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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K. Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O’Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T. W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ
Myers, Michael C., Bilder, Donna M., Cavallaro, Cullen L., Chao, Hannguang J., Su, Shun, Burford, Neil T., Nayeem, Akbar, Wang, Tao, Yan, Mujing, Langish, Robert A., Dabros, Marta, Li, Yi-Xin, Rose, Anne V., Behnia, Kamelia, Onorato, Joelle M., Gargalovic, Peter S., Wexler, Ruth R., Lawrence, R. Michael
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
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Journal Article
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P., Ryono, Denis E., Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A., Williams, Kristin N., Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K. Y., Sun, Jung-Hui, Leith, Leslie W., Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G., Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R., Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O’Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K., Krystek, Stanley R., Spronk, Steven A., Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A., Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B., Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A., Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C., Robl, Jeffrey A., Cheng, Peter T. W.
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
UHPLC-MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions
Kandoussi, Hamza, Zeng, Jianing, Shah, Kumar, Paterson, Patricia, Santockyte, Rasa, Kadiyala, Pathanjali, Shen, Hong, Shipkova, Petia, Langish, Robert, Burrrell, Richard, Easter, John, Mariannino, Thomas, Marathe, Punit, Lai, Yurong, Zhang, Yan, Pillutla, Renuka
Published in Bioanalysis (01.05.2018)
Published in Bioanalysis (01.05.2018)
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Journal Article
11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE−/− Mice
García, Ricardo A., Search, Debra J., Lupisella, John A., Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E., Gargalovic, Peter S., Ryan, Carol S., Watson, Linda M., Langish, Robert A., Shipkova, Petia A., Carson, Nancy L., Taylor, Joseph R., Yang, Richard, Psaltis, George C., Harrity, Thomas W., Robl, Jeffrey A., Gordon, David A.
Published in PloS one (01.02.2013)
Published in PloS one (01.02.2013)
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Journal Article
Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides
Shipkova, Petia, Drexler, Dieter M., Langish, Robert, Smalley, James, Salyan, Mary Ellen, Sanders, Mark
Published in Rapid communications in mass spectrometry (15.05.2008)
Published in Rapid communications in mass spectrometry (15.05.2008)
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Journal Article
A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS
ONORATO, Joelle M, LANGISH, Robert A, SHIPKOVA, Petia A, SANDERS, Mark, WANG, Jennifer, KWAGH, Jae, DUTTA, Sanjoy
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2008)
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Journal Article
A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS 3
Onorato, Joelle M., Langish, Robert A., Shipkova, Petia A., Sanders, Mark, Wang, Jennifer, Kwagh, Jae, Dutta, Sanjoy
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2008)
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Journal Article
Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition
Lai, Yurong, Mandlekar, Sandhya, Shen, Hong, Holenarsipur, Vinay K., Langish, Robert, Rajanna, Prabhakar, Murugesan, Senthilkumar, Gaud, Nilesh, Selvam, Sabariya, Date, Onkar, Cheng, Yaofeng, Shipkova, Petia, Dai, Jun, Humphreys, William G., Marathe, Punit
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
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Journal Article
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects
Shen, Hong, Chen, Weiqi, Drexler, Dieter M., Mandlekar, Sandhya, Holenarsipur, Vinay K., Shields, Eric E., Langish, Robert, Sidik, Kurex, Gan, Jinping, Humphreys, W. Griffith, Marathe, Punit, Lai, Yurong
Published in Drug metabolism and disposition (01.08.2017)
Published in Drug metabolism and disposition (01.08.2017)
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Journal Article
Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry, and Protein Footprinting
Huang, Richard Y.-C, Wang, Feng, Wheeler, Matthew, Wang, Yun, Langish, Robert, Chau, Bryant, Dong, Jia, Morishige, Winse, Bezman, Natalie, Strop, Pavel, Rajpal, Arvind, Gudmundsson, Olafur, Chen, Guodong
Published in Analytical chemistry (Washington) (04.08.2020)
Published in Analytical chemistry (Washington) (04.08.2020)
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Journal Article
Applications of HILIC for targeted and non-targeted LC/MS analyses in drug discovery
Onorato, Joelle M, Langish, Robert, Bellamine, Aouatef, Shipkova, Petia
Published in Journal of separation science (01.03.2010)
Published in Journal of separation science (01.03.2010)
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Journal Article
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor
Wang, Aiying, Dorso, Charles, Kopcho, Lisa, Locke, Gregory, Langish, Robert, Harstad, Eric, Shipkova, Petia, Marcinkeviciene, Jovita, Hamann, Lawrence, Kirby, Mark S
Published in BMC pharmacology (04.04.2012)
Published in BMC pharmacology (04.04.2012)
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Journal Article
A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS3
Onorato, Joelle M., Langish, Robert A., Shipkova, Petia A., Sanders, Mark, Wang, Jennifer, Kwagh, Jae, Dutta, Sanjoy
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2008)
Get full text
Journal Article
11[beta]-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE.sup.-/- Mice
García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A
Published in PloS one (01.02.2013)
Published in PloS one (01.02.2013)
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Journal Article
Antibodies Against IL-7R Alpha Subunit and uses thereof
Scott Ronald BRODEUR, Hong SHEN, Aaron Paul YAMNIUK, Yun WANG, Guodong CHEN, Stephen Michael CARL, Achal Mukundrao PASHINE, Lin Hui SU, Richard Yu-Cheng HUANG, Ekaterina DEYANOVA, Alfred Robert LANGISH
Year of Publication 24.03.2024
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Year of Publication 24.03.2024
Patent
Anticorpos contra subunidade alfa de il-7r e usos dos mesmos
LIN HUI SU, RICHARD YUNG HUANG, ALFRED ROBERT LANGISH, DEYANOVA EKATERINA, STEPHEN MICHAEL CARL, CHEN GUODONG, ACHAL MUKUNDRAO PASHINE, SHEN HONG, AARON PAUL YAMNIUK, WANG YUN, SCOTT RONALD BRODEUR
Year of Publication 13.10.2021
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Year of Publication 13.10.2021
Patent
Antibodies against IL-7R alpha subunit and uses thereof
SHEN, Hong, SU, Lin Hui, LANGISH, Alfred Robert, DEYANOVA, Ekaterina, PASHINE, Achal Mukundrao, BRODEUR, Scott Ronald, YAMNIUK, Aaron Paul, CHEN, Guodong, HUANG, Richard Yu-Cheng, WANG, Yun, CARL, Stephen Michael
Year of Publication 03.04.2025
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Year of Publication 03.04.2025
Patent
ANTIBODIES AGAINST IL-7R ALPHA SUBUNIT AND USES THEREOF
SHEN, Hong, SU, Lin Hui, LANGISH, Alfred Robert, DEYANOVA, Ekaterina, PASHINE, Achal Mukundrao, BRODEUR, Scott Ronald, YAMNIUK, Aaron Paul, CHEN, Guodong, HUANG, Richard Yu-Cheng, WANG, Yun, CARL, Stephen Michael
Year of Publication 26.02.2025
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Year of Publication 26.02.2025
Patent