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Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau
Rayaprolu, Sruti, Higginbotham, Lenora, Bagchi, Pritha, Watson, Caroline M., Zhang, Tian, Levey, Allan I., Rangaraju, Srikant, Seyfried, Nicholas T.
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2021)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2021)
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Journal Article
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Johnson, Erik C. B., Dammer, Eric B., Duong, Duc M., Ping, Lingyan, Zhou, Maotian, Yin, Luming, Higginbotham, Lenora A., Guajardo, Andrew, White, Bartholomew, Troncoso, Juan C., Thambisetty, Madhav, Montine, Thomas J., Lee, Edward B., Trojanowski, John Q., Beach, Thomas G., Reiman, Eric M., Haroutunian, Vahram, Wang, Minghui, Schadt, Eric, Zhang, Bin, Dickson, Dennis W., Ertekin-Taner, Nilüfer, Golde, Todd E., Petyuk, Vladislav A., De Jager, Philip L., Bennett, David A., Wingo, Thomas S., Rangaraju, Srikant, Hajjar, Ihab, Shulman, Joshua M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Nature medicine (01.05.2020)
Published in Nature medicine (01.05.2020)
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Journal Article
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
Higginbotham, Lenora, Ping, Lingyan, Dammer, Eric B., Duong, Duc M., Zhou, Maotian, Gearing, Marla, Hurst, Cheyenne, Glass, Jonathan D., Factor, Stewart A., Johnson, Erik C. B., Hajjar, Ihab, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Science advances (01.10.2020)
Published in Science advances (01.10.2020)
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Journal Article
Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-β Production in an Alzheimer's Disease Mouse Model
Herskowitz, Jeremy H., Feng, Yangbo, Mattheyses, Alexa L., Hales, Chadwick M., Higginbotham, Lenora A., Duong, Duc M., Montine, Thomas J., Troncoso, Juan C., Thambisetty, Madhav, Seyfried, Nicholas T., Levey, Allan I., Lah, James J.
Published in The Journal of neuroscience (04.12.2013)
Published in The Journal of neuroscience (04.12.2013)
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Journal Article
Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment
Higginbotham, Lenora, Carter, E. Kathleen, Dammer, Eric B., Haque, Rafi U., Johnson, Erik C.B., Duong, Duc M., Yin, Luming, De Jager, Philip L., Bennett, David A., Felsky, Daniel, Tio, Earvin S., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Neurobiology of disease (01.10.2023)
Published in Neurobiology of disease (01.10.2023)
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Journal Article
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Shantaraman, Anantharaman, Dammer, Eric B., Ugochukwu, Obiadada, Duong, Duc M., Yin, Luming, Carter, E. Kathleen, Gearing, Marla, Chen-Plotkin, Alice, Lee, Edward B., Trojanowski, John Q., Bennett, David A., Lah, James J., Levey, Allan I., Seyfried, Nicholas T., Higginbotham, Lenora
Published in Molecular neurodegeneration (06.08.2024)
Published in Molecular neurodegeneration (06.08.2024)
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Journal Article
Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Shantaraman, Anantharaman, Dammer, Eric B., Ugochukwu, Obiadada, Duong, Duc M., Yin, Luming, Carter, E. Kathleen, Gearing, Marla, Chen-Plotkin, Alice, Lee, Edward B., Trojanowski, John Q., Bennett, David A., Lah, James J., Levey, Allan I., Seyfried, Nicholas T., Higginbotham, Lenora
Published in Molecular neurodegeneration (11.10.2024)
Published in Molecular neurodegeneration (11.10.2024)
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Journal Article
Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
Higginbotham, Lenora, Dammer, Eric, Duong, Duc, Modeste, Erica, Montine, Thomas, Lah, James, Levey, Allan, Seyfried, Nicholas
Published in Proteomes (27.08.2019)
Published in Proteomes (27.08.2019)
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Journal Article
A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
