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Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
Nguyen, Trang T. T., Shang, Enyuan, Shu, Chang, Kim, Sungsoo, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Yang, Hee Won, Akman, Hasan Orhan, Quinzii, Catarina M., Zhang, Guoan, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Published in Nature communications (01.09.2021)
Published in Nature communications (01.09.2021)
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Journal Article
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
Upadhyayula, Pavan S., Higgins, Dominique M., Mela, Angeliki, Banu, Matei, Dovas, Athanassios, Zandkarimi, Fereshteh, Patel, Purvi, Mahajan, Aayushi, Humala, Nelson, Nguyen, Trang T. T., Chaudhary, Kunal R., Liao, Lillian, Argenziano, Michael, Sudhakar, Tejaswi, Sperring, Colin P., Shapiro, Benjamin L., Ahmed, Eman R., Kinslow, Connor, Ye, Ling F., Siegelin, Markus D., Cheng, Simon, Soni, Rajesh, Bruce, Jeffrey N., Stockwell, Brent R., Canoll, Peter
Published in Nature communications (02.03.2023)
Published in Nature communications (02.03.2023)
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Journal Article
Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states
Al-Dalahmah, Osama, Argenziano, Michael G., Kannan, Adithya, Mahajan, Aayushi, Furnari, Julia, Paryani, Fahad, Boyett, Deborah, Save, Akshay, Humala, Nelson, Khan, Fatima, Li, Juncheng, Lu, Hong, Sun, Yu, Tuddenham, John F., Goldberg, Alexander R., Dovas, Athanassios, Banu, Matei A., Sudhakar, Tejaswi, Bush, Erin, Lassman, Andrew B., McKhann, Guy M., Gill, Brian J. A., Youngerman, Brett, Sisti, Michael B., Bruce, Jeffrey N., Sims, Peter A., Menon, Vilas, Canoll, Peter
Published in Nature communications (04.05.2023)
Published in Nature communications (04.05.2023)
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Journal Article
Ex Vivo Modeling of Malignant Pineal Tumors Using Viral Transformation of Transgenic Murine Pineal Gland Cultures
Higgins, Dominique, Upadhyayula, Pavan S, Humala, Nelson, Mahajan, Aayushi, Mela, Angeliki, Sudhakar, Tejaswi, Zacharoulis, Stergios, Feldstein, Neil A, Canoll, Peter D, Bruce, Jeffrey N
Published in Neurosurgery (01.12.2020)
Published in Neurosurgery (01.12.2020)
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Journal Article
Dietary Alteration of Cysteine and Methionine Sensitizes Gliomas to Ferroptosis Inducing Agents and Radiation
Upadhyayula, Pavan S, Higgins, Dominique, Dovas, Athanassios, Mela, Angeliki, Chaudhaury, Kunal, Mahajan, Aayushi, Humala, Nelson, Sudhakar, Tejaswi, Kinslow, Connor, Stockwell, Brent, Canoll, Peter D, Bruce, Jeffrey N
Published in Neurosurgery (01.12.2020)
Published in Neurosurgery (01.12.2020)
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Journal Article
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
Zhao, Zhong, Lange, Dale J, Voustianiouk, Andrei, MacGrogan, Donal, Ho, Lap, Suh, Jason, Humala, Nelson, Thiyagarajan, Meenakshisundaram, Wang, Jun, Pasinetti, Giulio M
Published in BMC neuroscience (03.04.2006)
Published in BMC neuroscience (03.04.2006)
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Journal Article
EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor
Sprinzen, Lisa, Garcia, Franklin, Mela, Angeliki, Lei, Liang, Upadhyayula, Pavan, Mahajan, Aayushi, Humala, Nelson, Manier, Lisa, Caprioli, Richard, Quiñones-Hinojosa, Alfredo, Casaccia, Patrizia, Canoll, Peter
Published in Cells (Basel, Switzerland) (01.01.2024)
Published in Cells (Basel, Switzerland) (01.01.2024)
