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A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs
Réa, Delphine, Mauro, Michael J., Boquimpani, Carla, Minami, Yosuke, Lomaia, Elza, Voloshin, Sergey, Turkina, Anna, Kim, Dong-Wook, Apperley, Jane F., Abdo, Andre, Fogliatto, Laura Maria, Kim, Dennis Dong Hwan, le Coutre, Philipp, Saussele, Susanne, Annunziata, Mario, Hughes, Timothy P., Chaudhri, Naeem, Sasaki, Koji, Chee, Lynette, García-Gutiérrez, Valentin, Cortes, Jorge E., Aimone, Paola, Allepuz, Alex, Quenet, Sara, Bédoucha, Véronique, Hochhaus, Andreas
Published in Blood (25.11.2021)
Published in Blood (25.11.2021)
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Journal Article
Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia
Hochhaus, Andreas, Larson, Richard A, Guilhot, François, Radich, Jerald P, Branford, Susan, Hughes, Timothy P, Baccarani, Michele, Deininger, Michael W, Cervantes, Francisco, Fujihara, Satoko, Ortmann, Christine-Elke, Menssen, Hans D, Kantarjian, Hagop, O’Brien, Stephen G, Druker, Brian J
Published in The New England journal of medicine (09.03.2017)
Published in The New England journal of medicine (09.03.2017)
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Journal Article
Ponatinib efficacy and safety in Philadelphia chromosome–positive leukemia: final 5-year results of the phase 2 PACE trial
Cortes, Jorge E., Kim, Dong-Wook, Pinilla-Ibarz, Javier, le Coutre, Philipp D., Paquette, Ronald, Chuah, Charles, Nicolini, Franck E., Apperley, Jane F., Khoury, H. Jean, Talpaz, Moshe, DeAngelo, Daniel J., Abruzzese, Elisabetta, Rea, Delphine, Baccarani, Michele, Müller, Martin C., Gambacorti-Passerini, Carlo, Lustgarten, Stephanie, Rivera, Victor M., Haluska, Frank G., Guilhot, François, Deininger, Michael W., Hochhaus, Andreas, Hughes, Timothy P., Shah, Neil P., Kantarjian, Hagop M.
Published in Blood (26.07.2018)
Published in Blood (26.07.2018)
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Journal Article
The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1
Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.
Published in Nature (London) (30.03.2017)
Published in Nature (London) (30.03.2017)
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Journal Article
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
Baccarani, Michele, Deininger, Michael W., Rosti, Gianantonio, Hochhaus, Andreas, Soverini, Simona, Apperley, Jane F., Cervantes, Francisco, Clark, Richard E., Cortes, Jorge E., Guilhot, François, Hjorth-Hansen, Henrik, Hughes, Timothy P., Kantarjian, Hagop M., Kim, Dong-Wook, Larson, Richard A., Lipton, Jeffrey H., Mahon, François-Xavier, Martinelli, Giovanni, Mayer, Jiri, Müller, Martin C., Niederwieser, Dietger, Pane, Fabrizio, Radich, Jerald P., Rousselot, Philippe, Saglio, Giuseppe, Saußele, Susanne, Schiffer, Charles, Silver, Richard, Simonsson, Bengt, Steegmann, Juan-Luis, Goldman, John M., Hehlmann, Rüdiger
Published in Blood (08.08.2013)
Published in Blood (08.08.2013)
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Journal Article
Asciminib for Philadelphia chromosome positive leukemias
Hughes, Timothy P., White, Deborah L., Yeung, David T.
Published in Haematologica (Roma) (26.06.2025)
Published in Haematologica (Roma) (26.06.2025)
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Journal Article
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., Zeiser, Robert
Published in Nature communications (08.11.2021)
Published in Nature communications (08.11.2021)
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Journal Article
Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia
Branford, Susan, Kim, Dennis Dong Hwan, Apperley, Jane F., Eide, Christopher A., Mustjoki, Satu, Ong, S. Tiong, Nteliopoulos, Georgios, Ernst, Thomas, Chuah, Charles, Gambacorti-Passerini, Carlo, Mauro, Michael J., Druker, Brian J., Kim, Dong-Wook, Mahon, Francois-Xavier, Cortes, Jorge, Radich, Jerry P., Hochhaus, Andreas, Hughes, Timothy P.
