, Paolo, Lutz, Cathleen M., Maniatis, Tom
Published in Neuron (Cambridge, Mass.) (03.06.2020)
Published in Neuron (Cambridge, Mass.) (03.06.2020)
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Journal Article
Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly
Mountoufaris, George, Chen, Weisheng V., Hirabayashi, Yusuke, O’Keeffe, Sean, Chevee, Maxime, Nwakeze, Chiamaka L., Polleux, Franck, Maniatis, Tom
Published in Science (American Association for the Advancement of Science) (28.04.2017)
Published in Science (American Association for the Advancement of Science) (28.04.2017)
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Journal Article
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Chiu, Isaac M., Morimoto, Emiko T.A., Goodarzi, Hani, Liao, Jennifer T., O’Keeffe, Sean, Phatnani, Hemali P., Muratet, Michael, Carroll, Michael C., Levy, Shawn, Tavazoie, Saeed, Myers, Richard M., Maniatis, Tom
Published in Cell reports (Cambridge) (25.07.2013)
Published in Cell reports (Cambridge) (25.07.2013)
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Journal Article
Exome sequencing and characterization of 49,960 individuals in the UK Biobank
Van Hout, Cristopher V., Tachmazidou, Ioanna, Backman, Joshua D., Hoffman, Joshua D., Liu, Daren, Pandey, Ashutosh K., Gonzaga-Jauregui, Claudia, Khalid, Shareef, Ye, Bin, Banerjee, Nilanjana, Li, Alexander H., O’Dushlaine, Colm, Marcketta, Anthony, Staples, Jeffrey, Schurmann, Claudia, Hawes, Alicia, Maxwell, Evan, Barnard, Leland, Lopez, Alexander, Penn, John, Habegger, Lukas, Blumenfeld, Andrew L., Bai, Xiaodong, O’Keeffe, Sean, Yadav, Ashish, Praveen, Kavita, Jones, Marcus, Salerno, William J., Chung, Wendy K., Surakka, Ida, Willer, Cristen J., Hveem, Kristian, Leader, Joseph B., Carey, David J., Ledbetter, David H., Cardon, Lon, Yancopoulos, George D., Economides, Aris, Coppola, Giovanni, Shuldiner, Alan R., Balasubramanian, Suganthi, Cantor, Michael, Nelson, Matthew R., Whittaker, John, Reid, Jeffrey G., Marchini, Jonathan, Overton, John D., Scott, Robert A., Abecasis, Gonçalo R., Yerges-Armstrong, Laura, Baras, Aris
Published in Nature (London) (29.10.2020)
Published in Nature (London) (29.10.2020)
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Journal Article
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Ye, Chen, Kenian, Sloan, Steven A., Bennett, Mariko L., Scholze, Anja R., O'Keeffe, Sean, Phatnani, Hemali P., Guarnieri, Paolo, Caneda, Christine, Ruderisch, Nadine, Deng, Shuyun, Liddelow, Shane A., Zhang, Chaolin, Daneman, Richard, Maniatis, Tom, Barres, Ben A., Wu, Jia Qian
Published in The Journal of neuroscience (03.09.2014)
Published in The Journal of neuroscience (03.09.2014)
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Journal Article
Common and rare variant associations with clonal haematopoiesis phenotypes
Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., Jorgenson, Eric
Published in Nature (London) (08.12.2022)
Published in Nature (London) (08.12.2022)
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Journal Article
Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome
Sultan, Marc, Schulz, Marcel H, Richard, Hugues, Magen, Alon, Klingenhoff, Andreas, Scherf, Matthias, Seifert, Martin, Borodina, Tatjana, Soldatov, Aleksey, Parkhomchuk, Dmitri, Schmidt, Dominic, O'Keeffe, Sean, Haas, Stefan, Vingron, Martin, Lehrach, Hans, Yaspo, Marie-Laure
