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The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review
Rugo, Hope S., Jacobs, Ira, Sharma, Shikhar, Scappaticci, Frank, Paul, Thomas A., Jensen-Pergakes, Kristen, Malouf, Gabriel G.
Published in Advances in therapy (01.07.2020)
Published in Advances in therapy (01.07.2020)
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Journal Article
Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
Metz, Patrick J., Ching, Keith A., Xie, Tao, Delgado Cuenca, Paulina, Niessen, Sherry, Tatlock, John H., Jensen-Pergakes, Kristen, Murray, Brion W.
Published in Cell reports (Cambridge) (11.02.2020)
Published in Cell reports (Cambridge) (11.02.2020)
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Journal Article
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation
Ford, Kyle, Munson, Brenton P., Fong, Samson H., Panwala, Rebecca, Chu, Wai Keung, Rainaldi, Joseph, Plongthongkum, Nongluk, Arunachalam, Vinayagam, Kostrowicki, Jarek, Meluzzi, Dario, Kreisberg, Jason F., Jensen-Pergakes, Kristen, VanArsdale, Todd, Paul, Thomas, Tamayo, Pablo, Zhang, Kun, Bienkowska, Jadwiga, Mali, Prashant, Ideker, Trey
Published in Scientific reports (11.05.2023)
Published in Scientific reports (11.05.2023)
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Journal Article
Lenalidomide and CC-4047 Inhibit the Proliferation of Malignant B Cells while Expanding Normal CD34+ Progenitor Cells
Verhelle, Dominique, Corral, Laura G., Wong, Kevin, Mueller, Jessica H., Moutouh-de Parseval, Laure, Jensen-Pergakes, Kristen, Schafer, Peter H., Chen, Roger, Glezer, Emilia, Ferguson, Gregory D., Lopez-Girona, Antonia, Muller, George W., Brady, Helen A., Chan, Kyle W.H.
Published in Cancer research (Chicago, Ill.) (15.01.2007)
Published in Cancer research (Chicago, Ill.) (15.01.2007)
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Journal Article
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation
Ferguson, Gregory D., Delgado, Mercedes, Plantevin-Krenitsky, Veronique, Jensen-Pergakes, Kristen, Bates, R. J., Torres, Sanaa, Celeridad, Maria, Brown, Heather, Burnett, Kelven, Nadolny, Lisa, Tehrani, Lida, Packard, Garrick, Pagarigan, Barbra, Haelewyn, Jason, Nguyen, Trish, Xu, Li, Tang, Yang, Hickman, Matthew, Baculi, Frans, Pierce, Steven, Miyazawa, Keiji, Jackson, Pilgrim, Chamberlain, Philip, LeBrun, Laurie, Xie, Weilin, Bennett, Brydon, Blease, Kate
Published in PloS one (12.01.2016)
Published in PloS one (12.01.2016)
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Journal Article
Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase
Xu, Shuichan, Abbasian, Mahan, Patel, Palka, Jensen-Pergakes, Kristen, Lombardo, Christian R., Cathers, Brian E., Xie, Weilin, Mercurio, Frank, Pagano, Michele, Giegel, David, Cox, Sarah
Published in The Journal of biological chemistry (25.05.2007)
Published in The Journal of biological chemistry (25.05.2007)
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Journal Article
Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism
Escoubet-Lozach, Laure, Lin, I-Lin, Jensen-Pergakes, Kristen, Brady, Helen A., Gandhi, Anita K., Schafer, Peter H., Muller, George W., Worland, Peter J., Chan, Kyle W.H., Verhelle, Dominique
Published in Cancer research (Chicago, Ill.) (15.09.2009)
Published in Cancer research (Chicago, Ill.) (15.09.2009)
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Journal Article
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy
White, Jeffrey, Derheimer, Frederick A., Jensen-Pergakes, Kristen, O’Connell, Shawn, Sharma, Shikhar, Spiegel, Noah, Paul, Thomas A.
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2024)
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2024)
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Journal Article
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance
Jensen-Pergakes, Kristen, Tatlock, John, Maegley, Karen A., McAlpine, Indrawan J., McTigue, Michele, Xie, Tao, Dillon, Christopher P., Wang, Yuli, Yamazaki, Shinji, Spiegel, Noah, Shi, Manli, Nemeth, Amy, Miller, Natalie, Hendrickson, Eleanore, Lam, Hieu, Sherrill, John, Chung, Chi-Yeh, McMillan, Elizabeth A., Bryant, Shannon Karlicek, Palde, Prakash, Braganza, John, Brooun, Alexei, Deng, Ya-Li, Goshtasbi, Vesta, Kephart, Susan E., Kumpf, Robert A., Liu, Wei, Patman, Ryan L., Rui, Eugene, Scales, Stephanie, Tran-Dube, Michelle, Wang, Fen, Wythes, Martin, Paul, Thomas A.
