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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas
Published in Acta neuropathologica (01.08.2018)
Published in Acta neuropathologica (01.08.2018)
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Journal Article
TERT Promoter Mutations and Risk of Recurrence in Meningioma
Sahm, Felix, Schrimpf, Daniel, Olar, Adriana, Koelsche, Christian, Reuss, David, Bissel, Juliane, Kratz, Annekathrin, Capper, David, Schefzyk, Sebastian, Hielscher, Thomas, Wang, Qianghu, Sulman, Erik P., Adeberg, Sebastian, Koch, Arend, Okuducu, Ali Fuat, Brehmer, Stefanie, Schittenhelm, Jens, Becker, Albert, Brokinkel, Benjamin, Schmidt, Melissa, Ull, Theresa, Gousias, Konstantinos, Friederike, Almuth, Lamszus, Kessler, Katrin, Debus, Jürgen, Mawrin, Christian, Kim, Yoo-Jin, Simon, Matthias, Ketter, Ralf, Paulus, Werner, Aldape, Kenneth D., Herold-Mende, Christel, von Deimling, Andreas
Published in JNCI : Journal of the National Cancer Institute (01.05.2016)
Published in JNCI : Journal of the National Cancer Institute (01.05.2016)
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Journal Article
IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO
Reuss, David E., Mamatjan, Yasin, Schrimpf, Daniel, Capper, David, Hovestadt, Volker, Kratz, Annekathrin, Sahm, Felix, Koelsche, Christian, Korshunov, Andrey, Olar, Adriana, Hartmann, Christian, Reijneveld, Jaap C., Wesseling, Pieter, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Herold-Mende, Christel, Aldape, Kenneth, von Deimling, Andreas
Published in Acta neuropathologica (01.06.2015)
Published in Acta neuropathologica (01.06.2015)
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Journal Article
Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group
Roberts, Ryan D., Lizardo, Michael M., Reed, Damon R., Hingorani, Pooja, Glover, Jason, Allen‐Rhoades, Wendy, Fan, Timothy, Khanna, Chand, Sweet‐Cordero, E. Alejandro, Cash, Thomas, Bishop, Michael W., Hegde, Meenakshi, Sertil, Aparna R., Koelsche, Christian, Mirabello, Lisa, Malkin, David, Sorensen, Poul H., Meltzer, Paul S., Janeway, Katherine A., Gorlick, Richard, Crompton, Brian D.
Published in Cancer (15.10.2019)
Published in Cancer (15.10.2019)
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Journal Article
Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature
Koelsche, Christian, Benhamida, Jamal K., Kommoss, Felix K. F., Stichel, Damian, Jones, David T. W., Pfister, Stefan M., Heilig, Christoph E., Fröhling, Stefan, Stenzinger, Albrecht, Buslei, Rolf, Mentzel, Thomas, Baumhoer, Daniel, Ladanyi, Marc, Antonescu, Cristina R., Flucke, Uta, Gorp, Joost van, Bode-Lesniewska, Beata, Deimling, Andreas von, Mechtersheimer, Gunhild
Published in Modern pathology (01.12.2021)
Published in Modern pathology (01.12.2021)
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Journal Article
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas
Published in Acta neuropathologica (01.06.2016)
Published in Acta neuropathologica (01.06.2016)
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Journal Article
Myxoid pleomorphic liposarcoma—a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma
Creytens, David, Folpe, Andrew L., Koelsche, Christian, Mentzel, Thomas, Ferdinande, Liesbeth, van Gorp, Joost M., Van der Linden, Malaïka, Raman, Lennart, Menten, Björn, Fritchie, Karen, von Deimling, Andreas, Van Dorpe, Jo, Flucke, Uta
Published in Modern pathology (01.11.2021)
Published in Modern pathology (01.11.2021)
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Journal Article
Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma
Sahm, Felix, Reuss, David, Koelsche, Christian, Capper, David, Schittenhelm, Jens, Heim, Stephanie, Jones, David T. W., Pfister, Stefan M., Herold-Mende, Christel, Wick, Wolfgang, Mueller, Wolf, Hartmann, Christian, Paulus, Werner, von Deimling, Andreas
Published in Acta neuropathologica (01.10.2014)
Published in Acta neuropathologica (01.10.2014)
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Journal Article
Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system
Koelsche, Christian, Sahm, Felix, Capper, David, Reuss, David, Sturm, Dominik, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Wiestler, Benedikt, Böhmer, Katja, Meyer, Jochen, Mawrin, Christian, Hartmann, Christian, Mittelbronn, Michel, Platten, Michael, Brokinkel, Benjamin, Seiz, Marcel, Herold-Mende, Christel, Unterberg, Andreas, Schittenhelm, Jens, Weller, Michael, Pfister, Stefan, Wick, Wolfgang, Korshunov, Andrey, von Deimling, Andreas
Published in Acta neuropathologica (01.12.2013)
Published in Acta neuropathologica (01.12.2013)
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Journal Article
Methylation-based classification of benign and malignant peripheral nerve sheath tumors
Röhrich, Manuel, Koelsche, Christian, Schrimpf, Daniel, Capper, David, Sahm, Felix, Kratz, Annekathrin, Reuss, Jana, Hovestadt, Volker, Jones, David T. W., Bewerunge-Hudler, Melanie, Becker, Albert, Weis, Joachim, Mawrin, Christian, Mittelbronn, Michel, Perry, Arie, Mautner, Victor-Felix, Mechtersheimer, Gunhild, Hartmann, Christian, Okuducu, Ali Fuat, Arp, Mirko, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Heim, Stefanie, Paulus, Werner, Schittenhelm, Jens, Ahmadi, Rezvan, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., von Deimling, Andreas, Reuss, David E.
