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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Lotta, Luca A., Scott, Robert A., Sharp, Stephen J., Burgess, Stephen, Luan, Jian’an, Tillin, Therese, Schmidt, Amand F., Imamura, Fumiaki, Stewart, Isobel D., Perry, John R. B., Marney, Luke, Koulman, Albert, Karoly, Edward D., Forouhi, Nita G., Sjögren, Rasmus J. O., Näslund, Erik, Zierath, Juleen R., Krook, Anna, Savage, David B., Griffin, Julian L., Chaturvedi, Nishi, Hingorani, Aroon D., Khaw, Kay-Tee, Barroso, Inês, McCarthy, Mark I., O’Rahilly, Stephen, Wareham, Nicholas J., Langenberg, Claudia
Published in PLoS medicine (29.11.2016)
Published in PLoS medicine (29.11.2016)
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Journal Article
Exome sequencing and analysis of 454,787 UK Biobank participants
Backman, Joshua D., Li, Alexander H., Marcketta, Anthony, Sun, Dylan, Mbatchou, Joelle, Kessler, Michael D., Benner, Christian, Liu, Daren, Locke, Adam E., Balasubramanian, Suganthi, Yadav, Ashish, Banerjee, Nilanjana, Gillies, Christopher E., Damask, Amy, Liu, Simon, Bai, Xiaodong, Hawes, Alicia, Maxwell, Evan, Gurski, Lauren, Watanabe, Kyoko, Kosmicki, Jack A., Rajagopal, Veera, Mighty, Jason, Jones, Marcus, Mitnaul, Lyndon, Stahl, Eli, Coppola, Giovanni, Jorgenson, Eric, Habegger, Lukas, Salerno, William J., Shuldiner, Alan R., Lotta, Luca A., Overton, John D., Cantor, Michael N., Reid, Jeffrey G., Yancopoulos, George, Kang, Hyun M., Marchini, Jonathan, Baras, Aris, Abecasis, Gonçalo R., Ferreira, Manuel A. R.
Published in Nature (London) (25.11.2021)
Published in Nature (London) (25.11.2021)
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Journal Article
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity
Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf
Published in Cell (18.04.2019)
Published in Cell (18.04.2019)
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Journal Article
Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease
Hindy, George, Aragam, Krishna G., Ng, Kenney, Chaffin, Mark, Lotta, Luca A., Baras, Aris, Drake, Isabel, Orho-Melander, Marju, Melander, Olle, Kathiresan, Sekar, Khera, Amit V.
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.2020)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.11.2020)
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Journal Article
Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial
Damask, Amy, Steg, P. Gabriel, Schwartz, Gregory G., Szarek, Michael, Hagström, Emil, Badimon, Lina, Chapman, M. John, Boileau, Catherine, Tsimikas, Sotirios, Ginsberg, Henry N., Banerjee, Poulabi, Manvelian, Garen, Pordy, Robert, Hess, Sibylle, Overton, John D., Lotta, Luca A., Yancopoulos, George D., Abecasis, Goncalo R., Baras, Aris, Paulding, Charles
Published in Circulation (New York, N.Y.) (25.02.2020)
Published in Circulation (New York, N.Y.) (25.02.2020)
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Journal Article
Common and rare variant associations with clonal haematopoiesis phenotypes
Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., Jorgenson, Eric
Published in Nature (London) (08.12.2022)
Published in Nature (London) (08.12.2022)
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Journal Article
Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis
Yarmolinsky, James, Bonilla, Carolina, Haycock, Philip C, Langdon, Ryan J Q, Lotta, Luca A, Langenberg, Claudia, Relton, Caroline L, Lewis, Sarah J, Evans, David M, Davey Smith, George, Martin, Richard M
Published in JNCI : Journal of the National Cancer Institute (01.09.2018)
Published in JNCI : Journal of the National Cancer Institute (01.09.2018)
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Journal Article
Calcium, Its Regulatory Hormones, and Their Causal Role on Blood Pressure: A Two-Sample Mendelian Randomization Study
Giontella, Alice, Lotta, Luca A, Baras, Aris, Minuz, Pietro, Gill, Dipender, Melander, Olle, Fava, Cristiano
Published in The journal of clinical endocrinology and metabolism (01.11.2022)
Published in The journal of clinical endocrinology and metabolism (01.11.2022)
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Journal Article
Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors
Lotta, Luca A, Wittemans, Laura B. L, Zuber, Verena, Stewart, Isobel D, Sharp, Stephen J, Luan, Jian’an, Day, Felix R, Li, Chen, Bowker, Nicholas, Cai, Lina, De Lucia Rolfe, Emanuella, Khaw, Kay-Tee, Perry, John R. B, O’Rahilly, Stephen, Scott, Robert A, Savage, David B, Burgess, Stephen, Wareham, Nicholas J, Langenberg, Claudia
Published in JAMA : the journal of the American Medical Association (25.12.2018)
Published in JAMA : the journal of the American Medical Association (25.12.2018)
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Journal Article
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease