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Journal Article
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma
Nguyen, Trang T.T., Torrini, Consuelo, Shang, Enyuan, Shu, Chang, Mun, Jeong-Yeon, Gao, Qiuqiang, Humala, Nelson, Akman, Hasan O., Zhang, Guoan, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Published in JCI insight (14.03.2024)
Published in JCI insight (14.03.2024)
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Journal Article
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models
Nguyen, Trang Thi Thu, Zhang, Yiru, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhao, Junfei, Bianchetti, Elena, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Harmanci, Arif O., Lei, Zhengdeng, Maienschein-Cline, Mark, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Published in The Journal of clinical investigation (01.07.2020)
Published in The Journal of clinical investigation (01.07.2020)
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Journal Article
Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APP.sup.V717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
Qu, Wenhui, Lam, Matti, McInvale, Julie J, Mares, Jason A, Kwon, Sam, Humala, Nelson, Mahajan, Aayushi
Published in Acta neuropathologica (01.06.2024)
Published in Acta neuropathologica (01.06.2024)
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Journal Article
Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma
Torrini, Consuelo, Nguyen, Trang Thi Thu, Shu, Chang, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Seeley, Erin Heather, Zhang, Guoan, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Published in Molecular cell (18.08.2022)
Published in Molecular cell (18.08.2022)
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Journal Article
Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition
Goldberg, Alexander R, Dovas, Athanassios, Torres, Daniela, Sharma, Sohani Das, Mela, Angeliki, Merricks, Edward M, Olabarria, Markel, Shokooh, Leila Abrishami, Zhao, Hanzhi T, Kotidis, Corina, Calvaresi, Peter, Viswanathan, Ashwin, Banu, Matei A, Razavilar, Aida, Sudhakar, Tejaswi D, Saxena, Ankita, Chokran, Cole, Humala, Nelson, Mahajan, Aayushi, Xu, Weihao, Metz, Jordan B, Chen, Cady, Bushong, Eric A, Boassa, Daniela, Ellisman, Mark H, Hillman, Elizabeth M C, McKhann, 2nd, Guy M, Gill, Brian J A, Rosenfeld, Steven S, Schevon, Catherine A, Bruce, Jeffrey N, Sims, Peter A, Peterka, Darcy S, Canoll, Peter
Published in bioRxiv (21.01.2024)
Published in bioRxiv (21.01.2024)
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Journal Article
Paper
Grape-Derived Polyphenolics Prevent A beta Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease
Wang, Jun, Ho, Lap, Zhao, Wei, Ono, Kenjiro, Rosensweig, Clark, Chen, Linghong, Humala, Nelson, Teplow, David B, Pasinetti, Giulio M
Published in The Journal of neuroscience (18.06.2008)
Published in The Journal of neuroscience (18.06.2008)
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Journal Article
A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma
Banu, Matei A, Dovas, Athanassios, Argenziano, Michael G, Zhao, Wenting, Cuervo, Henar, Higgins, Dominique Mo, Sperring, Colin P, Pereira, Brianna, Ye, Ling F, Mahajan, Aayushi, Nelson Humala, Furnari, Julia L, Upadhyayula, Pavan S, Zandkarimi, Fereshteh, Nguyen, Trang Tt, Wu, Peter B, Li, Hai, Karan, Charles, Razavilar, Aida, Siegelin, Markus D, Kitajewski, Jan, Bruce, Jeffrey N, Stockwell, Brent R, Sims, Peter A, Canoll, Peter D
Published in bioRxiv (23.02.2023)
Published in bioRxiv (23.02.2023)