Published in Acta neuropathologica (01.06.2016)
Published in Acta neuropathologica (01.06.2016)
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Journal Article
Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
Wegert, Jenny, Vokuhl, Christian, Collord, Grace, Del Castillo Velasco-Herrera, Martin, Farndon, Sarah J., Guzzo, Charlotte, Jorgensen, Mette, Anderson, John, Slater, Olga, Duncan, Catriona, Bausenwein, Sabrina, Streitenberger, Heike, Ziegler, Barbara, Furtwängler, Rhoikos, Graf, Norbert, Stratton, Michael R., Campbell, Peter J., Jones, David TW, Koelsche, Christian, Pfister, Stefan M., Mifsud, William, Sebire, Neil, Sparber-Sauer, Monika, Koscielniak, Ewa, Rosenwald, Andreas, Gessler, Manfred, Behjati, Sam
Published in Nature communications (18.06.2018)
Published in Nature communications (18.06.2018)
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Journal Article
Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup
Kommoss, Felix K.F., Stichel, Damian, Mora, Jaume, Esteller, Manel, Jones, David T.W., Pfister, Stefan M., Brack, Eva, Wachtel, Marco, Bode, Peter Karl, Sinn, Hans-Peter, Schmidt, Dietmar, Mentzel, Thomas, Kommoss, Friedrich, Sahm, Felix, von Deimling, Andreas, Koelsche, Christian
Published in Modern pathology (01.08.2021)
Published in Modern pathology (01.08.2021)
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Journal Article
Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells
Koelsche, Christian, Wöhrer, Adelheid, Jeibmann, Astrid, Schittenhelm, Jens, Schindler, Genevieve, Preusser, Matthias, Lasitschka, Felix, von Deimling, Andreas, Capper, David
Published in Acta neuropathologica (01.06.2013)
Published in Acta neuropathologica (01.06.2013)
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Journal Article
Oligosarcomas, IDH-mutant are distinct and aggressive
Suwala, Abigail K., Felix, Marius, Friedel, Dennis, Stichel, Damian, Schrimpf, Daniel, Hinz, Felix, Hewer, Ekkehard, Schweizer, Leonille, Dohmen, Hildegard, Pohl, Ute, Staszewski, Ori, Korshunov, Andrey, Stein, Marco, Wongsurawat, Thidathip, Cheunsuacchon, Pornsuk, Sathornsumetee, Sith, Koelsche, Christian, Turner, Clinton, Le Rhun, Emilie, Mühlebner, Angelika, Schucht, Philippe, Özduman, Koray, Ono, Takahiro, Shimizu, Hiroaki, Prinz, Marco, Acker, Till, Herold-Mende, Christel, Kessler, Tobias, Wick, Wolfgang, Capper, David, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Hartmann, Christian, Reuss, David E.
