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Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Jiang, Lei, Shestov, Alexander A., Swain, Pamela, Yang, Chendong, Parker, Seth J., Wang, Qiong A., Terada, Lance S., Adams, Nicholas D., McCabe, Michael T., Pietrak, Beth, Schmidt, Stan, Metallo, Christian M., Dranka, Brian P., Schwartz, Benjamin, DeBerardinis, Ralph J.
Published in Nature (London) (14.04.2016)
Published in Nature (London) (14.04.2016)
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Journal Article
An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D., Dawson, Mark A.
Published in Cancer cell (14.10.2019)
Published in Cancer cell (14.10.2019)
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Journal Article
Dnmt1 has de novo activity targeted to transposable elements
Haggerty, Chuck, Kretzmer, Helene, Riemenschneider, Christina, Kumar, Abhishek Sampath, Mattei, Alexandra L., Bailly, Nina, Gottfreund, Judith, Giesselmann, Pay, Weigert, Raha, Brändl, Björn, Giehr, Pascal, Buschow, René, Galonska, Christina, von Meyenn, Ferdinand, Pappalardi, Melissa B., McCabe, Michael T., Wittler, Lars, Giesecke-Thiel, Claudia, Mielke, Thorsten, Meierhofer, David, Timmermann, Bernd, Müller, Franz-Josef, Walter, Jörn, Meissner, Alexander
Published in Nature structural & molecular biology (01.07.2021)
Published in Nature structural & molecular biology (01.07.2021)
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Journal Article
Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications
McCabe, Michael T., Brandes, Johann C., Vertino, Paula M.
Published in Clinical cancer research (15.06.2009)
Published in Clinical cancer research (15.06.2009)
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Journal Article
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Béguelin, Wendy, Popovic, Relja, Teater, Matt, Jiang, Yanwen, Bunting, Karen L., Rosen, Monica, Shen, Hao, Yang, Shao Ning, Wang, Ling, Ezponda, Teresa, Martinez-Garcia, Eva, Zhang, Haikuo, Zheng, Yupeng, Verma, Sharad K., McCabe, Michael T., Ott, Heidi M., Van Aller, Glenn S., Kruger, Ryan G., Liu, Yan, McHugh, Charles F., Scott, David W., Chung, Young Rock, Kelleher, Neil, Shaknovich, Rita, Creasy, Caretha L., Gascoyne, Randy D., Wong, Kwok-Kin, Cerchietti, Leandro, Levine, Ross L., Abdel-Wahab, Omar, Licht, Jonathan D., Elemento, Olivier, Melnick, Ari M.
Published in Cancer cell (13.05.2013)
Published in Cancer cell (13.05.2013)
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Journal Article
Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons
Iskow, Rebecca C., McCabe, Michael T., Mills, Ryan E., Torene, Spencer, Pittard, W. Stephen, Neuwald, Andrew F., Van Meir, Erwin G., Vertino, Paula M., Devine, Scott E.
Published in Cell (25.06.2010)
Published in Cell (25.06.2010)
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Journal Article
BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models
Wyce, Anastasia, Ganji, Gopinath, Smitheman, Kimberly N., Chung, Chun-wa, Korenchuk, Susan, Bai, Yuchen, Barbash, Olena, Le, BaoChau, Craggs, Peter D., McCabe, Michael T., Kennedy-Wilson, Karen M., Sanchez, Lydia V., Gosmini, Romain L., Parr, Nigel, McHugh, Charles F., Dhanak, Dashyant, Prinjha, Rab K., Auger, Kurt R., Tummino, Peter J.
Published in PloS one (23.08.2013)
Published in PloS one (23.08.2013)
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Journal Article
Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein of the testis carcinoma and other cancers: Results of a Phase I/II open‐label, dose escalation study
Cousin, Sophie, Blay, Jean‐Yves, Garcia, Irene Braña, Bono, Johann S., Le Tourneau, Christophe, Moreno, Victor, Trigo, Jose, Hann, Christine L., Azad, Arun A., Im, Seock‐Ah, Cassier, Philippe A., French, Christopher A., Italiano, Antoine, Keedy, Vicki L., Plummer, Ruth, Sablin, Marie‐Paule, Hemming, Matthew L., Ferron‐Brady, Geraldine, Wyce, Anastasia, Khaled, Ahmed, Datta, Antara, Foley, Shawn W., McCabe, Michael T., Wu, Yuehui, Horner, Thierry, Kremer, Brandon E., Dhar, Arindam, O'Dwyer, Peter J., Shapiro, Geoffrey I., Piha‐Paul, Sarina A.
