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Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
van Weverwijk, Antoinette, Koundouros, Nikolaos, Iravani, Marjan, Ashenden, Matthew, Gao, Qiong, Poulogiannis, George, Jungwirth, Ute, Isacke, Clare M.
Published in Nature communications (20.06.2019)
Published in Nature communications (20.06.2019)
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Journal Article
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
Jungwirth, Ute, van Weverwijk, Antoinette, Evans, Rachel J., Jenkins, Liam, Vicente, David, Alexander, John, Gao, Qiong, Haider, Syed, Iravani, Marjan, Isacke, Clare M.
Published in Nature communications (10.06.2021)
Published in Nature communications (10.06.2021)
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Journal Article
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Avgustinova, Alexandra, Iravani, Marjan, Robertson, David, Fearns, Antony, Gao, Qiong, Klingbeil, Pamela, Hanby, Andrew M., Speirs, Valerie, Sahai, Erik, Calvo, Fernando, Isacke, Clare M.
Published in Nature communications (18.01.2016)
Published in Nature communications (18.01.2016)
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Journal Article
International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations
Meattini, Icro, Becherini, Carlotta, Caini, Saverio, Coles, Charlotte E, Cortes, Javier, Curigliano, Giuseppe, de Azambuja, Evandro, Isacke, Clare M, Harbeck, Nadia, Kaidar-Person, Orit, Marangoni, Elisabetta, Offersen, Birgitte V, Rugo, Hope S, Salvestrini, Viola, Visani, Luca, Morandi, Andrea, Lambertini, Matteo, Poortmans, Philip, Livi, Lorenzo, Alkner, Sara, Bhattacharya, Indrani S., Boersma, Liesbeth, Callari, Maurizio, Clarke, Robert B., Del Mastro, Lucia, Ekholm, Maria, Gennari, Alessandra, Kirby, Anna M., Kroeze, Stephanie, Malumbres, Marcos, Vestmø Maraldo, Maja, Marta, Gustavo Nader, Mjaaland, Ingvil, Morgan, Gilberto, Pistilli, Barbara, Paluch-Shimon, Shani, Rivera, Sofia, Rottenberg, Sven, Saura, Cristina, Skyttä, Tanja, Spanic, Tanja
Published in The lancet oncology (01.02.2024)
Published in The lancet oncology (01.02.2024)
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Journal Article
Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype
Fitzpatrick, Amanda, Iravani, Marjan, Mills, Adam, Vicente, David, Alaguthurai, Thanussuyah, Roxanis, Ioannis, Turner, Nicholas C., Haider, Syed, Tutt, Andrew N. J., Isacke, Clare M.
Published in Nature communications (16.11.2023)
Published in Nature communications (16.11.2023)
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Journal Article
Endosialin-Expressing Pericytes Promote Metastatic Dissemination
Viski, Carmen, König, Courtney, Kijewska, Magdalena, Mogler, Carolin, Isacke, Clare M., Augustin, Hellmut G.
Published in Cancer research (Chicago, Ill.) (15.09.2016)
Published in Cancer research (Chicago, Ill.) (15.09.2016)
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Journal Article
miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors
Bacci, Marina, Giannoni, Elisa, Fearns, Antony, Ribas, Ricardo, Gao, Qiong, Taddei, Maria Letizia, Pintus, Gianfranco, Dowsett, Mitch, Isacke, Clare M., Martin, Lesley-Ann, Chiarugi, Paola, Morandi, Andrea
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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Journal Article
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
Araujo, Angela M., Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I., Manzano, Sara, Rodriguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Alvarez-Lopez, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M., Caffarel, María M., Lawrie, Charles H.
Published in The Journal of clinical investigation (01.04.2022)
Published in The Journal of clinical investigation (01.04.2022)
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Journal Article
MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes
Castilla, María Ángeles, Díaz-Martín, Juan, Sarrió, David, Romero-Pérez, Laura, López-García, María Ángeles, Vieites, Begoña, Biscuola, Michele, Ramiro-Fuentes, Susana, Isacke, Clare M., Palacios, José
Published in PloS one (24.10.2012)
Published in PloS one (24.10.2012)
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Journal Article
RET in breast cancer: functional and therapeutic implications
Morandi, Andrea, Plaza-Menacho, Ivan, Isacke, Clare M.
Published in Trends in molecular medicine (01.03.2011)
Published in Trends in molecular medicine (01.03.2011)
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Journal Article
GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Morandi, Andrea, Martin, Lesley-Ann, Gao, Qiong, Pancholi, Sunil, Mackay, Alan, Robertson, David, Zvelebil, Marketa, Dowsett, Mitch, Plaza-Menacho, Ivan, Isacke, Clare M.
Published in Cancer research (Chicago, Ill.) (15.06.2013)
Published in Cancer research (Chicago, Ill.) (15.06.2013)
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Journal Article
Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain
Kijewska, Magdalena, Viski, Carmen, Turrell, Frances, Fitzpatrick, Amanda, van Weverwijk, Antoinette, Gao, Qiong, Iravani, Marjan, Isacke, Clare M.
Published in Breast cancer research : BCR (14.01.2019)
Published in Breast cancer research : BCR (14.01.2019)
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Journal Article
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
Araujo, Angela M., Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I., Manzano, Sara, Rodriguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Alvarez-Lopez, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M., Caffarel, María M., Lawrie, Charles H.
Published in The Journal of clinical investigation (03.10.2022)
Published in The Journal of clinical investigation (03.10.2022)
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Journal Article
Pericytes promote selective vessel regression to regulate vascular patterning
Simonavicius, Nicole, Ashenden, Matthew, van Weverwijk, Antoinette, Lax, Siân, Huso, David L., Buckley, Christopher D., Huijbers, Ivo J., Yarwood, Helen, Isacke, Clare M.
Published in Blood (16.08.2012)
Published in Blood (16.08.2012)
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Journal Article
CD44 increases the efficiency of distant metastasis of breast cancer
McFarlane, Suzanne, Coulter, Jonathan A., Tibbits, Paul, O'Grady, Anthony, McFarlane, Cheryl, Montgomery, Nicola, Hill, Ashleigh, McCarthy, Helen O., Young, Leonie S., Kay, Elaine W., Isacke, Clare M., Waugh, David J.J.
Published in Oncotarget (10.05.2015)
Published in Oncotarget (10.05.2015)
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Journal Article
Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis
Ash, Sarah L, Orha, Rebecca, Mole, Holly, Dinesh-Kumar, Meg, Lee, Steven P, Turrell, Frances K, Isacke, Clare M
Published in Journal for immunotherapy of cancer (27.02.2024)
Published in Journal for immunotherapy of cancer (27.02.2024)
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Journal Article
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
Sims, David, Mendes-Pereira, Ana M, Frankum, Jessica, Burgess, Darren, Cerone, Maria-Antonietta, Lombardelli, Cristina, Mitsopoulos, Costas, Hakas, Jarle, Murugaesu, Nirupa, Isacke, Clare M, Fenwick, Kerry, Assiotis, Ioannis, Kozarewa, Iwanka, Zvelebil, Marketa, Ashworth, Alan, Lord, Christopher J
Published in Genome biology (21.10.2011)
Published in Genome biology (21.10.2011)
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Journal Article