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Microglia in Alzheimer’s disease
Hansen, David V., Hanson, Jesse E., Sheng, Morgan
Published in The Journal of cell biology (05.02.2018)
Published in The Journal of cell biology (05.02.2018)
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Journal Article
TREM2, Microglia, and Neurodegenerative Diseases
Yeh, Felix L., Hansen, David V., Sheng, Morgan
Published in Trends in molecular medicine (01.06.2017)
Published in Trends in molecular medicine (01.06.2017)
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Journal Article
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J., Stark, Kimberly L., Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A., Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V.
Published in The Journal of neuroscience (26.02.2020)
Published in The Journal of neuroscience (26.02.2020)
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Journal Article
Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
Srinivasan, Karpagam, Friedman, Brad A., Etxeberria, Ainhoa, Huntley, Melanie A., van der Brug, Marcel P., Foreman, Oded, Paw, Jonathan S., Modrusan, Zora, Beach, Thomas G., Serrano, Geidy E., Hansen, David V.
Published in Cell reports (Cambridge) (30.06.2020)
Published in Cell reports (Cambridge) (30.06.2020)
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Journal Article
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L., Kaminker, Joshua S., van der Brug, Marcel P., Hansen, David V.
Published in Cell reports (Cambridge) (16.01.2018)
Published in Cell reports (Cambridge) (16.01.2018)
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Journal Article
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
Wu, Tiffany, Dejanovic, Borislav, Gandham, Vineela D., Gogineni, Alvin, Edmonds, Rose, Schauer, Stephen, Srinivasan, Karpagam, Huntley, Melanie A., Wang, Yuanyuan, Wang, Tzu-Ming, Hedehus, Maj, Barck, Kai H., Stark, Maya, Ngu, Hai, Foreman, Oded, Meilandt, William J., Elstrott, Justin, Chang, Michael C., Hansen, David V., Carano, Richard A.D., Sheng, Morgan, Hanson, Jesse E.
Published in Cell reports (Cambridge) (20.08.2019)
Published in Cell reports (Cambridge) (20.08.2019)
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Journal Article
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, David V., Lui, Jan H., Parker, Philip R. L., Kriegstein, Arnold R.
Published in Nature (London) (25.03.2010)
Published in Nature (London) (25.03.2010)
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Journal Article
Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
Srinivasan, Karpagam, Friedman, Brad A., Larson, Jessica L., Lauffer, Benjamin E., Goldstein, Leonard D., Appling, Laurie L., Borneo, Jovencio, Poon, Chungkee, Ho, Terence, Cai, Fang, Steiner, Pascal, van der Brug, Marcel P., Modrusan, Zora, Kaminker, Joshua S., Hansen, David V.
Published in Nature communications (21.04.2016)
Published in Nature communications (21.04.2016)
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Journal Article
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Hansen, David V, Lui, Jan H, Flandin, Pierre, Yoshikawa, Kazuaki, Rubenstein, John L, Alvarez-Buylla, Arturo, Kriegstein, Arnold R
Published in Nature neuroscience (01.11.2013)
Published in Nature neuroscience (01.11.2013)
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Journal Article
Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
Chang, Michael C., Srinivasan, Karpagam, Friedman, Brad A., Suto, Eric, Modrusan, Zora, Lee, Wyne P., Kaminker, Joshua S., Hansen, David V., Sheng, Morgan
Published in The Journal of experimental medicine (04.09.2017)
Published in The Journal of experimental medicine (04.09.2017)
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Journal Article
A High-Resolution Enhancer Atlas of the Developing Telencephalon
Visel, Axel, Taher, Leila, Girgis, Hani, May, Dalit, Golonzhka, Olga, Hoch, Renee V., McKinsey, Gabriel L., Pattabiraman, Kartik, Silberberg, Shanni N., Blow, Matthew J., Hansen, David V., Nord, Alex S., Akiyama, Jennifer A., Holt, Amy, Hosseini, Roya, Phouanenavong, Sengthavy, Plajzer-Frick, Ingrid, Shoukry, Malak, Afzal, Veena, Kaplan, Tommy, Kriegstein, Arnold R., Rubin, Edward M., Ovcharenko, Ivan, Pennacchio, Len A., Rubenstein, John L.R.
Published in Cell (14.02.2013)
Published in Cell (14.02.2013)
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Journal Article
Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
Rathore, Nisha, Ramani, Sree Ranjani, Pantua, Homer, Payandeh, Jian, Bhangale, Tushar, Wuster, Arthur, Kapoor, Manav, Sun, Yonglian, Kapadia, Sharookh B., Gonzalez, Lino, Zarrin, Ali A., Goate, Alison, Hansen, David V., Behrens, Timothy W., Graham, Robert R.
Published in PLoS genetics (02.11.2018)
Published in PLoS genetics (02.11.2018)
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Journal Article
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Wetzel-Smith, Monica K, Hunkapiller, Julie, Bhangale, Tushar R, Srinivasan, Karpagam, Maloney, Janice A, Atwal, Jasvinder K, Sa, Susan M, B Yaylaoglu, Murat, Foreman, Oded, Ortmann, Ward, Rathore, Nisha, Hansen, David V, Tessier-Lavigne, Marc, Mayeux, Richard, Pericak-Vance, Margaret, Haines, Jonathan, Farrer, Lindsay A, Schellenberg, Gerard D, Goate, Alison, Behrens, Timothy W, Cruchaga, Carlos, Watts, Ryan J, Graham, Robert R
Published in Nature medicine (01.12.2014)
Published in Nature medicine (01.12.2014)
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Journal Article
Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining
Hsiao, Yi-Chun, Wallweber, Heidi Ackerly, Alberstein, Robert G., Lin, Zhonghua, Du, Changchun, Etxeberria, Ainhoa, Aung, Theint, Shang, Yonglei, Seshasayee, Dhaya, Seeger, Franziska, Watkins, Andrew M., Hansen, David V., Bohlen, Christopher J., Hsu, Peter L., Hötzel, Isidro
Published in Nature communications (27.09.2024)
Published in Nature communications (27.09.2024)
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Journal Article
Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells
Hansen, David V., Rubenstein, John L.R., Kriegstein, Arnold R.
Published in Neuron (Cambridge, Mass.) (26.05.2011)
Published in Neuron (Cambridge, Mass.) (26.05.2011)
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Journal Article
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement
Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James A., DiCara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David V., Atwal, Jasvinder, Lu, Yanmei, Bumbaca, Daniela, Pfeifer, Andrea, Watts, Ryan J., Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai
Published in Cell reports (Cambridge) (09.08.2016)
Published in Cell reports (Cambridge) (09.08.2016)
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Journal Article
Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis
Madgwick, Suzanne, Hansen, David V, Levasseur, Mark, Jackson, Peter K, Jones, Keith T
Published in The Journal of cell biology (11.09.2006)
Published in The Journal of cell biology (11.09.2006)
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Journal Article
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
Miller, Julie J., Summers, Matthew K., Hansen, David V., Nachury, Maxence V., Lehman, Norman L., Loktev, Alex, Jackson, Peter K.
Published in Genes & development (01.09.2006)
Published in Genes & development (01.09.2006)
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Journal Article