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ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics
Nilsson, Boel, Bylund, Johan, Halldin, Magnus M., Rother, Matthias, Rein-Hedin, Erik, Önnestam, Kristin, Segerdahl, Märta
Published in European journal of clinical pharmacology (01.05.2024)
Published in European journal of clinical pharmacology (01.05.2024)
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Journal Article
Safety, pharmacokinetics and quantitative EEG modulation of TAK‐071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects
Yin, Wei, Mamashli, Fahimeh, Buhl, Derek L., Khudyakov, Polyna, Volfson, Dmitri, Martenyi, Ferenc, Gevorkyan, Hakop, Rosen, Laura, Simen, Arthur A.
Published in British journal of clinical pharmacology (01.02.2022)
Published in British journal of clinical pharmacology (01.02.2022)
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Journal Article
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer’s Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial
Hua, Xue, Church, Kevin, Walker, William, L’Hostis, Philippe, Viardot, Geoffrey, Danjou, Philippe, Hendrix, Suzanne, Moebius, Hans J.
Published in Journal of Alzheimer's disease (2022)
Published in Journal of Alzheimer's disease (2022)
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Journal Article
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Toyn, Jeremy H., Boy, Kenneth M., Raybon, Joseph, Meredith, Jere E., Robertson, Alan S., Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R. Rex, Zuev, Dmitry, Thompson, Lorin A., Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A., Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Gasior, Maciej, Olson, Richard E., Hong, Quan, Soares, Holly D., AbuTarif, Malaz, Ahlijanian, Michael K.
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Journal Article
Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects
Ali, Zahid, Laurijssens, Bart, Ostenfeld, Thor, McHugh, Simon, Stylianou, Anastasia, Scott‐Stevens, Paul, Hosking, Louise, Dewit, Odile, Richardson, Jill C., Chen, Chao
Published in British journal of clinical pharmacology (01.01.2013)
Published in British journal of clinical pharmacology (01.01.2013)
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Journal Article
Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial
Rebello, Candida J., Burton, Jeffrey, Heiman, Mark, Greenway, Frank L.
Published in Journal of diabetes and its complications (01.11.2015)
Published in Journal of diabetes and its complications (01.11.2015)
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Journal Article
The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects
Cavallone, Laura F., Montana, Michael C., Frey, Karen, Kallogjeri, Dorina, Wages, James M., Rodebaugh, Thomas L., Doshi, Tina, Kharasch, Evan D., Gereau, Robert W.
Published in Pain (Amsterdam) (01.01.2020)
Published in Pain (Amsterdam) (01.01.2020)
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Journal Article
Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects
Juif, Pierre-Eric, Baldoni, Daniela, Reyes, Maribel, Wilbraham, Darren, Febbraro, Salvatore, Vaclavkova, Andrea, Hoch, Matthias, Dingemanse, Jasper
Published in International journal of molecular sciences (06.12.2017)
Published in International journal of molecular sciences (06.12.2017)
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Journal Article
Safety, pharmacokinetics, and antiviral activity of the class II capsid assembly modulator ALG-000184 in subjects with chronic hepatitis B
Yuen, Man-Fung, Agarwal, Kosh, Gane, Edward J, Jucov, Alina, Schwabe, Christian, Niu, Junqi, Hou, Jinlin, Le, Kha, Massetto, Benedetta, Westland, Christopher, Zhang, Qingling, Lai, Felix, Venkatraman, Meenakshi, Blatt, Lawrence, Lin, Tse-I, Chanda, Sushmita, McClure, Matt, Fry, John
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
SAT365 - Safety, pharmacokinetics, and antiviral activity of the class II capsid assembly modulator ALG-000184 in subjects with chronic hepatitis B
Yuen, Man-Fung, Agarwal, Kosh, Gane, Edward J, Jucov, Alina, Schwabe, Christian, Niu, Junqi, Hou, Jinlin, Le, Kha, Massetto, Benedetta, Westland, Christopher, Zhang, Qingling, Lai, Felix, Venkatraman, Meenakshi, Blatt, Lawrence, Lin, Tse-I, Chanda, Sushmita, McClure, Matt, Fry, John
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Wilbraham, Darren, Biglan, Kevin M., Svensson, Kjell A., Tsai, Max, Kielbasa, William
Published in Clinical pharmacology in drug development (01.04.2021)
Published in Clinical pharmacology in drug development (01.04.2021)
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Journal Article
THU-242 Viral kinetics and sequence analysis of a phase I monotherapy study in subjects with chronic hepatitis B reveals a high barrier of resistance to the capsid assembly modulator ALG-000184
Jekle, Andreas, Jackson, Kathy, O’Keefe, Jacinta, Edwards, Ros, Yuen, Lilly, Chibo, Doris, Van, Thanh, Rito, Jen, Maderazo, Maida, Symons, Julian, Blatt, Lawrence, Viani, Rolando, Achneck, Hardean, Lin, Tse-I, Wu, Min
Published in Journal of hepatology (01.05.2025)
Published in Journal of hepatology (01.05.2025)
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Journal Article
THU-261 Monotherapy with the novel capsid assembly modulator ALG- 000184 for up to 96 weeks results in profound and sustained HBV DNA suppression in untreated subjects with chronic HBV infection
Yuen, Man-Fung, Agarwal, Kosh, Jucov, Alina, Haceatrean, Alexei, Wu, Min, Le, Kha, Van, Thanh, Rito, Jen, Blatt, Lawrence, Chanda, Sushmita, Lin, Tse-I, Achneck, Hardean, Gane, Edward J.
