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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Gilbert, Luke A., Horlbeck, Max A., Adamson, Britt, Villalta, Jacqueline E., Chen, Yuwen, Whitehead, Evan H., Guimaraes, Carla, Panning, Barbara, Ploegh, Hidde L., Bassik, Michael C., Qi, Lei S., Kampmann, Martin, Weissman, Jonathan S.
Published in Cell (23.10.2014)
Published in Cell (23.10.2014)
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Journal Article
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
Norman, Thomas M., Horlbeck, Max A., Replogle, Joseph M., Ge, Alex Y., Xu, Albert, Jost, Marco, Gilbert, Luke A., Weissman, Jonathan S.
Published in Science (American Association for the Advancement of Science) (23.08.2019)
Published in Science (American Association for the Advancement of Science) (23.08.2019)
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Journal Article
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
Bassik, Michael C., Kampmann, Martin, Lebbink, Robert Jan, Wang, Shuyi, Hein, Marco Y., Poser, Ina, Weibezahn, Jimena, Horlbeck, Max A., Chen, Siyuan, Mann, Matthias, Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.
Published in Cell (14.02.2013)
Published in Cell (14.02.2013)
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Journal Article
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
Adamson, Britt, Norman, Thomas M., Jost, Marco, Cho, Min Y., Nuñez, James K., Chen, Yuwen, Villalta, Jacqueline E., Gilbert, Luke A., Horlbeck, Max A., Hein, Marco Y., Pak, Ryan A., Gray, Andrew N., Gross, Carol A., Dixit, Atray, Parnas, Oren, Regev, Aviv, Weissman, Jonathan S.
Published in Cell (15.12.2016)
Published in Cell (15.12.2016)
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Journal Article
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
Horlbeck, Max A, Gilbert, Luke A, Villalta, Jacqueline E, Adamson, Britt, Pak, Ryan A, Chen, Yuwen, Fields, Alexander P, Park, Chong Yon, Corn, Jacob E, Kampmann, Martin, Weissman, Jonathan S
Published in eLife (23.09.2016)
Published in eLife (23.09.2016)
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Journal Article
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
Liu, S. John, Horlbeck, Max A., Cho, Seung Woo, Birk, Harjus S., Malatesta, Martina, He, Daniel, Attenello, Frank J., Villalta, Jacqueline E., Cho, Min Y., Chen, Yuwen, Mandegar, Mohammad A., Olvera, Michael P., Gilbert, Luke A., Conklin, Bruce R., Chang, Howard Y., Weissman, Jonathan S., Lim, Daniel A.
Published in Science (American Association for the Advancement of Science) (06.01.2017)
Published in Science (American Association for the Advancement of Science) (06.01.2017)
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Journal Article
Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
Cho, Seung Woo, Xu, Jin, Sun, Ruping, Mumbach, Maxwell R., Carter, Ava C., Chen, Y. Grace, Yost, Kathryn E., Kim, Jeewon, He, Jing, Nevins, Stephanie A., Chin, Suet-Feung, Caldas, Carlos, Liu, S. John, Horlbeck, Max A., Lim, Daniel A., Weissman, Jonathan S., Curtis, Christina, Chang, Howard Y.
Published in Cell (31.05.2018)
Published in Cell (31.05.2018)
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Journal Article
Mapping the Genetic Landscape of Human Cells
Horlbeck, Max A., Xu, Albert, Wang, Min, Bennett, Neal K., Park, Chong Y., Bogdanoff, Derek, Adamson, Britt, Chow, Eric D., Kampmann, Martin, Peterson, Tim R., Nakamura, Ken, Fischbach, Michael A., Weissman, Jonathan S., Gilbert, Luke A.
Published in Cell (09.08.2018)
Published in Cell (09.08.2018)
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Journal Article
Single-cell analysis of long non-coding RNAs in the developing human neocortex
Liu, Siyuan John, Nowakowski, Tomasz J., Pollen, Alex A., Lui, Jan H., Horlbeck, Max A., Attenello, Frank J., He, Daniel, Weissman, Jonathan S., Kriegstein, Arnold R., Diaz, Aaron A., Lim, Daniel A.
Published in Genome Biology (14.04.2016)
Published in Genome Biology (14.04.2016)
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Journal Article
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
Jost, Marco, Santos, Daniel A., Saunders, Reuben A., Horlbeck, Max A., Hawkins, John S., Scaria, Sonia M., Norman, Thomas M., Hussmann, Jeffrey A., Liem, Christina R., Gross, Carol A., Weissman, Jonathan S.
