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Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis
Porter, Richard Frederick, Szczesniak, Anna-Maria, Toguri, James Thomas, Gebremeskel, Simon, Johnston, Brent, Lehmann, Christian, Fingerle, Jürgen, Rothenhäusler, Benno, Perret, Camille, Rogers-Evans, Mark, Kimbara, Atsushi, Nettekoven, Matthias, Guba, Wolfgang, Grether, Uwe, Ullmer, Christoph, Kelly, Melanie E. M.
Published in Molecules (Basel, Switzerland) (13.09.2019)
Published in Molecules (Basel, Switzerland) (13.09.2019)
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Journal Article
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Grether, Uwe, Foxton, Richard H., Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E., Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M., Porter, Ross F., Toguri, Tom J., Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E. M., Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (2024)
Published in Frontiers in pharmacology (2024)
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Journal Article
Evaluation of a flow-photochemistry platform for the synthesis of compact modules
Nettekoven, Matthias, Püllmann, Bernd, Martin, Rainer E., Wechsler, David
Published in Tetrahedron letters (14.03.2012)
Published in Tetrahedron letters (14.03.2012)
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Journal Article
Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases
Nettekoven, Matthias, Adam, Jean-Michel, Bendels, Stefanie, Bissantz, Catarina, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Guba, Wolfgang, Kimbara, Atsushi, Ottaviani, Giorgio, Püllmann, Bernd, Rogers-Evans, Mark, Röver, Stephan, Rothenhäusler, Benno, Schmitt, Sebastien, Schuler, Franz, Schulz-Gasch, Tanja, Ullmer, Christoph
Published in ChemMedChem (19.01.2016)
Published in ChemMedChem (19.01.2016)
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Journal Article
6‑Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds
Röver, Stephan, Andjelkovic, Mirjana, Bénardeau, Agnès, Chaput, Evelyne, Guba, Wolfgang, Hebeisen, Paul, Mohr, Susanne, Nettekoven, Matthias, Obst, Ulrike, Richter, Wolfgang F, Ullmer, Christoph, Waldmeier, Pius, Wright, Matthew B
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Selective naphthalene H3 receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs
Rodríguez Sarmiento, Rosa María, Nettekoven, Matthias H., Taylor, Sven, Plancher, Jean-Marc, Richter, Hans, Roche, Olivier
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Highly potent and selective cannabinoid receptor 2 agonists: Initial hit optimization of an adamantyl hit series identified from high-through-put screening
Nettekoven, Matthias, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Kimbara, Atsushi, Püllmann, Bernd, Rogers-Evans, Mark, Röver, Stephan, Schuler, Franz, Schulz-Gasch, Tanja, Ullmer, Christoph
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
Identification of a Critical Residue in the Transmembrane Domain 2 of Tachykinin Neurokinin 3 Receptor Affecting the Dissociation Kinetics and Antagonism Mode of Osanetant (SR 142801) and Piperidine-Based Structures
Malherbe, Pari, Kratzeisen, Claudia, Marcuz, Anne, Zenner, Marie-Thérèse, Nettekoven, Matthias H, Ratni, Hasane, Wettstein, Joseph G, Bissantz, Caterina
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Journal Article
Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases
Werner Neidhart, Tanja Schulz-Gasch, Armin Ruf, Matthias Nettekoven, Hans Peter Märki, Bernd Kuhn, Daniel Hunziker, Aurelia Conte, Kurt Amrein, Jean Ackermann, Alexander V. Mayweg
Published in Chimia (01.01.2015)
Published in Chimia (01.01.2015)
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Journal Article
The Development of a Practical and Reliable Large-Scale Synthesis of 2,6-Diamino-4-bromopyridine
Nettekoven, Matthias, Jenny, Christian