Published in Journal of hepatology (01.05.2025)
Published in Journal of hepatology (01.05.2025)
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Journal Article
SAT-192 - Treatment for up to 24 weeks with the capsid assembly modulator ALG-000184 results in dose related reductions in HBsAg in subjects with HBeAg positive chronic hepatitis B
Hou, Jinlin, Ding, Yanhua, Niu, Junqi, Liang, Xieer, Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Massetto, Benedetta, Wu, Min, Le, Kha, Venkatraman, Meenakshi, Zhang, Qingling, Westland, Christopher, Maderazo, Maida, Chanda, Sushmita, Beigelman, Leonid, Blatt, Lawrence, Lin, Tse-I, McClure, Matt, Fry, John
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Treatment for up to 24 weeks with the capsid assembly modulator ALG-000184 results in dose related reductions in HBsAg in subjects with HBeAg positive chronic hepatitis B
Hou, Jinlin, Ding, Yanhua, Niu, Junqi, Liang, Xieer, Yuen, Man-Fung, Gane, Edward J., Agarwal, Kosh, Massetto, Benedetta, Wu, Min, Le, Kha, Venkatraman, Meenakshi, Zhang, Qingling, Westland, Christopher, Maderazo, Maida, Chanda, Sushmita, Beigelman, Leonid, Blatt, Lawrence, Lin, Tse-I, McClure, Matt, Fry, John
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Cystic Fibrosis Transmembrane Conductance Regulator Modulator Use is Associated with Reduced Pancreatitis Hospitalizations in Subjects with Cystic Fibrosis
Ramsey, Mitchell L, Gokun, Yevgeniya, Sobotka, Lindsay A, Wellner, Michael R, Porter, Kyle, Kirkby, Stephen E, Li, Susan S, Papachristou, Georgios I, Krishna, Somashekar G, Stanich, Peter P, Hart, Phil A, Conwell, Darwin L, Lara, Luis F
Published in The American journal of gastroenterology (01.12.2021)
Published in The American journal of gastroenterology (01.12.2021)
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Journal Article
First‐in‐Human, Single‐ and Multiple‐Ascending‐Dose Studies in Healthy Subjects to Assess Pharmacokinetics, Pharmacodynamics, and Safety/Tolerability of Iberdomide, a Novel Cereblon E3 Ligase Modulator
Ye, Ying, Gaudy, Allison, Schafer, Peter, Thomas, Michael, Weiss, Daniel, Chen, Nianhang, Liu, Liangang, Xue, Yongjun, Carayannopoulos, Leon, Palmisano, Maria
Published in Clinical pharmacology in drug development (01.05.2021)
Published in Clinical pharmacology in drug development (01.05.2021)
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Journal Article
Drug‐Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC‐122) in Healthy Adult Subjects
Ogasawara, Ken, MacGorman, Kimberly, Liu, Liangang, Chen, Jian, Carayannopoulos, Leonidas N., Zhou, Simon, Palmisano, Maria, Li, Yan
Published in Journal of clinical pharmacology (01.12.2019)
Published in Journal of clinical pharmacology (01.12.2019)
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Journal Article
Volition as a modulator of the intergroup empathy bias
Caspar, Emilie A., Nicolay, Eva, Banderembaho, Félix, Pech, Guillaume P.
Published in Social neuroscience (01.11.2024)
Published in Social neuroscience (01.11.2024)
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Journal Article