Levey, Allan I, Qiu, Deqiang, Zhao, Liping, Hu, William T, Duong, Duc M, Higginbotham, Lenora, Dammer, Eric B, Seyfried, Nicholas T, Wingo, Thomas S, Hales, Chadwick M, Gámez Tansey, Malú, Goldstein, David S, Abrol, Anees, Calhoun, Vince D, Goldstein, Felicia C, Hajjar, Ihab, Fagan, Anne M, Galasko, Doug, Edland, Steven D, Hanfelt, John, Lah, James J, Weinshenker, David
Published in Brain (London, England : 1878) (30.06.2022)
Published in Brain (London, England : 1878) (30.06.2022)
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Journal Article
Unbiased Classification of the Human Brain Proteome Resolves Distinct Clinical and Pathophysiological Subtypes of Cognitive Impairment
Higginbotham, Lenora A, Carter, E Kathleen, Dammer, Eric B, Haque, Rafi U, Johnson, Erik Cb, Duong, Duc, Yin, Luming, De Jager, Phillip L, Bennett, David A, Lah, James J, Levey, Allan I, Seyfried, Nicholas T
Published in bioRxiv (25.07.2022)
Published in bioRxiv (25.07.2022)
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Paper
Proteomics identifies CSF biomarker panels reflective of pathological networks in the Alzheimer's disease brain
Higginbotham, Lenora A, Ping, Lingyan, Dammer, Eric B, Duong, Duc, Zhou, Maotian, Gearing, Marla, Johnson, Erik CB, Hajjar, Ihab, Lah, James J, Levey, Allan I, Seyfried, Nicholas T
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Proteomics identifies CSF biomarker panels reflective of pathological networks in the Alzheimer's disease brain: Biomarkers (non‐neuroimaging): Novel biomarkers
Higginbotham, Lenora A, Ping, Lingyan, Dammer, Eric B, Duong, Duc, Zhou, Maotian, Gearing, Marla, Johnson, Erik CB, Hajjar, Ihab, Lah, James J, Levey, Allan I, Seyfried, Nicholas T
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
INTEGRATIVE PROTEOMICS LINKS CEREBROSPINAL FLUID BIOMARKERS TO PATHOLOGICAL NETWORKS IN THE ALZHEIMER’S DISEASE BRAIN
Ping, Lingyan, Higginbotham, Lenora A., Dammer, Eric B., Duong, Duc, Zhou, Maotian, Wingo, Thomas S., Johnson, Erik C.B., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
O1‐01‐01: INTEGRATIVE PROTEOMICS LINKS CEREBROSPINAL FLUID BIOMARKERS TO PATHOLOGICAL NETWORKS IN THE ALZHEIMER'S DISEASE BRAIN
Ping, Lingyan, Higginbotham, Lenora A., Dammer, Eric B., Duong, Duc, Zhou, Maotian, Wingo, Thomas S., Johnson, Erik C.B., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
Patients with Cognitive Impairment in Parkinson's Disease Benefit from Deep Brain Stimulation: A Case‐Control Study
Block, Cady K., Patel, Margi, Risk, Benjamin B., Staikova, Ekaterina, Loring, David, Esper, Christine D., Scorr, Laura, Higginbotham, Lenora, Aia, Pratibha, DeLong, Mahlon R., Wichmann, Thomas, Factor, Stewart A., Au Yong, Nicholas, Willie, Jon T., Boulis, Nicholas M., Gross, Robert E., Buetefisch, Cathrin, Miocinovic, Svjetlana
Published in Movement disorders clinical practice (Hoboken, N.J.) (01.03.2023)
Published in Movement disorders clinical practice (Hoboken, N.J.) (01.03.2023)
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Journal Article
A consensus proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Johnson, Erik C.B., Dammer, Eric B., Duong, Duc, Ping, Lingyan, Zhou, Maotian, Yin, Luming, Higginbotham, Lenora A., Guajardo, Andrew, White, Bartholomew, Troncoso, Juan C., Thambisetty, Madhav, Montine, Thomas J., Lee, Eddie B., Trojanowski, John Q., Beach, Thomas G., Reiman, Eric M., Haroutunian, Vahram, Wang, Minghui, Schadt, Eric, Zhang, Bin, Dickson, Dennis W., Ertekin‐Taner, Nilufer, Golde, Todd E., Petyuk, Vladislav A., Jager, Philip L., Bennett, David A., Wingo, Thomas S., Rangaraju, Srikant, Hajjar, Ihab, Shulman, Joshua M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
A consensus proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation: Molecular and cell biology/others
Johnson, Erik C.B., Dammer, Eric B., Duong, Duc, Ping, Lingyan, Zhou, Maotian, Yin, Luming, Higginbotham, Lenora A., Guajardo, Andrew, White, Bartholomew, Troncoso, Juan C., Thambisetty, Madhav, Montine, Thomas J., Lee, Eddie B., Trojanowski, John Q., Beach, Thomas G., Reiman, Eric M., Haroutunian, Vahram, Wang, Minghui, Schadt, Eric, Zhang, Bin, Dickson, Dennis W., Ertekin‐Taner, Nilufer, Golde, Todd E., Petyuk, Vladislav A., Jager, Philip L., Bennett, David A., Wingo, Thomas S., Rangaraju, Srikant, Hajjar, Ihab, Shulman, Joshua M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article