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Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation
Viho, Eva M.G., Buurstede, Jacobus C., Mahfouz, Ahmed, Koorneef, Lisa L., van Weert, Lisa T.C.M., Houtman, René, Hunt, Hazel J., Kroon, Jan, Meijer, Onno C.
Published in Neuroendocrinology (01.09.2019)
Published in Neuroendocrinology (01.09.2019)
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Journal Article
Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition
Viho, Eva M G, Kroon, Jan, Feelders, Richard A, Houtman, René, van den Dungen, Elisabeth S R, Pereira, Alberto M, Hunt, Hazel J, Hofland, Leo J, Meijer, Onno C
Published in Journal of endocrinology (01.02.2023)
Published in Journal of endocrinology (01.02.2023)
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Journal Article
Identification of the Clinical Candidate (R)‑(1-(4-Fluorophenyl)-6-((1-methyl‑1H‑pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro‑1H‑pyrazolo[3,4‑g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist
Hunt, Hazel J, Belanoff, Joseph K, Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, Leandro F., Estey, David, Goodell, Vivian, Macshane, Lauren G., Logrip, Marian L., Schlosburg, Joel E., McGinn, M. Adrienne, Zamora-Martinez, Eva R., Belanoff, Joseph K., Hunt, Hazel J., Sanna, Pietro P., George, Olivier, Koob, George F., Edwards, Scott, Mason, Barbara J.
Published in The Journal of clinical investigation (01.08.2015)
Published in The Journal of clinical investigation (01.08.2015)
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Journal Article
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats
McGinn, M. Adrienne, Tunstall, Brendan J., Schlosburg, Joel E., Gregory-Flores, Adriana, George, Olivier, de Guglielmo, Giordano, Mason, Barbara J., Hunt, Hazel J., Koob, George F., Vendruscolo, Leandro F.
Published in Neuropharmacology (01.05.2021)
Published in Neuropharmacology (01.05.2021)
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Journal Article
Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Published in British journal of pharmacology (01.03.2017)
Published in British journal of pharmacology (01.03.2017)
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Journal Article
Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice
Kroon, Jan, Koorneef, Lisa L, van den Heuvel, Jose K, Verzijl, Cristy R C, van de Velde, Nienke M, Mol, Isabel M, Sips, Hetty C M, Hunt, Hazel, Rensen, Patrick C N, Meijer, Onno C
Published in Endocrinology (Philadelphia) (01.01.2018)
Published in Endocrinology (Philadelphia) (01.01.2018)
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Journal Article
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator
Zalachoras, Ioannis, Houtman, René, Atucha, Erika, Devos, Rene, Tijssen, Ans M. I., Hu, Pu, Lockey, Peter M., Datson, Nicole A., Belanoff, Joseph K., Lucassen, Paul J., Joëls, Marian, de Kloet, E. Ronald, Roozendaal, Benno, Hunt, Hazel, Meijer, Onno C.
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
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Journal Article
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile
Hunt, Hazel J., Belanoff, Joseph K., Golding, Emily, Gourdet, Benoit, Phillips, Timothy, Swift, Denise, Thomas, Jennifer, Unitt, John F., Walters, Iain
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Journal Article
Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses
Kootar, Scherazad, Frandemiche, Marie-Lise, Dhib, Gihen, Mouska, Xavier, Lorivel, Thomas, Poupon-Silvestre, Gwenola, Hunt, Hazel, Tronche, François, Bethus, Ingrid, Barik, Jacques, Marie, Hélène
Published in Neurobiology of disease (01.10.2018)
Published in Neurobiology of disease (01.10.2018)
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Journal Article
Effects of Selective and Non-Selective Glucocorticoid Receptor II Antagonists on Rapid-Onset Diabetes in Young Rats
Beaudry, Jacqueline L., Dunford, Emily C., Teich, Trevor, Zaharieva, Dessi, Hunt, Hazel, Belanoff, Joseph K., Riddell, Michael C.
Published in PloS one (18.03.2014)
Published in PloS one (18.03.2014)
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Journal Article
An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model
Al-Hity, Gheed, Yang, FengWei, Campillo-Funollet, Eduard, Greenstein, Andrew E., Hunt, Hazel, Mampay, Myrthe, Intabli, Haya, Falcinelli, Marta, Madzvamuse, Anotida, Venkataraman, Chandrasekhar, Flint, Melanie S.
Published in Communications biology (24.06.2021)
Published in Communications biology (24.06.2021)
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Journal Article
FKBP5 mRNA Expression Is a Biomarker for GR Antagonism
Bali, Utsav, Phillips, Tim, Hunt, Hazel, Unitt, John
Published in The journal of clinical endocrinology and metabolism (01.11.2016)
Published in The journal of clinical endocrinology and metabolism (01.11.2016)
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Journal Article
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat
Hunt, Hazel J., Ray, Nicholas C., Hynd, George, Sutton, Jon, Sajad, Mohammed, O’Connor, Elizabeth, Ahmed, Shahadat, Lockey, Peter, Daly, Steve, Buckley, Gerry, Clark, Robin D., Roe, Robert, Blasey, Christine, Belanoff, Joe
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Journal Article
SAT-422 Effect of hepatic impairment on the pharmacokinetics of Miricorilant: results from a phase 1, open-label, adaptive-design study
Custodio, Joseph M., Donaldson, Kirsteen, Kunta, Jeevan, Juneja, Kavita, Hunt, Hazel J.
Published in Journal of hepatology (01.05.2025)
Published in Journal of hepatology (01.05.2025)
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Journal Article
FKBP5 mRNA Expression Is a Biomarker for GR Antagonism
Bali, Utsav, Phillips, Tim, Hunt, Hazel, Unitt, John
Published in The journal of clinical endocrinology and metabolism (01.11.2016)
Published in The journal of clinical endocrinology and metabolism (01.11.2016)
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Journal Article