Published in Leukemia (01.08.2019)
Published in Leukemia (01.08.2019)
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Journal Article
Asciminib in Newly Diagnosed Chronic Myeloid Leukemia
Hochhaus, Andreas, Wang, Jianxiang, Kim, Dong-Wook, Kim, Dennis Dong Hwan, Mayer, Jiri, Goh, Yeow-Tee, le Coutre, Philipp, Takahashi, Naoto, Kim, Inho, Etienne, Gabriel, Andorsky, David, Issa, Ghayas C., Larson, Richard A., Bombaci, Felice, Kapoor, Shruti, McCulloch, Tracey, Malek, Kamel, Yau, Lillian, Ifrah, Sophie, Hoch, Matthias, Cortes, Jorge E., Hughes, Timothy P.
Published in The New England journal of medicine (12.09.2024)
Published in The New England journal of medicine (12.09.2024)
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Journal Article
Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia
Hughes, Timothy P., Laneuville, Pierre, Rousselot, Philippe, Snyder, David S., Rea, Delphine, Shah, Neil P., Paar, David, Abruzzese, Elisabetta, Hochhaus, Andreas, Lipton, Jeffrey H., Cortes, Jorge E.
Published in Haematologica (Roma) (01.01.2019)
Published in Haematologica (Roma) (01.01.2019)
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Journal Article
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)
Hughes, Timothy P., Hochhaus, Andreas, Branford, Susan, Müller, Martin C., Kaeda, Jaspal S., Foroni, Letizia, Druker, Brian J., Guilhot, François, Larson, Richard A., O'Brien, Stephen G., Rudoltz, Marc S., Mone, Manisha, Wehrle, Elisabeth, Modur, Vijay, Goldman, John M., Radich, Jerald P.
Published in Blood (11.11.2010)
Published in Blood (11.11.2010)
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Journal Article
Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
Kantarjian, Hagop M, Hochhaus, Andreas, Saglio, Giuseppe, Souza, Carmino De, Flinn, Ian W, Stenke, Leif, Goh, Yeow-Tee, Rosti, Gianantonio, Nakamae, Hirohisa, Gallagher, Neil J, Hoenekopp, Albert, Blakesley, Rick E, Larson, Richard A, Hughes, Timothy P
Published in The lancet oncology (01.09.2011)
Published in The lancet oncology (01.09.2011)
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Journal Article
Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations
Müller, Martin C., Cortes, Jorge E., Kim, Dong-Wook, Druker, Brian J., Erben, Philipp, Pasquini, Ricardo, Branford, Susan, Hughes, Timothy P., Radich, Jerald P., Ploughman, Lynn, Mukhopadhyay, Jaydip, Hochhaus, Andreas
Published in Blood (03.12.2009)
Published in Blood (03.12.2009)
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Journal Article
Chronic myeloid leukemia: reminiscences and dreams
Mughal, T. I., Radich, J. P., Deininger, M. W., Apperley, J. F., Hughes, T. P., Harrison, C. J., Gambacorti-Passerini, C., Saglio, G., Cortes, J., Daley, G. Q.
Published in Haematologica (Roma) (01.05.2016)
Published in Haematologica (Roma) (01.05.2016)
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Journal Article
Impact of additional genetic abnormalities at diagnosis of chronic myeloid leukemia for first-line imatinib-treated patients receiving proactive treatment intervention
Shanmuganathan, Naranie, Wadham, Carol, Shahrin, NurHezrin, Feng, Jinghua, Thomson, Daniel, Wang, Paul, Saunders, Verity, Kok, Chung Hoow, King, Rob M., Kenyon, Rosalie R., Lin, Ming, Pagani, Ilaria S., Ross, David M., Yong, Agnes S.M., Grigg, Andrew P., Mills, Anthony K., Schwarer, Anthony P., Braley, Jodi, Altamura, Haley, Yeung, David T., Scott, Hamish S., Schreiber, Andreas W., Hughes, Timothy P., Branford, Susan
Published in Haematologica (Roma) (01.09.2023)
Published in Haematologica (Roma) (01.09.2023)
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Journal Article
Functional Activity of the OCT-1 Protein Is Predictive of Long-Term Outcome in Patients With Chronic-Phase Chronic Myeloid Leukemia Treated With Imatinib
White, Deborah L., Dang, Phuong, Engler, Jane, Frede, Amity, Zrim, Stephanie, Osborn, Michael, Saunders, Verity A., Manley, Paul W., Hughes, Timothy P.
Published in Journal of clinical oncology (01.06.2010)
Published in Journal of clinical oncology (01.06.2010)
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Journal Article