Published in International journal of cancer (15.03.2022)
Published in International journal of cancer (15.03.2022)
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Journal Article
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
McCabe, Michael T, Graves, Alan P, Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S, Jiang, Yong, Smitheman, Kimberly N, Ott, Heidi M, Pappalardi, Melissa B, Allen, Kimberly E, Chen, Stephanie B, Della Pietra, Anthony III, Dul, Edward, Hughes, Ashley M, Gilbert, Seth A, Thrall, Sara H, Tummino, Peter J, Kruger, Ryan G, Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Journal Article
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
Gilmartin, Aidan G, Groy, Arthur, Gore, Elizabeth R, Atkins, Charity, Long, Edward R, Montoute, Monica N, Wu, Zining, Halsey, Wendy, McNulty, Dean E, Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa, Kruger, Ryan G, McCabe, Michael T, Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B
Published in Haematologica (Roma) (01.07.2021)
Published in Haematologica (Roma) (01.07.2021)
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Journal Article
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all- trans retinoic acid in acute myeloid leukemia across subtypes
Smitheman, Kimberly N., Severson, Tesa M., Rajapurkar, Satyajit R., McCabe, Michael T., Karpinich, Natalie, Foley, James, Pappalardi, Melissa B., Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E., Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K., Carpenter, Christopher L., Kruger, Ryan G., Wessels, Lodewyk, Mohammad, Helai P.
Published in Haematologica (Roma) (01.06.2019)
Published in Haematologica (Roma) (01.06.2019)
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Journal Article
A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation
Ge, Alex Y., Arab, Abolfazl, Dai, Raymond, Navickas, Albertas, Fish, Lisa, Garcia, Kristle, Asgharian, Hosseinali, Goudreau, Jackson, Lee, Sean, Keenan, Kathryn, Pappalardi, Melissa B., McCabe, Michael T., Przybyla, Laralynne, Goodarzi, Hani, Gilbert, Luke A.
Published in Scientific reports (29.10.2024)
Published in Scientific reports (29.10.2024)
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Journal Article
PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Patel, Amish J., Warda, Sarah, Maag, Jesper L.V., Misra, Rohan, Miranda-Román, Miguel A., Pachai, Mohini R., Lee, Cindy J., Li, Dan, Wang, Naitao, Bayshtok, Gabriella, Fishinevich, Eve, Meng, Yinuo, Wong, Elissa W.P., Yan, Juan, Giff, Emily, Pappalardi, Melissa B., McCabe, Michael T., Fletcher, Jonathan A., Rudin, Charles M., Chandarlapaty, Sarat, Scandura, Joseph M., Koche, Richard P., Glass, Jacob L., Antonescu, Cristina R., Zheng, Deyou, Chen, Yu, Chi, Ping
Published in Cancer discovery (02.09.2022)
Published in Cancer discovery (02.09.2022)
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Journal Article
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
Verma, Sharad K, Tian, Xinrong, LaFrance, Louis V, Duquenne, Céline, Suarez, Dominic P, Newlander, Kenneth A, Romeril, Stuart P, Burgess, Joelle L, Grant, Seth W, Brackley, James A, Graves, Alan P, Scherzer, Daryl A, Shu, Art, Thompson, Christine, Ott, Heidi M, Aller, Glenn S. Van, Machutta, Carl A, Diaz, Elsie, Jiang, Yong, Johnson, Neil W, Knight, Steven D, Kruger, Ryan G, McCabe, Michael T, Dhanak, Dashyant, Tummino, Peter J, Creasy, Caretha L, Miller, William H
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Journal Article
Momelotinib: Mechanism of action, clinical, and translational science
Vlasakakis, Georgios, McCabe, Michael T., Ho, Yu Liu, Ferron‐Brady, Geraldine, Martin, Paul, Bentley, Darren, Ellis, Catherine, Antonysamy, Mary, Visser, Sandra A. G.
Published in Clinical and translational science (01.08.2024)
Published in Clinical and translational science (01.08.2024)
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Journal Article
A687V EZH2 Is a Driver of Histone H3 Lysine 27 (H3K27) Hypertrimethylation
Ott, Heidi M., Graves, Alan P., Pappalardi, Melissa B., Huddleston, Michael, Halsey, Wendy S., Hughes, Ashley M., Groy, Arthur, Dul, Edward, Jiang, Yong, Bai, Yuchen, Annan, Roland, Verma, Sharad K., Knight, Steven D., Kruger, Ryan G., Dhanak, Dashyant, Schwartz, Benjamin, Tummino, Peter J., Creasy, Caretha L., McCabe, Michael T.
Published in Molecular cancer therapeutics (01.12.2014)
Published in Molecular cancer therapeutics (01.12.2014)
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Journal Article
Regulation of DNA Methyltransferase 1 by the pRb/E2F1 Pathway
McCabe, Michael T., Davis, Joanne N., Day, Mark L.
Published in Cancer research (Chicago, Ill.) (01.05.2005)
Published in Cancer research (Chicago, Ill.) (01.05.2005)
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Journal Article
Long Residence Time Inhibition of EZH2 in Activated Polycomb Repressive Complex 2
Van Aller, Glenn S, Pappalardi, Melissa Baker, Ott, Heidi M, Diaz, Elsie, Brandt, Martin, Schwartz, Benjamin J, Miller, William H, Dhanak, Dashyant, McCabe, Michael T, Verma, Sharad K, Creasy, Caretha L, Tummino, Peter J, Kruger, Ryan G
Published in ACS chemical biology (21.03.2014)
Published in ACS chemical biology (21.03.2014)
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Journal Article
Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
Wiseman, Ashley K., Tiedemann, Rochelle L., Fan, Huihui, Shen, Hui, Madaj, Zachary, McCabe, Michael T., Pappalardi, Melissa B., Jones, Peter A.
Published in Communications biology (02.06.2022)
Published in Communications biology (02.06.2022)
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Journal Article