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Paper
Journal Article
Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
Wang, Jun, Ho, Lap, Chen, Linghong, Zhao, Zhong, Zhao, Wei, Qian, Xianjuan, Humala, Nelson, Seror, Ilana, Bartholomew, Sadie, Rosendorff, Clive, Pasinetti, Giulio Maria
Published in The Journal of clinical investigation (01.11.2007)
Published in The Journal of clinical investigation (01.11.2007)
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Journal Article
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial
Spinazzi, Eleonora F, Argenziano, Michael G, Upadhyayula, Pavan S, Banu, Matei A, Neira, Justin A, Higgins, Dominique M O, Wu, Peter B, Pereira, Brianna, Mahajan, Aayushi, Humala, Nelson, Al-Dalahmah, Osama, Zhao, Wenting, Save, Akshay V, Gill, Brian J A, Boyett, Deborah M, Marie, Tamara, Furnari, Julia L, Sudhakar, Tejaswi D, Stopka, Sylwia A, Regan, Michael S, Catania, Vanessa, Good, Laura, Zacharoulis, Stergios, Behl, Meenu, Petridis, Petros, Jambawalikar, Sachin, Mintz, Akiva, Lignelli, Angela, Agar, Nathalie Y R, Sims, Peter A, Welch, Mary R, Lassman, Andrew B, Iwamoto, Fabio M, D’Amico, Randy S, Grinband, Jack, Canoll, Peter, Bruce, Jeffrey N
Published in The lancet oncology (01.11.2022)
Published in The lancet oncology (01.11.2022)
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Journal Article
Glioma-Induced Alterations in Neuronal Activity and Neurovascular Coupling during Disease Progression
Montgomery, Mary Katherine, Kim, Sharon H., Dovas, Athanassios, Zhao, Hanzhi T., Goldberg, Alexander R., Xu, Weihao, Yagielski, Alexis J., Cambareri, Morgan K., Patel, Kripa B., Mela, Angeliki, Humala, Nelson, Thibodeaux, David N., Shaik, Mohammed A., Ma, Ying, Grinband, Jack, Chow, Daniel S., Schevon, Catherine, Canoll, Peter, Hillman, Elizabeth M.C.
Published in Cell reports (Cambridge) (14.04.2020)
Published in Cell reports (Cambridge) (14.04.2020)
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Journal Article
MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma
Zhang, Yiru, Nguyen, Trang T.T., Shang, Enyuan, Mela, Angeliki, Humala, Nelson, Mahajan, Aayushi, Zhao, Junfei, Shu, Chang, Torrini, Consuelo, Sanchez-Quintero, Maria J., Kleiner, Giulio, Bianchetti, Elena, Westhoff, Mike-Andrew, Quinzii, Catarina M., Karpel-Massler, Georg, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Published in Cancer research (Chicago, Ill.) (01.01.2020)
Published in Cancer research (Chicago, Ill.) (01.01.2020)
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Journal Article
DDEL-17. INTRA-TUMORAL CONVECTION ENHANCED DELIVERY OF DEXAMETHASONE REDUCES INFLAMMATORY SIGNATURES AND EXTENDS SURVIVAL IN GBM MODEL
Dadario, Nicholas, Teasley, Damian, Lei, Liang, Rolfe, Nathaniel, Winans, Nathan, Kotidis, Corina, Khoury, Nadine, Yoh, Nina, Furnari, Julia, Sperring, Colin, Upadhyayula, Pavan, Ifediora, Nkechime, Humala, Nelson, Mahajan, Aayushi, Zhao, Wenting, Gill, Brian, Sims, Peter, Canoll, Peter, Bruce, Jeffrey
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2024)
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Journal Article
A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures
Rifkin, Robert A., Wu, Xiaoping, Pereira, Brianna, Gill, Brian JA, Merricks, Edward M., Michalak, Andrew J., Goldberg, Alexander R., Humala, Nelson, Dovas, Athanassios, Rai, Ganesha, McKhann, Guy M., Slesinger, Paul A., Canoll, Peter, Schevon, Catherine
Published in Neuropharmacology (01.03.2025)
Published in Neuropharmacology (01.03.2025)
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Journal Article