Published in Science (American Association for the Advancement of Science) (15.08.2008)
Published in Science (American Association for the Advancement of Science) (15.08.2008)
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Journal Article
Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice
Canzio, Daniele, Nwakeze, Chiamaka L., Horta, Adan, Rajkumar, Sandy M., Coffey, Eliot L., Duffy, Erin E., Duffié, Rachel, Monahan, Kevin, O’Keeffe, Sean, Simon, Matthew D., Lomvardas, Stavros, Maniatis, Tom
Published in Cell (18.04.2019)
Published in Cell (18.04.2019)
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Journal Article
hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function
Ye, Junqiang, Beetz, Nadine, O’Keeffe, Sean, Tapia, Juan Carlos, Macpherson, Lindsey, Chen, Weisheng V., Bassel-Duby, Rhonda, Olson, Eric N., Maniatis, Tom
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.2015)
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Journal Article
Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice
Chen, Weisheng V., Nwakeze, Chiamaka L., Denny, Christine A., O’Keeffe, Sean, Rieger, Michael A., Mountoufaris, George, Kirner, Amy, Dougherty, Joseph D., Hen, René, Wu, Qiang, Maniatis, Tom
Published in Science (American Association for the Advancement of Science) (28.04.2017)
Published in Science (American Association for the Advancement of Science) (28.04.2017)
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Journal Article
Thermoplastic forming of bulk metallic glass—Applications for MEMS and microstructure fabrication
Schroers, Jan, Nguyen, Tranquoc, O’Keeffe, Sean, Desai, Amish
Published in Materials science & engineering. A, Structural materials : properties, microstructure and processing (01.03.2007)
Published in Materials science & engineering. A, Structural materials : properties, microstructure and processing (01.03.2007)
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Journal Article
Conference Proceeding
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
Kosmicki, Jack A., Horowitz, Julie E., Banerjee, Nilanjana, Lanche, Rouel, Marcketta, Anthony, Maxwell, Evan, Bai, Xiaodong, Sun, Dylan, Backman, Joshua D., Sharma, Deepika, Kury, Fabricio S.P., Kang, Hyun M., O’Dushlaine, Colm, Yadav, Ashish, Mansfield, Adam J., Li, Alexander H., Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Locke, Adam E., Khalid, Shareef, O’Keeffe, Sean, Mbatchou, Joelle, Chazara, Olympe, Huang, Yunfeng, Kvikstad, Erika, O’Neill, Amanda, Nioi, Paul, Parker, Meg M., Petrovski, Slavé, Runz, Heiko, Szustakowski, Joseph D., Wang, Quanli, Wong, Emily, Cordova-Palomera, Aldo, Smith, Erin N., Szalma, Sandor, Zheng, Xiuwen, Esmaeeli, Sahar, Davis, Justin W., Lai, Yi-Pin, Chen, Xing, Justice, Anne E., Leader, Joseph B., Mirshahi, Tooraj, Carey, David J., Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Rader, Daniel J., Povysil, Gundula, Goldstein, David B., Kiryluk, Krzysztof, Pairo-Castineira, Erola, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Meynert, Alison, Kousathanas, Athanasios, Moutsianas, Loukas, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Wilson, James F., Baillie, J. Kenneth, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Lathrop, Mark, Richards, J. Brent, Jones, Marcus, Balasubramanian, Suganthi, Salerno, William, Shuldiner, Alan R., Marchini, Jonathan, Overton, John D., Habegger, Lukas, Cantor, Michael N., Reid, Jeffrey G., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A.R.
