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Evolution of preclinical characterization and insights into clinical pharmacology of checkpoint inhibitors approved for cancer immunotherapy
Kasichayanula, Sreeneeranj, Mandlekar, Sandhya, Shivva, Vittal, Patel, Maulik, Girish, Sandhya
Published in Clinical and translational science (01.08.2022)
Published in Clinical and translational science (01.08.2022)
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Journal Article
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
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Journal Article
Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
Zhang, Yueping, Han, Yong-Hae, Putluru, Siva Prasad, Matta, Murali Krishna, Kole, Prashant, Mandlekar, Sandhya, Furlong, Michael T, Liu, Tongtong, Iyer, Ramaswamy A, Marathe, Punit, Yang, Zheng, Lai, Yurong, Rodrigues, A. David
Published in Drug metabolism and disposition (01.03.2016)
Published in Drug metabolism and disposition (01.03.2016)
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Journal Article
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development
Tomlinson, Lindsay, Ramsden, Diane, Leite, Sofia Batista, Beken, Sonja, Bonzo, Jessica A., Brown, Paul, Candarlioglu, Pelin L., Chan, Tom S., Chen, Eugene, Choi, Colin K., David, Rhiannon, Delrue, Nathalie, Devine, Patrick J., Ford, Kevin, Garcia, Martha Iveth, Gosset, James R., Hewitt, Philip, Homan, Kimberly, Irrechukwu, Onyi, Kopec, Anna K., Liras, Jennifer L., Mandlekar, Sandhya, Raczynski, Arek, Sadrieh, Nakissa, Sakatis, Melanie Z., Siegel, Jeffrey, Sung, Kyung, Sunyovszki, Ilona, Van Vleet, Terry R., Ekert, Jason E., Hardwick, Rhiannon N.
Published in Advanced biology (01.08.2024)
Published in Advanced biology (01.08.2024)
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Journal Article
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models
Holenarsipur, Vinay K., Gaud, Nilesh, Sinha, Jaydeep, Sivaprasad, Sankara, Bhutani, Priyadeep, Subramanian, Murali, Singh, Sheelendra Pratap, Arla, Rambabu, Paruchury, Sundeep, Sharma, Tarun, Marathe, Punit, Mandlekar, Sandhya
Published in Biopharmaceutics & drug disposition (01.09.2015)
Published in Biopharmaceutics & drug disposition (01.09.2015)
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Journal Article
Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals
Yu, Rong, Lei, Wei, Mandlekar, Sandhya, Weber, Michael J., Der, Channing J., Wu, Jie, Kong, A.-N. Tony
Published in The Journal of biological chemistry (24.09.1999)
Published in The Journal of biological chemistry (24.09.1999)
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Journal Article
Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System
Selvakumar, Sindhuja, Bhutani, Priyadeep, Ghosh, Kaushik, Krishnamurthy, Prasad, Kallipatti, Sanjith, Selvam, Sabariya, Ramarao, Manjunath, Mandlekar, Sandhya, Sinz, Michael W, Rodrigues, A. David, Subramanian, Murali
Published in Drug metabolism and disposition (01.03.2014)
Published in Drug metabolism and disposition (01.03.2014)
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Journal Article
Estimation of the Unbound Brain Concentration of P‑Glycoprotein Substrates or Nonsubstrates by a Serial Cerebrospinal Fluid Sampling Technique in Rats
Mariappan, T. Thanga, Kurawattimath, Vishwanath, Gautam, Shashyendra Singh, Kulkarni, Chetan P, Kallem, Rajareddy, Taskar, Kunal S, Marathe, Punit H, Mandlekar, Sandhya
Published in Molecular pharmaceutics (03.02.2014)
Published in Molecular pharmaceutics (03.02.2014)
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Journal Article
p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens
Yu, Rong, Mandlekar, Sandhya, Lei, Wei, Fahl, William E., Tan, Tse-Hua, Kong, A.-N.Tony
Published in The Journal of biological chemistry (28.01.2000)
Published in The Journal of biological chemistry (28.01.2000)
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Journal Article
Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
Kong, Ah-Ng Tony, Yu, Rong, Chen, Chi, Mandlekar, Sandhya, Primiano, Thomas
Published in Archives of pharmacal research (01.02.2000)
Published in Archives of pharmacal research (01.02.2000)
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Journal Article
Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat
Taskar, Kunal S, Mariappan, T Thanga, Kurawattimath, Vishwanath, Singh Gautam, Shashyendra, Radhakrishna Mullapudi, TV, Sridhar, Srikanth K, Kallem, Raja Reddy, Marathe, Punit, Mandlekar, Sandhya
Published in Journal of central nervous system disease (01.01.2017)
Published in Journal of central nervous system disease (01.01.2017)
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Journal Article
Resveratrol Inhibits Phorbol Ester and UV-Induced Activator Protein 1 Activation by Interfering with Mitogen-Activated Protein Kinase Pathways
Yu, Rong, Hebbar, Vidya, Kim, Daniel W., Mandlekar, Sandhya, Pezzuto, John M., Kong, Ah-Ng Tony
Published in Molecular pharmacology (01.07.2001)
Published in Molecular pharmacology (01.07.2001)
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Journal Article
Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists
Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Nelson, David J, Lo, Yvonne C, Yang, Gengjie, Scherle, Peggy A, Mandlekar, Sandhya, Wasserman, Zelda R, Jezak, Heather, Solomon, Kimberly A, Tebben, Andrew J, Carter, Percy H, Decicco, Carl P
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation
Das, Anuk M., Vaddi, Krishna G., Solomon, Kimberly A., Krauthauser, Candice, Jiang, Xiaosui, McIntyre, Kim W., Yang, Xiao Xia, Wadman, Eric, Welch, Patricia, Covington, Maryanne, Graden, Danielle, Yeleswaram, Krishnaswamy, Trzaskos, James M., Newton, Robert C., Mandlekar, Sandhya, Ko, Soo S., Carter, Percy H., Davies, Paul
Published in The Journal of pharmacology and experimental therapeutics (01.07.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2006)
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Journal Article
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
Shtil, Alexander A, Mandlekar, Sandhya, Yu, Rong, Walter, Robert J, Hagen, Karen, Tan, Tse-Hua, Roninson, Igor B, Kong, Ah-Ng Tony
Published in Oncogene (14.01.1999)
Published in Oncogene (14.01.1999)
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Journal Article
A Comparative Clinical Pharmacology Analysis of FDA‐Approved Targeted Covalent Inhibitors vs. Reversible Inhibitors in Oncology
Ngo, Huy X., Wen, Yue Winnie, Pisupati, Swathi, Huang, Weize, Mandlekar, Sandhya
Published in Clinical pharmacology and therapeutics (01.11.2024)
Published in Clinical pharmacology and therapeutics (01.11.2024)
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Journal Article
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation
Sacher, Adrian, LoRusso, Patricia, Patel, Manish R., Miller, Wilson H., Garralda, Elena, Forster, Martin D., Santoro, Armando, Falcon, Alejandro, Kim, Tae Won, Paz-Ares, Luis, Bowyer, Samantha, de Miguel, Maria, Han, Sae-Won, Krebs, Matthew G., Lee, Jong-Seok, Cheng, Michael L., Arbour, Kathryn, Massarelli, Erminia, Choi, Yoonha, Shi, Zhen, Mandlekar, Sandhya, Lin, Mark T., Royer-Joo, Stephanie, Chang, Julie, Dharia, Neekesh V., Schutzman, Jennifer L., Desai, Jayesh
Published in The New England journal of medicine (24.08.2023)
Published in The New England journal of medicine (24.08.2023)
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Journal Article
Web Resource
Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition
Lai, Yurong, Mandlekar, Sandhya, Shen, Hong, Holenarsipur, Vinay K., Langish, Robert, Rajanna, Prabhakar, Murugesan, Senthilkumar, Gaud, Nilesh, Selvam, Sabariya, Date, Onkar, Cheng, Yaofeng, Shipkova, Petia, Dai, Jun, Humphreys, William G., Marathe, Punit
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
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Journal Article