Published in Organic process research & development (01.01.2003)
Published in Organic process research & development (01.01.2003)
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Journal Article
Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions
Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten
Published in Angewandte Chemie (01.10.2012)
Published in Angewandte Chemie (01.10.2012)
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Journal Article
NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS
Ouali Alami, Najwa, Schurr, Christine, Olde Heuvel, Florian, Tang, Linyun, Li, Qian, Tasdogan, Alpaslan, Kimbara, Atsushi, Nettekoven, Matthias, Ottaviani, Giorgio, Raposo, Catarina, Röver, Stephan, Rogers‐Evans, Mark, Rothenhäusler, Benno, Ullmer, Christoph, Fingerle, Jürgen, Grether, Uwe, Knuesel, Irene, Boeckers, Tobias M, Ludolph, Albert, Wirth, Thomas, Roselli, Francesco, Baumann, Bernd
Published in The EMBO journal (15.08.2018)
Published in The EMBO journal (15.08.2018)
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Journal Article
Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series
Pascale David Pierson, Christoph Ullmer, Sven Taylor, Tadakatsu Takahashi, Franz Schuler, Monique Schmitt, Rosa María Rodríguez Sarmiento, Olivier Roche, Hans Richter, Susanne Raab, Jean-Marc Plancher, Matthias Nettekoven, Toshito Nakagawa, Peter Mohr, Jörg Huwyler, Cornelia Hertel, Silvia Gatti-Mac Arthur, Christian Freichel, Ruby Wiegand
Published in Chimia (01.01.2009)
Published in Chimia (01.01.2009)
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Journal Article
Lead Generation: Sowing the Seeds for Future Success
Konrad H. Bleicher, Matthias Nettekoven, Jens-Uwe Peters, René Wyler
Published in Chimia (01.09.2004)
Published in Chimia (01.09.2004)
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Journal Article
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Korn, Claudia, Sykes, David, Forn-Cuni, Gabriel, Pfaff, Patrick, Sarott, Roman C, Westphal, Matthias V, Mostinski, Yelena, Mach, Leonard, Wasinska-Kalwa, Malgorzata, Weise, Marie, Hoare, Bradley L, Milju, Tamara, Mexi, Maira, Roth, Nicolas, Koers, Eline J, Guba, Wolfgang, Alker, Andr, Rufer, Arne C, Kusznir, Eric A, Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A, Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Nettekoven, Matthias, Benito-Cuesta, Irene, Grande, Teresa, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Honer, Michael, Fingerle, Jürgen, Scheffel, Jörg, Broichhagen, Johannes, Gawrisch, Klaus, Romero, Julián, Hillard, Cecilia J, Varga, Zoltan V, van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, Ullmer, Christoph, McCormick, Peter J, Oddi, Sergio, Spaink, Herman P, Maccarrone, Mauro, Veprintsev, Dmitry B, Carreira, Erick M, Grether, Uwe, Nazaré, Marc
Published in Chemical science (Cambridge) (18.05.2022)
Published in Chemical science (Cambridge) (18.05.2022)
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Journal Article
신경퇴행성 질환 치료용 스피로헵탄 유도체
FOLMER RUTGER, GRIFFIOEN JOHAN GERARD, VAN DER HEIJDEN GYDO, BERKENBOSCH TIM, CECERE GIUSEPPE, ROGER EVANS MARK, PRINCEN KATRIEN, BISSANTZ CATERINA, VOETS MARIEKE, RATNI HASANE, NETTEKOVEN MATTHIAS
Year of Publication 01.04.2025
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Year of Publication 01.04.2025
Patent
[45-d] NOVEL TRIAZOLO[45-D]PYRIMIDINE DERIVATIVES
KIMBARA ATSUSHI, ROGERS EVANS MARK, ROEVER STEPHAN, SCHMITT SEBASTIEN, GRETHER UWE, NETTEKOVEN MATTHIAS
Year of Publication 18.10.2022
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Year of Publication 18.10.2022
Patent
CB2 PURINE DERIVATIVES AS CB2 RECEPTOR AGONISTS
KIMBARA ATSUSHI, BENDELS STEFANIE, ROGERS EVANS MARK, ROEVER STEPHAN, SCHULZ GASCH TANJA, GRETHER UWE, NETTEKOVEN MATTHIAS
Year of Publication 01.12.2021
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Year of Publication 01.12.2021
Patent