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Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists
Abedini, Amin, Sánchez-Navaro, Andrea, Wu, Junnan, Klötzer, Konstantin A., Ma, Ziyuan, Poudel, Bibek, Doke, Tomohito, Balzer, Michael S., Frederick, Julia, Cernecka, Hana, Liu, Hongbo, Liang, Xiujie, Vitale, Steven, Kolkhof, Peter, Susztak, Katalin
Published in The Journal of clinical investigation (01.01.2024)
Published in The Journal of clinical investigation (01.01.2024)
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Journal Article
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
Abedini, Amin, Levinsohn, Jonathan, Klötzer, Konstantin A., Dumoulin, Bernhard, Ma, Ziyuan, Frederick, Julia, Dhillon, Poonam, Balzer, Michael S., Shrestha, Rojesh, Liu, Hongbo, Vitale, Steven, Bergeson, Andi M., Devalaraja-Narashimha, Kishor, Grandi, Paola, Bhattacharyya, Tanmoy, Hu, Erding, Pullen, Steven S., Boustany-Kari, Carine M., Guarnieri, Paolo, Karihaloo, Anil, Traum, Daniel, Yan, Hanying, Coleman, Kyle, Palmer, Matthew, Sarov-Blat, Lea, Morton, Lori, Hunter, Christopher A., Kaestner, Klaus H., Li, Mingyao, Susztak, Katalin
Published in Nature genetics (01.08.2024)
Published in Nature genetics (01.08.2024)
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Journal Article
TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors
Liang, Xiujie, Liu, Hongbo, Hu, Hailong, Ha, Eunji, Zhou, Jianfu, Abedini, Amin, Sanchez-Navarro, Andrea, Klötzer, Konstantin A., Susztak, Katalin
Published in Nature communications (07.11.2024)
Published in Nature communications (07.11.2024)
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Journal Article
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
Klötzer, Konstantin A., Abedini, Amin, Li, Shen, Balzer, Michael S., Liang, Xiujie, Levinsohn, Jonathan, Ha, Eunji, Dumoulin, Bernhard, Hogan, Jonathan J., Quinn, Ghazal, Bloom, Roy D., Schuller, Max, Eller, Kathrin, Halmos, Balazs, Zhang, Nancy R., Susztak, Katalin
Published in Nature genetics (01.08.2025)
Published in Nature genetics (01.08.2025)
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Journal Article
T cell Activation Marker HLA-DR Reflects Tacrolimus-Associated Immunosuppressive Burden and BK Viremia Risk After Kidney Transplantation – An Observational Cohort Study
Aberger, Simon, Schuller, Max, Mooslechner, Agnes A., Klötzer, Konstantin A., Prietl, Barbara, Pfeifer, Verena, Kirsch, Alexander H., Rosenkranz, Alexander R., Artinger, Katharina, Eller, Kathrin
Published in Transplant international (17.07.2025)
Published in Transplant international (17.07.2025)
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Journal Article
Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients
Mooslechner, Agnes A., Schuller, Max, Pfeifer, Verena, Klötzer, Konstantin A., Prietl, Barbara, Kirsch, Alexander H., Stiegler, Philipp, Sucher, Robert, Sourij, Harald, Rosenkranz, Alexander R., Eller, Kathrin
Published in Transplant international (29.05.2024)
Published in Transplant international (29.05.2024)
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Journal Article
Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis
Artinger, Katharina, Kirsch, Alexander H., Mooslechner, Agnes A., Cooper, Daniel J., Aringer, Ida, Schuller, Max, Schabhüttl, Corinna, Klötzer, Konstantin A., Schweighofer, Kerstin, Eller, Philipp, Yagita, Hideo, Illert, Anna L., Rosenkranz, Alexander R., Lane, Peter J., Eller, Kathrin
Published in Kidney international (01.08.2021)
Published in Kidney international (01.08.2021)
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Journal Article
B Cell Composition Is Altered After Kidney Transplantation and Transitional B Cells Correlate With SARS-CoV-2 Vaccination Response
Schuller, Max, Pfeifer, Verena, Kirsch, Alexander H., Klötzer, Konstantin A., Mooslechner, Agnes A., Rosenkranz, Alexander R., Stiegler, Philipp, Schemmer, Peter, Sourij, Harald, Eller, Philipp, Prietl, Barbara, Eller, Kathrin
Published in Frontiers in medicine (02.02.2022)
Published in Frontiers in medicine (02.02.2022)
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Journal Article
Erythroid ACKR1 Deficiency Aggravates Immune-Mediated Kidney Disease
Artinger, Katharina, Novitzky-Basso, Igor, Klötzer, Konstantin A., Anto-Michel, Nathaly, Schabhuettl, Corinna, Gutjahr, Julia Christine, Samus, Maryna, Hub, Elin, Kirsch, Alexander H., Leitinger, Daniel, Wernitznig, Stefan, Umeizudike, Theophilus, Pollheimer, Marion, Ulvmar, Maria H., Mooslechner, Agnes A., Bacon, Andrea, Eller, Philipp, Kroneis, Thomas, Kratky, Dagmar, Rosenkranz, Alexander R., Eller, Kathrin, Rot, Antal
Published in Journal of the American Society of Nephrology (17.09.2025)
Published in Journal of the American Society of Nephrology (17.09.2025)
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Journal Article
Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis
Liang, Xiujie, Liu, Hongbo, Hu, Hailong, Zhou, Jianfu, Abedini, Amin, Navarro, Andrea Sanchez, Klötzer, Konstantin A, Susztak, Katalin
Published in bioRxiv (07.02.2024)
Published in bioRxiv (07.02.2024)
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Journal Article
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Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression
Abedini, Amin, Levinsohn, Jonathan, Klötzer, Konstantin A, Dumoulin, Bernhard, Ma, Ziyuan, Frederick, Julia, Dhillon, Poonam, Balzer, Michael S, Shrestha, Rojesh, Liu, Hongbo, Vitale, Steven, Devalaraja-Narashimha, Kishor, Grandi, Paola, Bhattacharyya, Tanmoy, Hu, Erding, Pullen, Steven S., Boustany-Kari, Carine M, Guarnieri, Paolo, Karihaloo, Anil, Traum, Daniel, Yan, Hanying, Coleman, Kyle, Palmer, Matthew, Sarov-Blat, Lea, Morton, Lori, Hunter, Christopher A., Kaestner, Klaus H, Li, Mingyao, Susztak, Katalin
Published in bioRxiv (11.02.2024)
Published in bioRxiv (11.02.2024)
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Paper