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The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases
Todd, Alison C., Hardingham, Giles E.
Published in International journal of molecular sciences (17.12.2020)
Published in International journal of molecular sciences (17.12.2020)
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Journal Article
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
Rojo, Rocío, Raper, Anna, Ozdemir, Derya D., Lefevre, Lucas, Grabert, Kathleen, Wollscheid-Lengeling, Evi, Bradford, Barry, Caruso, Melanie, Gazova, Iveta, Sánchez, Alejandra, Lisowski, Zofia M., Alves, Joana, Molina-Gonzalez, Irene, Davtyan, Hayk, Lodge, Rebecca J., Glover, James D., Wallace, Robert, Munro, David A. D., David, Eyal, Amit, Ido, Miron, Véronique E., Priller, Josef, Jenkins, Stephen J., Hardingham, Giles E., Blurton-Jones, Mathew, Mabbott, Neil A., Summers, Kim M., Hohenstein, Peter, Hume, David A., Pridans, Clare
Published in Nature communications (19.07.2019)
Published in Nature communications (19.07.2019)
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Journal Article
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
Mehta, Arpan R., Gregory, Jenna M., Dando, Owen, Carter, Roderick N., Burr, Karen, Nanda, Jyoti, Story, David, McDade, Karina, Smith, Colin, Morton, Nicholas M., Mahad, Don J., Hardingham, Giles E., Chandran, Siddharthan, Selvaraj, Bhuvaneish T.
Published in Acta neuropathologica (01.02.2021)
Published in Acta neuropathologica (01.02.2021)
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Journal Article
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Molina-Gonzalez, Irene, Holloway, Rebecca K., Jiwaji, Zoeb, Dando, Owen, Kent, Sarah A., Emelianova, Katie, Lloyd, Amy F., Forbes, Lindsey H., Mahmood, Ayisha, Skripuletz, Thomas, Gudi, Viktoria, Febery, James A., Johnson, Jeffrey A., Fowler, Jill H., Kuhlmann, Tanja, Williams, Anna, Chandran, Siddharthan, Stangel, Martin, Howden, Andrew J. M., Hardingham, Giles E., Miron, Veronique E.
Published in Nature communications (08.06.2023)
Published in Nature communications (08.06.2023)
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Journal Article
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
Jiwaji, Zoeb, Tiwari, Sachin S., Avilés-Reyes, Rolando X., Hooley, Monique, Hampton, David, Torvell, Megan, Johnson, Delinda A., McQueen, Jamie, Baxter, Paul, Sabari-Sankar, Kayalvizhi, Qiu, Jing, He, Xin, Fowler, Jill, Febery, James, Gregory, Jenna, Rose, Jamie, Tulloch, Jane, Loan, Jamie, Story, David, McDade, Karina, Smith, Amy M., Greer, Peta, Ball, Matthew, Kind, Peter C., Matthews, Paul M., Smith, Colin, Dando, Owen, Spires-Jones, Tara L., Johnson, Jeffrey A., Chandran, Siddharthan, Hardingham, Giles E.
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., McQueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.
Published in Nature communications (02.05.2017)
Published in Nature communications (02.05.2017)
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Journal Article
Lineage divergence of activity-driven transcription and evolution of cognitive ability
Hardingham, Giles E, Pruunsild, Priit, Greenberg, Michael E, Bading, Hilmar
Published in Nature reviews. Neuroscience (01.01.2018)
Published in Nature reviews. Neuroscience (01.01.2018)
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Journal Article
Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
Zhao, Chen, Devlin, Anna‐Claire, Chouhan, Amit K., Selvaraj, Bhuvaneish T., Stavrou, Maria, Burr, Karen, Brivio, Veronica, He, Xin, Mehta, Arpan R., Story, David, Shaw, Christopher E., Dando, Owen, Hardingham, Giles E., Miles, Gareth B., Chandran, Siddharthan
Published in Glia (01.05.2020)
Published in Glia (01.05.2020)
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Journal Article
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment
Sigfridsson, Emma, Marangoni, Martina, Hardingham, Giles E., Horsburgh, Karen, Fowler, Jill H.