Mardinoglu, Adil, Stančáková, Alena, Lotta, Luca A., Kuusisto, Johanna, Boren, Jan, Blüher, Matthias, Wareham, Nicholas J., Ferrannini, Ele, Groop, Per Henrik, Laakso, Markku, Langenberg, Claudia, Smith, Ulf
Published in Cell metabolism (01.08.2017)
Published in Cell metabolism (01.08.2017)
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Journal Article
Deficiency of Peptidylglycine-alpha-amidating Monooxygenase, a Cause of Sarcopenic Diabetes Mellitus
Giontella, Alice, Åkerlund, Mikael, Bronton, Kevin, Fava, Cristiano, Lotta, Luca A, Baras, Aris, Overton, John D, Jones, Marcus, Bergmann, Andreas, Kaufmann, Paul, Ilina, Yulia, Melander, Olle
Published in The journal of clinical endocrinology and metabolism (13.08.2024)
Published in The journal of clinical endocrinology and metabolism (13.08.2024)
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Journal Article
Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse
Smagris, Eriks, Shihanian, Lisa M., Mintah, Ivory J., Bigdelou, Parnian, Livson, Yuliya, Brown, Heather, Verweij, Niek, Hunt, Charleen, Johnson, Reid O’Brien, Greer, Tyler J., Hartford, Suzanne A., Hindy, George, Sun, Luanluan, Nielsen, Jonas B., Halasz, Gabor, Lotta, Luca A., Murphy, Andrew J., Sleeman, Mark W., Gusarova, Viktoria
Published in PLoS genetics (04.03.2024)
Published in PLoS genetics (04.03.2024)
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Journal Article
Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes
Chen, Zhifen, Yu, Haojie, Shi, Xu, Warren, Curtis R., Lotta, Luca A., Friesen, Max, Meissner, Torsten B., Langenberg, Claudia, Wabitsch, Martin, Wareham, Nick, Benson, Mark D., Gerszten, Rob E., Cowan, Chad A.
Published in Circulation research (31.01.2020)
Published in Circulation research (31.01.2020)
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Journal Article
Germline Mutations in CIDEB and Protection against Liver Disease
Verweij, Niek, Haas, Mary E., Nielsen, Jonas B., Sosina, Olukayode A., Kim, Minhee, Akbari, Parsa, De, Tanima, Hindy, George, Bovijn, Jonas, Persaud, Trikaldarshi, Miloscio, Lawrence, Germino, Mary, Panagis, Lampros, Watanabe, Kyoko, Mbatchou, Joelle, Jones, Marcus, LeBlanc, Michelle, Balasubramanian, Suganthi, Lammert, Craig, Enhörning, Sofia, Melander, Olle, Carey, David J., Still, Christopher D., Mirshahi, Tooraj, Rader, Daniel J., Parasoglou, Prodromos, Walls, Johnathon R., Overton, John D., Reid, Jeffrey G., Economides, Aris, Cantor, Michael N., Zambrowicz, Brian, Murphy, Andrew J., Abecasis, Goncalo R., Ferreira, Manuel A.R., Smagris, Eriks, Gusarova, Viktoria, Sleeman, Mark, Yancopoulos, George D., Marchini, Jonathan, Kang, Hyun M., Karalis, Katia, Shuldiner, Alan R., Della Gatta, Giusy, Locke, Adam E., Baras, Aris, Lotta, Luca A.
Published in The New England journal of medicine (28.07.2022)
Published in The New England journal of medicine (28.07.2022)
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Journal Article
Thrombotic risk determined by CREB3L1 variants in a population-based cohort study: linkage disequilibrium with prothrombin mutation
Manderstedt, Eric, Halldén, Christer, Lind-Halldén, Christina, Elf, Johan, Svensson, Peter J., Engström, Gunnar, Melander, Olle, Baras, Aris, Lotta, Luca A., Zöller, Bengt
Published in Journal of thrombosis and haemostasis (01.07.2025)
Published in Journal of thrombosis and haemostasis (01.07.2025)
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Journal Article
Activin E–ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice
Adam, Rene C., Pryce, Dwaine S., Lee, Joseph S., Zhao, Yuanqi, Mintah, Ivory J., Min, Soo, Halasz, Gabor, Mastaitis, Jason, Atwal, Gurinder S., Aykul, Senem, Idone, Vincent, Economides, Aris N., Lotta, Luca A., Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W., Gusarova, Viktoria
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2023)
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Journal Article
Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis
Nead, Kevin T., Sharp, Stephen J., Thompson, Deborah J., Painter, Jodie N., Savage, David B., Semple, Robert K., Barker, Adam, Perry, John R. B., Attia, John, Dunning, Alison M., Easton, Douglas F., Holliday, Elizabeth, Lotta, Luca A., O’Mara, Tracy, McEvoy, Mark, Pharoah, Paul D. P., Scott, Rodney J., Spurdle, Amanda B., Langenberg, Claudia, Wareham, Nicholas J., Scott, Robert A.
Published in JNCI : Journal of the National Cancer Institute (01.09.2015)
Published in JNCI : Journal of the National Cancer Institute (01.09.2015)
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Journal Article
Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting
Giontella, Alice, Sjögren, Marketa, Lotta, Luca A., Overton, John D., Baras, Aris, Minuz, Pietro, Fava, Cristiano, Melander, Olle
Published in Hypertension (Dallas, Tex. 1979) (01.01.2021)
Published in Hypertension (Dallas, Tex. 1979) (01.01.2021)
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Journal Article