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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., Abell, Chris
Published in Cell chemical biology (17.06.2021)
Published in Cell chemical biology (17.06.2021)
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Journal Article
An X-ray diffraction and X-ray absorption spectroscopy joint study of neuroglobin
Arcovito, Alessandro, Moschetti, Tommaso, D’Angelo, Paola, Mancini, Giordano, Vallone, Beatrice, Brunori, Maurizio, Della Longa, Stefano
Published in Archives of biochemistry and biophysics (01.07.2008)
Published in Archives of biochemistry and biophysics (01.07.2008)
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Journal Article
Two distinct conformational states define the interaction of human RAD51‐ATP with single‐stranded DNA
Brouwer, Ineke, Moschetti, Tommaso, Candelli, Andrea, Garcin, Edwige B, Modesti, Mauro, Pellegrini, Luca, Wuite, Gijs JL, Peterman, Erwin JG
Published in The EMBO journal (03.04.2018)
Published in The EMBO journal (03.04.2018)
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Journal Article
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents
Stockwell, Simon R., Scott, Duncan E., Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy P. C., Feng, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R., Blundell, Tom L., Spring, David R., McKenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R., Hyvönen, Marko
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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Journal Article
Development of a multipurpose scaffold for the display of peptide loops
Rossmann, Maxim, J. Greive, Sandra, Moschetti, Tommaso, Dinan, Michael, Hyvönen, Marko
Published in Protein engineering, design and selection (01.06.2017)
Published in Protein engineering, design and selection (01.06.2017)
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Journal Article
Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets
Gielen, Fabrice, Butz, Maren, Rees, Eric J, Erdelyi, Miklos, Moschetti, Tommaso, Hyvönen, Marko, Edel, Joshua B, Kaminski, Clemens F, Hollfelder, Florian
Published in Analytical chemistry (Washington) (17.01.2017)
Published in Analytical chemistry (Washington) (17.01.2017)
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Journal Article
Two distinct conformational states define the interaction of human RAD 51‐ ATP with single‐stranded DNA
Brouwer, Ineke, Moschetti, Tommaso, Candelli, Andrea, Garcin, Edwige B, Modesti, Mauro, Pellegrini, Luca, Wuite, Gijs JL, Peterman, Erwin JG
Published in The EMBO journal (03.04.2018)
Published in The EMBO journal (03.04.2018)
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Journal Article
Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51
Moschetti, Tommaso, Sharpe, Timothy, Fischer, Gerhard, Marsh, May E., Ng, Hong Kin, Morgan, Matthew, Scott, Duncan E., Blundell, Tom L., R. Venkitaraman, Ashok, Skidmore, John, Abell, Chris, Hyvönen, Marko
Published in Journal of molecular biology (20.11.2016)
Published in Journal of molecular biology (20.11.2016)
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Journal Article
3'-차단된 뉴클레오티드의 정제 및 중합
SCHNEIDER KIM, JACKSON AMANDA, PANCHAPAKESAN RAJAGOPAL, CHESNEY MICHAEL, MCCAULEY PATRICK, JACKSON ROSAMOND, RICHARDSON MARTA, DREWS BRADLEY, LAWRENCE ELLIOT, DAY HENRY, MASON STEPHEN, BETLEY JASON, MILLER OLIVER, SMITH DOMINIC, IMSAND ERIN, MOSCHETTI TOMMASO
Year of Publication 29.02.2024
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Year of Publication 29.02.2024
Patent
Neuroglobin: Enzymatic reduction and oxygen affinity
Giuffrè, Alessandro, Moschetti, Tommaso, Vallone, Beatrice, Brunori, Maurizio
Published in Biochemical and biophysical research communications (21.03.2008)
Published in Biochemical and biophysical research communications (21.03.2008)
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Journal Article
Failure of apoptosis-inducing factor to act as neuroglobin reductase
Moschetti, Tommaso, Giuffrè, Alessandro, Ardiccioni, Chiara, Vallone, Beatrice, Modjtahedi, Nazanine, Kroemer, Guido, Brunori, Maurizio
Published in Biochemical and biophysical research communications (04.12.2009)
Published in Biochemical and biophysical research communications (04.12.2009)
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Journal Article
CASCAT: The Power of The Combined Protein Engineering Approach: Evolution of A Glycine Oxidase for A Novel Mechanism of Glyphosate Tolerance
Loredano, Pollegioni, Mattia, Pedotti, Elena, Rosini, Gianluca, Molla, Tommaso, Moschetti
Published in Journal of biotechnology (01.11.2010)
Published in Journal of biotechnology (01.11.2010)
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Journal Article
PURIFYING AND POLYMERIZING 3'-BLOCKED NUCLEOTIDES
IMSAND, Erin, MCCAULEY, Patrick, MILLER, Oliver, LAWRENCE, Elliot, MOSCHETTI, Tommaso, JACKSON, Amanda, PANCHAPAKESAN, Rajagopal, CHESNEY, Michael, RICHARDSON, Marta, JACKSON, Rosamond, SMITH, Dominic, DAY, Henry, MASON, Stephen, DREWS, Bradley, SCHNEIDER, Kim, BETLEY, Jason
Year of Publication 10.04.2024
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Year of Publication 10.04.2024
Patent
PURIFYING AND POLYMERIZING 3'-BLOCKED NUCLEOTIDES
IMSAND, Erin, MCCAULEY, Patrick, MILLER, Oliver, LAWRENCE, Elliot, MOSCHETTI, Tommaso, JACKSON, Amanda, PANCHAPAKESAN, Rajagopal, CHESNEY, Michael, RICHARDSON, Marta, JACKSON, Rosamond, SMITH, Dominic, DAY, Henry, MASON, Stephen, DREWS, Bradley, SCHNEIDER, Kim, BETLEY, Jason
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
Patent
Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents
Stockwell, Simon R, Scott, Duncan E, Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy P C, Fang, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R, Blundell, Tom L, Spring, David R, Mckenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R, Hyvönen, Marko
Published in bioRxiv (04.02.2024)
Published in bioRxiv (04.02.2024)
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Paper
Selective Aurora A-TPX2 interaction inhibitors have in vivo efficacy as targeted anti-mitotic agents
Stockwell, Simon R., Scott, Duncan E., Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy P. C., Feng, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R., Blundell, Tom L., Spring, David R., McKenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R., Hyvönen, Marko
Published in bioRxiv (04.02.2024)
Published in bioRxiv (04.02.2024)
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Paper
PURIFYING AND POLYMERIZING 3'-BLOCKED NUCLEOTIDES
Richardson, Marta, Jackson, Amanda, Drews, Bradley, Moschetti, Tommaso, Schneider, Kim, Betley, Jason, Miller, Oliver, Chesney, Michael, Day, Henry, McCauley, Patrick, Mason, Stephen, Jackson, Rosamond, Panchapakesan, Rajagopal, Imsand, Erin, Lawrence, Elliot, Smith, Dominic
Year of Publication 08.12.2022
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Year of Publication 08.12.2022
Patent
PURIFYING AND POLYMERIZING 3'-BLOCKED NUCLEOTIDES
IMSAND, Erin, MCCAULEY, Patrick, MILLER, Oliver, LAWRENCE, Elliot, MOSCHETTI, Tommaso, JACKSON, Amanda, PANCHAPAKESAN, Rajagopal, CHESNEY, Michael, RICHARDSON, Marta, JACKSON, Rosamond, SMITH, Dominic, DAY, Henry, MASON, Stephen, DREWS, Bradley, SCHNEIDER, Kim, BETLEY, Jason
Year of Publication 01.12.2022
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Year of Publication 01.12.2022
Patent