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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
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Journal Article
Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
Eller, Kathrin, Kirsch, Alexander, Wolf, Anna M., Sopper, Sieghart, Tagwerker, Andrea, Stanzl, Ursula, Wolf, Dominik, Patsch, Wolfgang, Rosenkranz, Alexander R., Eller, Philipp
Published in Diabetes (New York, N.Y.) (01.11.2011)
Published in Diabetes (New York, N.Y.) (01.11.2011)
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Journal Article
Aiolos Promotes Anchorage Independence by Silencing p66Shc Transcription in Cancer Cells
Li, Xichuan, Xu, Zhao, Du, Wei, Zhang, Zhenfa, Wei, Yiliang, Wang, Hao, Zhu, Zhiyan, Qin, Litao, Wang, Lin, Niu, Qing, Zhao, Xiulan, Girard, Luc, Gong, Yimei, Ma, Zhenyi, Sun, Baocun, Yao, Zhi, Minna, John D., Terada, Lance S., Liu, Zhe
Published in Cancer cell (12.05.2014)
Published in Cancer cell (12.05.2014)
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Journal Article
T-cell regulation during viral and nonviral asthma exacerbations
Wegrzyn, Agnieszka S., Jakiela, Bogdan, Rückert, Beate, Jutel, Marek, Akdis, Mübeccel, Sanak, Marek, Akdis, Cezmi A.
Published in Journal of allergy and clinical immunology (01.07.2015)
Published in Journal of allergy and clinical immunology (01.07.2015)
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Journal Article
Regulatory T cells: Friends or foe in human Mycobacterium leprae infection?
Chaves, Ana T., Ribeiro-Junior, Atvaldo F., Lyon, Sandra, Medeiros, Nayara I., Cassirer-Costa, Fábio, Paula, Karina S., Alecrim, Edilamar S., Menezes, Cristiane A.S., Correa-Oliveira, Rodrigo, Rocha, Manoel O.C., Gomes, Juliana A.S.
Published in Immunobiology (1979) (01.04.2018)
Published in Immunobiology (1979) (01.04.2018)
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Journal Article
Foxp3+ Treg Expanded from Patients with Established Diabetes Reduce Helios Expression while Retaining Normal Function Compared to Healthy Individuals
Du, Weiting, Shen, Yueh-Wei, Lee, Wen-Hui, Wang, Ding, Paz, Sachiko, Kandeel, Fouad, Liu, Chih-Pin
Published in PloS one (11.02.2013)
Published in PloS one (11.02.2013)
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Journal Article
Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase
Ma, Hong, Qazi, Sanjive, Ozer, Zahide, Zhang, Jian, Ishkhanian, Rita, Uckun, Fatih M.
Published in PloS one (19.08.2013)
Published in PloS one (19.08.2013)
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Journal Article
Constitutive Function of the Ikaros Transcription Factor in Primary Leukemia Cells from Pediatric Newly Diagnosed High-Risk and Relapsed B-precursor ALL Patients
Uckun, Fatih M., Ma, Hong, Ishkhanian, Rita, Arellano, Martha, Shahidzadeh, Anoush, Termuhlen, Amanda, Gaynon, Paul S., Qazi, Sanjive
Published in PloS one (20.11.2013)
Published in PloS one (20.11.2013)
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Journal Article