Vyzkoušejte nový nástroj s podporou AI
Summon Research Assistant
BETA
Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C‑12b Hydroxylation and Substrate Inhibition in PgaE
Kallio, Pauli, Patrikainen, Pekka, Belogurov, Georgiy A, Mäntsälä, Pekka, Yang, Keqian, Niemi, Jarmo, Metsä-Ketelä, Mikko
Published in Biochemistry (Easton) (02.07.2013)
Published in Biochemistry (Easton) (02.07.2013)
Get full text
Journal Article
Structural and Functional Analysis of Angucycline C‑6 Ketoreductase LanV Involved in Landomycin Biosynthesis
Paananen, Pasi, Patrikainen, Pekka, Kallio, Pauli, Mäntsälä, Pekka, Niemi, Jarmo, Niiranen, Laila, Metsä-Ketelä, Mikko
Published in Biochemistry (Easton) (06.08.2013)
Published in Biochemistry (Easton) (06.08.2013)
Get full text
Journal Article
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway
Oja, Terhi, Niiranen, Laila, Sandalova, Tatyana, Klika, Karel D., Niemi, Jarmo, Mäntsälä, Pekka, Schneider, Gunter, Metsä-Ketelä, Mikko
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2013)
Get full text
Journal Article
Molecular Evolution of Aromatic Polyketides and Comparative Sequence Analysis of Polyketide Ketosynthase and 16S Ribosomal DNA Genes from Various Streptomyces Species
Metsä-Ketelä, Mikko, Halo, Laura, Munukka, Eveliina, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina
Published in Applied and Environmental Microbiology (01.09.2002)
Published in Applied and Environmental Microbiology (01.09.2002)
Get full text
Journal Article
Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis
Lindqvist, Ylva, Koskiniemi, Hanna, Jansson, Anna, Sandalova, Tatyana, Schnell, Robert, Liu, Zhanliang, Mäntsälä, Pekka, Niemi, Jarmo, Schneider, Gunter
Published in Journal of molecular biology (06.11.2009)
Published in Journal of molecular biology (06.11.2009)
Get full text
Journal Article
Crystal Structures of Two Aromatic Hydroxylases Involved in the Early Tailoring Steps of Angucycline Biosynthesis
Koskiniemi, Hanna, Metsä-Ketelä, Mikko, Dobritzsch, Doreen, Kallio, Pauli, Korhonen, Hanna, Mäntsälä, Pekka, Schneider, Gunter, Niemi, Jarmo
Published in Journal of molecular biology (21.09.2007)
Published in Journal of molecular biology (21.09.2007)
Get full text
Journal Article
Engineering Anthracycline Biosynthesis toward Angucyclines
Metsä-Ketelä, Mikko, Palmu, Kaisa, Kunnari, Tero, Ylihonko, Kristiina, Mäntsälä, Pekka
Published in Antimicrobial Agents and Chemotherapy (01.04.2003)
Published in Antimicrobial Agents and Chemotherapy (01.04.2003)
Get full text
Journal Article
Crystal Structures of SnoaL2 and AclR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide Antibiotics
Beinker, Philipp, Lohkamp, Bernhard, Peltonen, Taina, Niemi, Jarmo, Mäntsälä, Pekka, Schneider, Gunter
Published in Journal of molecular biology (09.06.2006)
Published in Journal of molecular biology (09.06.2006)
Get full text
Journal Article
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster
Räty, Kaj, Kantola, Jaana, Hautala, Anne, Hakala, Juha, Ylihonko, Kristiina, Mäntsälä, Pekka
Published in Gene (26.06.2002)
Published in Gene (26.06.2002)
Get full text
Journal Article
Flavoprotein Hydroxylase PgaE Catalyzes Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis
Kallio, Pauli, Patrikainen, Pekka, Suomela, Jukka-Pekka, Mäntsälä, Pekka, Metsä-Ketelä, Mikko, Niemi, Jarmo
Published in Biochemistry (Easton) (21.06.2011)
Published in Biochemistry (Easton) (21.06.2011)
Get full text
Journal Article
Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage
Oja, Terhi, Klika, Karel D, Appassamy, Laura, Sinkkonen, Jari, Mäntsälä, Pekka, Niemi, Jarmo, Metsä-Ketelä, Mikko
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2012)
Get full text
Journal Article
Crystal Structure of the Cofactor-Independent Monooxygenase SnoaB from Streptomyces nogalater: Implications for the Reaction Mechanism
Grocholski, Thadee, Koskiniemi, Hanna, Lindqvist, Ylva, Mäntsälä, Pekka, Niemi, Jarmo, Schneider, Gunter
Published in Biochemistry (Easton) (09.02.2010)
Published in Biochemistry (Easton) (09.02.2010)
Get full text
Journal Article
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site
Alexeev, Igor, Sultana, Azmiri, Mäntsälä, Pekka, Niemi, Jarmo, Schneider, Gunter
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2007)
Get full text
Journal Article
Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin
Siitonen, Vilja, Claesson, Magnus, Patrikainen, Pekka, Aromaa, Maria, Mäntsälä, Pekka, Schneider, Gunter, Metsä-Ketelä, Mikko
Published in Chembiochem : a European journal of chemical biology (02.01.2012)
Published in Chembiochem : a European journal of chemical biology (02.01.2012)
Get full text
Journal Article
Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis
Sultana, Azmiri, Kallio, Pauli, Jansson, Anna, Niemi, Jarmo, Mäntsälä, Pekka, Schneider, Gunter
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2004)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2004)
Get full text
Journal Article