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Reversible modulation of circadian time with chronophotopharmacology
Kolarski, Dušan, Miró-Vinyals, Carla, Sugiyama, Akiko, Srivastava, Ashutosh, Ono, Daisuke, Nagai, Yoshiko, Iida, Mui, Itami, Kenichiro, Tama, Florence, Szymanski, Wiktor, Hirota, Tsuyoshi, Feringa, Ben L.
Published in Nature communications (26.05.2021)
Published in Nature communications (26.05.2021)
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Journal Article
Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation
Miller, Simon, Srivastava, Ashutosh, Nagai, Yoshiko, Aikawa, Yoshiki, Tama, Florence, Hirota, Tsuyoshi
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2021)
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Journal Article
Isoform-selective regulation of mammalian cryptochromes
Miller, Simon, Son, You Lee, Aikawa, Yoshiki, Makino, Eri, Nagai, Yoshiko, Srivastava, Ashutosh, Oshima, Tsuyoshi, Sugiyama, Akiko, Hara, Aya, Abe, Kazuhiro, Hirata, Kunio, Oishi, Shinya, Hagihara, Shinya, Sato, Ayato, Tama, Florence, Itami, Kenichiro, Kay, Steve A., Hatori, Megumi, Hirota, Tsuyoshi
Published in Nature chemical biology (01.06.2020)
Published in Nature chemical biology (01.06.2020)
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Journal Article
Identification of Small Molecule Activators of Cryptochrome
Hirota, Tsuyoshi, Lee, Jae Wook, St. John, Peter C., Sawa, Mariko, Iwaisako, Keiko, Noguchi, Takako, Pongsawakul, Pagkapol Y., Sonntag, Tim, Welsh, David K., Brenner, David A., Doyle, Francis J., Schultz, Peter G., Kay, Steve A.
Published in Science (American Association for the Advancement of Science) (31.08.2012)
Published in Science (American Association for the Advancement of Science) (31.08.2012)
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Journal Article
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Zhang, Eric E, Liu, Yi, Dentin, Renaud, Pongsawakul, Pagkapol Y, Liu, Andrew C, Hirota, Tsuyoshi, Nusinow, Dmitri A, Sun, Xiujie, Landais, Severine, Kodama, Yuzo, Brenner, David A, Montminy, Marc, Kay, Steve A
Published in Nature medicine (01.10.2010)
Published in Nature medicine (01.10.2010)
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Journal Article
DYRK1A and Glycogen Synthase Kinase 3β, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping
Kurabayashi, Nobuhiro, Hirota, Tsuyoshi, Sakai, Mihoko, Sanada, Kamon, Fukada, Yoshitaka
Published in Molecular and Cellular Biology (01.04.2010)
Published in Molecular and Cellular Biology (01.04.2010)
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Journal Article
Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing
Fribourgh, Jennifer L, Srivastava, Ashutosh, Sandate, Colby R, Michael, Alicia K, Hsu, Peter L, Rakers, Christin, Nguyen, Leslee T, Torgrimson, Megan R, Parico, Gian Carlo G, Tripathi, Sarvind, Zheng, Ning, Lander, Gabriel C, Hirota, Tsuyoshi, Tama, Florence, Partch, Carrie L
Published in eLife (26.02.2020)
Published in eLife (26.02.2020)
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Journal Article
Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Kolarski, Dušan, Miller, Simon, Oshima, Tsuyoshi, Nagai, Yoshiko, Aoki, Yugo, Kobauri, Piermichele, Srivastava, Ashutosh, Sugiyama, Akiko, Amaike, Kazuma, Sato, Ayato, Tama, Florence, Szymanski, Wiktor, Feringa, Ben L, Itami, Kenichiro, Hirota, Tsuyoshi
Published in Journal of the American Chemical Society (03.02.2021)
Published in Journal of the American Chemical Society (03.02.2021)
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Journal Article
“Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms
D'Amore, Claudio, Moro, Enrico, Borgo, Christian, Itami, Kenichiro, Hirota, Tsuyoshi, Pinna, Lorenzo A., Salvi, Mauro