Published in American journal of human genetics (01.07.2021)
Published in American journal of human genetics (01.07.2021)
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Journal Article
Intricate interplay between astrocytes and motor neurons in ALS
Phatnani, Hemali P., Guarnieri, Paolo, Friedman, Brad A., Carrasco, Monica A., Muratet, Michael, O’Keeffe, Sean, Nwakeze, Chiamaka, Pauli-Behn, Florencia, Newberry, Kimberly M., Meadows, Sarah K., Tapia, Juan Carlos, Myers, Richard M., Maniatis, Tom
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
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Journal Article
Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells
Amoroso, Mackenzie W., Croft, Gist F., Williams, Damian J., O'Keeffe, Sean, Carrasco, Monica A., Davis, Anne R., Roybon, Laurent, Oakley, Derek H., Maniatis, Tom, Henderson, Christopher E., Wichterle, Hynek
Published in The Journal of neuroscience (09.01.2013)
Published in The Journal of neuroscience (09.01.2013)
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Journal Article
Transcription factor binding predictions using TRAP for the analysis of ChIP-seq data and regulatory SNPs
Thomas-Chollier, Morgane, Hufton, Andrew, Heinig, Matthias, O'Keeffe, Sean, Masri, Nassim El, Roider, Helge G, Manke, Thomas, Vingron, Martin
Published in Nature protocols (01.12.2011)
Published in Nature protocols (01.12.2011)
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Journal Article
PASTAA: identifying transcription factors associated with sets of co-regulated genes
Roider, Helge G., Manke, Thomas, O'Keeffe, Sean, Vingron, Martin, Haas, Stefan A.
Published in Bioinformatics (15.02.2009)
Published in Bioinformatics (15.02.2009)
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Journal Article
Exclusion-based exome sequencing in critically ill adults 18–40 years old has a 24% diagnostic rate and finds racial disparities in access to genetic testing
Gold, Jessica I., Kripke, Colleen M., Li, Alexander, Lopez, Alexander, Hawes, Alicia, Averitt, Amelia, Damask, Amy, Deubler, Andrew, Marcketta, Anthony, Ayer, Ariane, Baras, Aris, Economides, Aris, Ghosh, Arkopravo, Guvenek, Aysegul, Ye, Bin, Zhang, Blair, Forsythe, Caitlin, Sidore, Carlo, Paulding, Charles, Beechert, Christina, Rader, Daniel J., Liu, Daren, Sharma, Deepika, Stahl, Eli, Fuller, Erin D., Chen, Esteban, Maxwell, Evan K., Coppola, Giovanni, Abecasis, Goncalo, Kang, Hyun Min, Hernandez, Jaimee, Mighty, Jason, Staples, Jeffrey C., Reid, Jeffrey G., Staples, Jeffrey, Mbatchou, Joelle, Overton, John D., Marchini, Jonathan, Bovijn, Jonas, Backman, Joshua, Siminovitch, Katherine, Praveen, Kavita, Manoochehri, Kia, Gurski, Lauren, Dobbyn, Lee, Widom, Louis, Lotta, Luca A., Mitnaul, Lyndon J., Pradhan, Manasi, Kapoor, Manav, Revez Ferreira, Manuel Allen, Jones, Marcus B., Sotiropoulos Padilla, Maria, Risman, Marjorie, Haas, Mary, Orelus, Max, Lattari, Michael, LeBlanc, Michelle G., Rana, Nadia, Lin, Nan, Banerjee, Nilanjana, Nishtala, Nirupama, Sosina, Olukayode, Akbari, Parsa, Nakka, Priyanka, Ulloa, Ricardo H., Judy, Renae, Lanche, Rouel, Malhotra, Sameer, Wolf, Sarah E., Damrauer, Scott, Dudek, Scott, O’Keeffe, Sean, Khalid, Shareef, Verma, Shefali S., Chen, Siying, Gokhale, Sujit, Balasubramanian, Suganthi, Bao, Suying, De, Tanima, Drivas, Theodore, Schleicher, Thomas D., Rajagopal, Veera, Salerno, William, Verma, Anurag, Morse Kripke, Colleen, Wollack, Colin, Sirugo, Giorgio, Weaver, JoEllen, Dunn, Joseph, Stephanowski, Julia, Nerz, Kyle P., Ritchie, Marylyn D., Naseer, Nawar, Haubein, Ned, Santos, Salma, DerOhannessian, Stephanie, Tran, Teo, Ko, Yi-An, Drivas, Theodore G.
Published in American journal of human genetics (07.08.2025)
Published in American journal of human genetics (07.08.2025)
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Journal Article
Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes
Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., Jorgenson, Eric
Published in Nature (London) (23.01.2025)
Published in Nature (London) (23.01.2025)
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Journal Article