Published in Journal of neuroinflammation (01.12.2020)
Published in Journal of neuroinflammation (01.12.2020)
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Journal Article
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease
Pickett, Eleanor K., Herrmann, Abigail G., McQueen, Jamie, Abt, Kimberly, Dando, Owen, Tulloch, Jane, Jain, Pooja, Dunnett, Sophie, Sohrabi, Sadaf, Fjeldstad, Maria P., Calkin, Will, Murison, Leo, Jackson, Rosemary J., Tzioras, Makis, Stevenson, Anna, d’Orange, Marie, Hooley, Monique, Davies, Caitlin, Colom-Cadena, Marti, Anton-Fernandez, Alejandro, King, Declan, Oren, Iris, Rose, Jamie, McKenzie, Chris-Anne, Allison, Elizabeth, Smith, Colin, Hardt, Oliver, Henstridge, Christopher M., Hardingham, Giles E., Spires-Jones, Tara L.
Published in Cell reports (Cambridge) (10.12.2019)
Published in Cell reports (Cambridge) (10.12.2019)
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Journal Article
The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults
Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.
Published in Neuron (Cambridge, Mass.) (10.05.2012)
Published in Neuron (Cambridge, Mass.) (10.05.2012)
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Journal Article
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
Qiu, Jing, Tan, Yan-Wei, Hagenston, Anna M., Martel, Marc-Andre, Kneisel, Niclas, Skehel, Paul A., Wyllie, David J. A., Bading, Hilmar, Hardingham, Giles E.
Published in Nature communications (18.06.2013)
Published in Nature communications (18.06.2013)
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Journal Article
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
Selvaraj, Bhuvaneish T., Livesey, Matthew R., Zhao, Chen, Gregory, Jenna M., James, Owain T., Cleary, Elaine M., Chouhan, Amit K., Gane, Angus B., Perkins, Emma M., Dando, Owen, Lillico, Simon G., Lee, Youn-Bok, Nishimura, Agnes L., Poreci, Urjana, Thankamony, Sai, Pray, Meryll, Vasistha, Navneet A., Magnani, Dario, Borooah, Shyamanga, Burr, Karen, Story, David, McCampbell, Alexander, Shaw, Christopher E., Kind, Peter C., Aitman, Timothy J., Whitelaw, C. Bruce A., Wilmut, Ian, Smith, Colin, Miles, Gareth B., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan
Published in Nature communications (24.01.2018)
Published in Nature communications (24.01.2018)
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Journal Article
Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators
Fowler, Jill H, McQueen, Jamie, Holland, Philip R, Manso, Yasmina, Marangoni, Martina, Scott, Fiona, Chisholm, Emma, Scannevin, Robert H, Hardingham, Giles E, Horsburgh, Karen
Published in Journal of cerebral blood flow and metabolism (01.08.2018)
Published in Journal of cerebral blood flow and metabolism (01.08.2018)
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Journal Article
Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system
Baxter, Paul S., Bell, Karen F.S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.
Published in Nature communications (09.04.2015)
Published in Nature communications (09.04.2015)
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Journal Article
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Bilican, Bilada, Serio, Andrea, Barmada, Sami J, Nishimura, Agnes Lumi, Sullivan, Gareth J, Carrasco, Monica, Phatnani, Hemali P, Puddifoot, Clare A, Story, David, Fletcher, Judy, Park, In-Hyun, Friedman, Brad A, Daley, George Q, Wyllie, David J. A, Hardingham, Giles E, Wilmut, Ian, Finkbeiner, Steven, Maniatis, Tom, Shaw, Christopher E, Chandran, Siddharthan
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
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Journal Article