Published in Biochimica et biophysica acta. Molecular cell research (01.11.2020)
Published in Biochimica et biophysica acta. Molecular cell research (01.11.2020)
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Journal Article
chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β
Hirota, Tsuyoshi, Lewis, Warren G, Liu, Andrew C, Lee, Jae Wook, Schultz, Peter G, Kay, Steve A
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2008)
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Journal Article
Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine
Zhang, Manhui, Kobayashi, Kohei, Atsumi, Haruki, Katada, Yuma, Nakane, Yusuke, Chen, Junfeng, Nagano, Ryo, Kadofusa, Naoya, Nishiwaki-Ohkawa, Taeko, Kon, Naohiro, Hirota, Tsuyoshi, Sato, Ayato, Makino, Toshiaki, Yoshimura, Takashi
Published in Scientific reports (26.10.2021)
Published in Scientific reports (26.10.2021)
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Journal Article
High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase
Hirota, Tsuyoshi, Lee, Jae Wook, Lewis, Warren G., Zhang, Eric E., Breton, Ghislain, Liu, Xianzhong, Garcia, Michael, Peters, Eric C., Etchegaray, Jean-Pierre, Traver, David, Schultz, Peter G., Kay, Steve A.
Published in PLoS biology (01.12.2010)
Published in PLoS biology (01.12.2010)
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Journal Article
A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Zhang, Eric E., Liu, Andrew C., Hirota, Tsuyoshi, Miraglia, Loren J., Welch, Genevieve, Pongsawakul, Pagkapol Y., Liu, Xianzhong, Atwood, Ann, Huss, Jon W., Janes, Jeff, Su, Andrew I., Hogenesch, John B., Kay, Steve A.
Published in Cell (02.10.2009)
Published in Cell (02.10.2009)
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Journal Article
Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach
Borgo, Christian, Cesaro, Luca, Hirota, Tsuyoshi, Kuwata, Keiko, D’Amore, Claudio, Ruppert, Thomas, Blatnik, Renata, Salvi, Mauro, Pinna, Lorenzo A.
Published in European journal of medicinal chemistry (15.03.2021)
Published in European journal of medicinal chemistry (15.03.2021)
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Journal Article
Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period
Uehara, Takahiro N, Nonoyama, Takashi, Taki, Kyomi, Kuwata, Keiko, Sato, Ayato, Fujimoto, Kazuhiro J, Hirota, Tsuyoshi, Matsuo, Hiromi, Maeda, Akari E, Ono, Azusa, Takahara, Tomoaki T, Tsutsui, Hiroki, Suzuki, Takamasa, Yanai, Takeshi, Kay, Steve A, Itami, Kenichiro, Kinoshita, Toshinori, Yamaguchi, Junichiro, Nakamichi, Norihito
Published in Plant and cell physiology (19.04.2022)
Published in Plant and cell physiology (19.04.2022)
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Journal Article
Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
Oshima, Tsuyoshi, Niwa, Yoshimi, Kuwata, Keiko, Srivastava, Ashutosh, Hyoda, Tomoko, Tsuchiya, Yoshiki, Kumagai, Megumi, Tsuyuguchi, Masato, Tamaru, Teruya, Sugiyama, Akiko, Ono, Natsuko, Zolboot, Norjin, Aikawa, Yoshiki, Oishi, Shunsuke, Nonami, Atsushi, Arai, Fumio, Hagihara, Shinya, Yamaguchi, Junichiro, Tama, Florence, Kunisaki, Yuya, Yagita, Kazuhiro, Ikeda, Masaaki, Kinoshita, Takayoshi, Kay, Steve A., Itami, Kenichiro, Hirota, Tsuyoshi
Published in Science advances (01.01.2019)
Published in Science advances (01.01.2019)
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Journal Article
A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins [version 1; peer review: 2 approved]
Yagi, Moeri, Miller, Simon, Nagai, Yoshiko, Inuki, Shinsuke, Sato, Ayato, Hirota, Tsuyoshi
Published in F1000 research (01.01.2022)
Published in F1000 research (01.01.2022)
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Journal Article