Published in Nature biotechnology (01.03.2020)
Published in Nature biotechnology (01.03.2020)
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Journal Article
High-content imaging-based pooled CRISPR screens in mammalian cells
Yan, Xiaowei, Stuurman, Nico, Ribeiro, Susana A., Tanenbaum, Marvin E., Horlbeck, Max A., Liem, Christina R., Jost, Marco, Weissman, Jonathan S., Vale, Ronald D.
Published in The Journal of cell biology (01.02.2021)
Published in The Journal of cell biology (01.02.2021)
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Journal Article
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
Horlbeck, Max A, Witkowsky, Lea B, Guglielmi, Benjamin, Replogle, Joseph M, Gilbert, Luke A, Villalta, Jacqueline E, Torigoe, Sharon E, Tjian, Robert, Weissman, Jonathan S
Published in eLife (17.03.2016)
Published in eLife (17.03.2016)
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Journal Article
CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
Mandegar, Mohammad A., Huebsch, Nathaniel, Frolov, Ekaterina B., Shin, Edward, Truong, Annie, Olvera, Michael P., Chan, Amanda H., Miyaoka, Yuichiro, Holmes, Kristin, Spencer, C. Ian, Judge, Luke M., Gordon, David E., Eskildsen, Tilde V., Villalta, Jacqueline E., Horlbeck, Max A., Gilbert, Luke A., Krogan, Nevan J., Sheikh, Søren P., Weissman, Jonathan S., Qi, Lei S., So, Po-Lin, Conklin, Bruce R.
Published in Cell stem cell (07.04.2016)
Published in Cell stem cell (07.04.2016)
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Journal Article
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
Liu, S. John, Malatesta, Martina, Lien, Brian V., Saha, Parna, Thombare, Shivani S., Hong, Sung Jun, Pedraza, Leslie, Koontz, Mark, Seo, Kyounghee, Horlbeck, Max A., He, Daniel, Birk, Harjus S., Jain, Miten, Olsen, Hugh E., Akeson, Mark, Weissman, Jonathan S., Monje, Michelle, Gupta, Nalin, Raleigh, David R., Ullian, Erik M., Lim, Daniel A.
Published in Genome Biology (31.03.2020)
Published in Genome Biology (31.03.2020)
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Journal Article
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
Deans, Richard M, Morgens, David W, Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A, Kampmann, Martin, Gilbert, Luke A, Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S, Carette, Jan E, Khosla, Chaitan, Bassik, Michael C
Published in Nature chemical biology (01.05.2016)
Published in Nature chemical biology (01.05.2016)
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Journal Article
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
Braun, Christian J., Bruno, Peter M., Horlbeck, Max A., Gilbert, Luke A., Weissman, Jonathan S., Hemann, Michael T.
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2016)
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Journal Article
Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes
Horlbeck, Max A., Liu, S. John, Chang, Howard Y., Lim, Daniel A., Weissman, Jonathan S.
Published in Nature biotechnology (01.05.2020)
Published in Nature biotechnology (01.05.2020)
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Journal Article
Cellular response to small molecules that selectively stall protein synthesis by the ribosome
Liaud, Nadège, Horlbeck, Max A., Gilbert, Luke A., Gjoni, Ketrin, Weissman, Jonathan S., Cate, Jamie H. D.
Published in PLoS genetics (15.03.2019)
Published in PLoS genetics (15.03.2019)
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Journal Article
Next-generation libraries for robust RNA interference-based genome-wide screens
Kampmann, Martin, Max A. Horlbeck, Yuwen Chen, Jordan C. Tsai, Michael C. Bassik, Luke A. Gilbert, Jacqueline E. Villalta, S. Chul Kwon, Hyeshik Chang, V. Narry Kim, Jonathan S. Weissman
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2015)
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Journal Article
A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure
Mendelsohn, Bryce A., Bennett, Neal K., Darch, Maxwell A., Yu, Katharine, Nguyen, Mai K., Pucciarelli, Daniela, Nelson, Maxine, Horlbeck, Max A., Gilbert, Luke A., Hyun, William, Kampmann, Martin, Nakamura, Jean L., Nakamura, Ken
Published in PLoS biology (27.08.2018)
Published in PLoS biology (27.08.2018)
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Journal Article