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High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein
Klumpp, Klaus, Lam, Angela M., Lukacs, Christine, Vogel, Robert, Ren, Suping, Espiritu, Christine, Baydo, Ruth, Atkins, Kateri, Abendroth, Jan, Liao, Guochun, Efimov, Andrey, Hartman, George, Flores, Osvaldo A.
Published in Proceedings of the National Academy of Sciences - PNAS (08.12.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (08.12.2015)
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Journal Article
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus
Lam, Angela M., Espiritu, Christine, Vogel, Robert, Ren, Suping, Lau, Vincent, Kelly, Mollie, Kuduk, Scott D., Hartman, George D., Flores, Osvaldo A., Klumpp, Klaus
Published in Antimicrobial agents and chemotherapy (01.01.2019)
Published in Antimicrobial agents and chemotherapy (01.01.2019)
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Journal Article
Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection
Faure-Dupuy, Suzanne, Delphin, Marion, Aillot, Ludovic, Dimier, Laura, Lebossé, Fanny, Fresquet, Judith, Parent, Romain, Matter, Matthias Sebastian, Rivoire, Michel, Bendriss-Vermare, Nathalie, Salvetti, Anna, Heide, Danijela, Flores, Lalo, Klumpp, Klaus, Lam, Angela, Zoulim, Fabien, Heikenwälder, Mathias, Durantel, David, Lucifora, Julie
Published in Journal of hepatology (01.12.2019)
Published in Journal of hepatology (01.12.2019)
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Journal Article
In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir
Tong, Xiao, Le Pogam, Sophie, Li, Lewyn, Haines, Kristin, Piso, Katherine, Baronas, Victoria, Yan, Jun-Mei, So, Sung-Sau, Klumpp, Klaus, Nájera, Isabel
Published in The Journal of infectious diseases (01.03.2014)
Published in The Journal of infectious diseases (01.03.2014)
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Journal Article
CXCL12 ameliorates neutrophilia and disease severity in SARS-CoV-2 infection
Zheng, Jian, Dhakal, Hima, Qing, Enya, Shrestha, Rejeena, Geller, Anne E., Morrissey, Samantha M., Saxena, Divyasha, Hu, Xiaoling, Li, Hong, Li, Haiyan, Wilhelmsen, Kevin, Wendt, Linder H., Klumpp, Klaus, Hume, Patrick S., Janssen, William J., Brody, Rachel, Palmer, Kenneth E., Uriarte, Silvia M., Ten Eyck, Patrick P., Meyerholz, David K., Merchant, Michael L., McLeish, Kenneth, Gallagher, Tom, Huang, Jiapeng, Yan, Jun, Perlman, Stanley
Published in The Journal of clinical investigation (15.02.2025)
Published in The Journal of clinical investigation (15.02.2025)
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Journal Article
Transcriptomic analysis of the woodchuck model of chronic hepatitis B
Fletcher, Simon P., Chin, Daniel J., Ji, Yongmei, Iniguez, A. Leonardo, Taillon, Bruce, Swinney, David C., Ravindran, Palanikumar, Cheng, Donavan T., Bitter, Hans, Lopatin, Uri, Ma, Han, Klumpp, Klaus, Menne, Stephan
Published in Hepatology (Baltimore, Md.) (01.09.2012)
Published in Hepatology (Baltimore, Md.) (01.09.2012)
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Journal Article
Determination of Neuraminidase Kinetic Constants Using Whole Influenza Virus Preparations and Correction for Spectroscopic Interference by a Fluorogenic Substrate
Marathe, Bindumadhav M., Lévêque, Vincent, Klumpp, Klaus, Webster, Robert G., Govorkova, Elena A.
Published in PloS one (15.08.2013)
Published in PloS one (15.08.2013)
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Journal Article
Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479
Ali, Samir, Leveque, Vincent, Le Pogam, Sophie, Ma, Han, Philipp, Friederike, Inocencio, Nicole, Smith, Mark, Alker, Andre, Kang, Hyunsoon, Najera, Isabel, Klumpp, Klaus, Symons, Julian, Cammack, Nick, Jiang, Wen-Rong
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
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Journal Article
H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load
Boon, Adrianus C. M., Finkelstein, David, Zheng, Ming, Liao, Guochun, Allard, John, Klumpp, Klaus, Webster, Robert, Peltz, Gary, Webby, Richard J.
Published in mBio (01.11.2011)
Published in mBio (01.11.2011)
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Journal Article
A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes
Katsume, Asao, Tokunaga, Yuko, Hirata, Yuichi, Munakata, Tsubasa, Saito, Makoto, Hayashi, Hitohisa, Okamoto, Koichi, Ohmori, Yusuke, Kusanagi, Isamu, Fujiwara, Shinya, Tsukuda, Takuo, Aoki, Yuko, Klumpp, Klaus, Tsukiyama–Kohara, Kyoko, El–Gohary, Ahmed, Sudoh, Masayuki, Kohara, Michinori
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2013)
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Journal Article
Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus
Hang, Julie Qi, Yang, Yanli, Harris, Seth F., Leveque, Vincent, Whittington, Hannah J., Rajyaguru, Sonal, Ao-Ieong, Gloria, McCown, Matthew F., Wong, April, Giannetti, Anthony M., Le Pogam, Sophie, Talamás, Francisco, Cammack, Nick, Nájera, Isabel, Klumpp, Klaus
Published in The Journal of biological chemistry (05.06.2009)
Published in The Journal of biological chemistry (05.06.2009)
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Journal Article
The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture
Klumpp, Klaus, Lévêque, Vincent, Le Pogam, Sophie, Ma, Han, Jiang, Wen-Rong, Kang, Hyunsoon, Granycome, Caroline, Singer, Margaret, Laxton, Carl, Hang, Julie Qi, Sarma, Keshab, Smith, David B., Heindl, Dieter, Hobbs, Chris J., Merrett, John H., Symons, Julian, Cammack, Nick, Martin, Joseph A., Devos, Rene, Nájera, Isabel
Published in The Journal of biological chemistry (17.02.2006)
Published in The Journal of biological chemistry (17.02.2006)
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Journal Article
Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
Le Pogam, Sophie, Kang, Hyunsoon, Harris, Seth F., Leveque, Vincent, Giannetti, Anthony M., Ali, Samir, Jiang, Wen-Rong, Rajyaguru, Sonal, Tavares, Gisele, Oshiro, Connie, Hendricks, Than, Klumpp, Klaus, Symons, Julian, Browner, Michelle F., Cammack, Nick, Nájera, Isabel
Published in Journal of Virology (01.06.2006)
Published in Journal of Virology (01.06.2006)
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Journal Article
In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance
Le Pogam, Sophie, Jiang, Wen-Rong, Leveque, Vincent, Rajyaguru, Sonal, Ma, Han, Kang, Hyunsoon, Jiang, Sharon, Singer, Margaret, Ali, Samir, Klumpp, Klaus, Smith, Dave, Symons, Julian, Cammack, Nick, Nájera, Isabel
Published in Virology (New York, N.Y.) (01.08.2006)
Published in Virology (New York, N.Y.) (01.08.2006)
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Journal Article
Structure of the Unphosphorylated STAT5a Dimer
Neculai, Dante, Neculai, Ana Mirela, Verrier, Sophie, Straub, Kenneth, Klumpp, Klaus, Pfitzner, Edith, Becker, Stefan
Published in The Journal of biological chemistry (09.12.2005)
Published in The Journal of biological chemistry (09.12.2005)
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Journal Article