Published in Molecular cancer therapeutics (01.01.2022)
Published in Molecular cancer therapeutics (01.01.2022)
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Journal Article
Abstract 1160: SAM competitive PRMT5 inhibitor PF06939999 demonstrates antitumor activity in splicing dysregulated NSCLC with decreased liability of drug resistance
Jensen-Pergakes, Kristen, Tatlock, John, Maegley, Karen, McAlpine, Indrawan, McTigue, Michele, Xie, Tao, Dillon, Christopher, Wang, Yuli, Yamazaki, Shinji, Spiegel, Noah, Shi, Manli, Nemeth, Amy, Miller, Natalie, Hendrickson, Eleanore, Lam, Hieu, Sherrill, John, Liu, Wei, Deng, Ya-Li, Chung, Chi-Yeh, McMillan, Elizabeth A., Palde, Prakash, Brooun, Alexei, Braganza, John, Kephart, Susan E., Kumpf, Robert, Patman, Ryan, Rui, Eugene, Scales, Stephanie, Tran-Dube, Michelle, Wang, Fen, Wythes, Martin, Paul, Thomas
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
Moutouh-de Parseval, Laure A., Verhelle, Dominique, Glezer, Emilia, Jensen-Pergakes, Kristen, Ferguson, Gregory D., Corral, Laura G., Morris, Christopher L., Muller, George, Brady, Helen, Chan, Kyle
Published in The Journal of clinical investigation (01.01.2008)
Published in The Journal of clinical investigation (01.01.2008)
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Journal Article
Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity
Mcalpine, Indrawan J., Tatlock, John, Billitti, Joseph, Braganza, John, Brooun, Alexei, Ya-Li, Deng, Hirakawa, Brad, Jensen-Pergakes, Kristen, Kumpf, Robert, Liu, Wei, Maegley, Karen, McTigue, Michele, Patman, Ryan, Rui, Eugene, Scales, Stephanie, Spiegel, Noah, Tran-Dubé, Michelle, Wang, Fen, Wang, Zhenxiong, Yamazaki, Shinji, Zhang, Tao, Wythes, Martin
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Receptor-Targeted Gene Delivery Using Multivalent Phagemid Particles
Larocca, David, Jensen-Pergakes, Kristen, Burg, Michael A., Baird, Andrew
Published in Molecular therapy (01.04.2001)
Published in Molecular therapy (01.04.2001)
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Journal Article
Immunomodulatory Drug CC-4047 is a Cell-type and Stimulus-Selective Transcriptional Inhibitor of Cyclooxygenase 2
Ferguson, Gregory D., Jensen-Pergakes, Kristen, Wilkey, Candice, Jhaveri, Urvi, Richard, Normand, Verhelle, Dominique, De Parseval, Laure Moutouh, Corral, Laura G., Xie, Weilin, Morris, Christopher L., Brady, Helen, Chan, Kyle
Published in Journal of Clinical Immunology (01.03.2007)
Published in Journal of Clinical Immunology (01.03.2007)
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Journal Article
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human [CD34.sup.+] cells
Moutouh-de Parseval, Laure A, Verhelle, Dominique, Glezer, Emilia, Jensen-Pergakes, Kristen, Ferguson, Gregory D, Corral, Laura G, Morris, Christopher L, Muller, George, Brady, Helen, Chan, Kyle
Published in The Journal of clinical investigation (01.01.2008)
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Published in The Journal of clinical investigation (01.01.2008)
Journal Article
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34^sup +^ cells
Parseval, Laure A Moutouh-de, Verhelle, Dominique, Glezer, Emilia, Jensen-Pergakes, Kristen, Ferguson, Gregory D, Corral, Laura G, Morris, Christopher L, Muller, George, Brady, Helen, Chan, Kyle
Published in The Journal of clinical investigation (01.01.2008)
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Published in The Journal of clinical investigation (01.01.2008)
Journal Article
Substrate Recognition and Ubiquitination of SCF super(Skp2/Cks1) Ubiquitin-Protein Isopeptide Ligase
Xu, Shuichan, Abbasian, Mahan, Patel, Palka, Jensen-Pergakes, Kristen, Lombardo, Christian R, Cathers, Brian E, Xie, Weilin, Mercurio, Frank, Pagano, Michele, Giegel, David, Cox, Sarah
Published in The Journal of biological chemistry (01.05.2007)
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Published in The Journal of biological chemistry (01.05.2007)
Journal Article
Lenalidomide and CC-4047 Inhibit the Proliferation of Namalwa Cancer Cells While Expanding CD34+ Progenitor Cells. New Insights on the Combination Therapy with Certain HDAC Inhibitors for Hematological Cancers
Verhelle, Dominique, Corral, Laura G., Wong, Kevin, Mueller, Jessica H., de Parseval, Laure Moutouh, Jensen-Pergakes, Kristen, Glezer, Emilia, Ferguson, Gregory D., Brady, Helen A.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Journal Article