Published in Acta neuropathologica (01.02.2022)
Published in Acta neuropathologica (01.02.2022)
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Journal Article
Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma
Wiestler, Benedikt, Capper, David, Sill, Martin, Jones, David T. W., Hovestadt, Volker, Sturm, Dominik, Koelsche, Christian, Bertoni, Anna, Schweizer, Leonille, Korshunov, Andrey, Weiß, Elisa K., Schliesser, Maximilian G., Radbruch, Alexander, Herold-Mende, Christel, Roth, Patrick, Unterberg, Andreas, Hartmann, Christian, Pietsch, Torsten, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard, Platten, Michael, Pfister, Stefan M., von Deimling, Andreas, Weller, Michael, Wick, Wolfgang
Published in Acta neuropathologica (01.10.2014)
Published in Acta neuropathologica (01.10.2014)
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Journal Article
Genomic characterization of DICER1-associated neoplasms uncovers molecular classes
Kommoss, Felix K. F., Chong, Anne-Sophie, Chong, Anne-Laure, Pfaff, Elke, Jones, David T. W., Hiemcke-Jiwa, Laura S., Kester, Lennart A., Flucke, Uta, Gessler, Manfred, Schrimpf, Daniel, Sahm, Felix, Clarke, Blaise A., Stewart, Colin J. R., Wang, Yemin, Gilks, C. Blake, Kommoss, Friedrich, Huntsman, David G., Schüller, Ulrich, Koelsche, Christian, McCluggage, W. Glenn, von Deimling, Andreas, Foulkes, William D.
Published in Nature communications (25.03.2023)
Published in Nature communications (25.03.2023)
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Journal Article
Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations
Reuss, David E., Piro, Rosario M., Jones, David T. W., Simon, Matthias, Ketter, Ralf, Kool, Marcel, Becker, Albert, Sahm, Felix, Pusch, Stefan, Meyer, Jochen, Hagenlocher, Christian, Schweizer, Leonille, Capper, David, Kickingereder, Phillipp, Mucha, Jana, Koelsche, Christian, Jäger, Natalie, Santarius, Thomas, Tarpey, Patrick S., Stephens, Philip J., Andrew Futreal, P., Wellenreuther, Ruth, Kraus, Jürgen, Lenartz, Doris, Herold-Mende, Christel, Hartmann, Christian, Mawrin, Christian, Giese, Nathalia, Eils, Roland, Collins, V. Peter, König, Rainer, Wiestler, Otmar D., Pfister, Stefan M., von Deimling, Andreas
Published in Acta neuropathologica (01.03.2013)
Published in Acta neuropathologica (01.03.2013)
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Journal Article
Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions
Stichel, Damian, Schrimpf, Daniel, Casalini, Belén, Meyer, Jochen, Wefers, Annika K., Sievers, Philipp, Korshunov, Andrey, Koelsche, Christian, Reuss, David E., Reinhardt, Annekathrin, Ebrahimi, Azadeh, Fernández-Klett, Francisco, Kessler, Tobias, Sturm, Dominik, Ecker, Jonas, Milde, Till, Herold-Mende, Christel, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, Jones, David T. W., von Deimling, Andreas, Sahm, Felix
Published in Acta neuropathologica (01.11.2019)
Published in Acta neuropathologica (01.11.2019)
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Journal Article
DNA methylation-based reclassification of olfactory neuroblastoma
Capper, David, Engel, Nils W., Stichel, Damian, Lechner, Matt, Glöss, Stefanie, Schmid, Simone, Koelsche, Christian, Schrimpf, Daniel, Niesen, Judith, Wefers, Annika K., Jones, David T. W., Sill, Martin, Weigert, Oliver, Ligon, Keith L., Olar, Adriana, Koch, Arend, Forster, Martin, Moran, Sebastian, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, Esteller, Manel, Alonso, Javier, del Muro, Xavier Garcia, Paulus, Werner, Felsberg, Jörg, Reifenberger, Guido, Glatzel, Markus, Frank, Stephan, Monoranu, Camelia M., Lund, Valerie J., von Deimling, Andreas, Pfister, Stefan, Buslei, Rolf, Ribbat-Idel, Julika, Perner, Sven, Gudziol, Volker, Meinhardt, Matthias, Schüller, Ulrich
Published in Acta neuropathologica (01.08.2018)
Published in Acta neuropathologica (01.08.2018)
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Journal Article
DNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas
Weidema, Marije E., van de Geer, Ellen, Koelsche, Christian, Desar, Ingrid M.E., Kemmeren, Patrick, Hillebrandt-Roeffen, Melissa H.S., Ho, Vincent K.Y., van der Graaf, Winette T.A., Versleijen-Jonkers, Yvonne M.H., von Deimling, Andreas, Flucke, Uta E.
Published in Clinical cancer research (01.01.2020)
Published in Clinical cancer research (01.01.2020)
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Journal Article