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A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Kazak, Lawrence, Chouchani, Edward T., Jedrychowski, Mark P., Erickson, Brian K., Shinoda, Kosaku, Cohen, Paul, Vetrivelan, Ramalingam, Lu, Gina Z., Laznik-Bogoslavski, Dina, Hasenfuss, Sebastian C., Kajimura, Shingo, Gygi, Steve P., Spiegelman, Bruce M.
Published in Cell (22.10.2015)
Published in Cell (22.10.2015)
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Journal Article
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.
Published in Nature (London) (07.04.2016)
Published in Nature (London) (07.04.2016)
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Journal Article
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition
Ganji, Rakesh, Paulo, Joao A., Xi, Yuecheng, Kline, Ian, Zhu, Jiang, Clemen, Christoph S., Weihl, Conrad C., Purdy, John G., Gygi, Steve P., Raman, Malavika
Published in Nature communications (06.02.2023)
Published in Nature communications (06.02.2023)
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Journal Article
Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas
Liang, Jiaxin, Yu, Deyang, Luo, Chi, Bennett, Christopher, Jedrychowski, Mark, Gygi, Steve P., Widlund, Hans R., Puigserver, Pere
Published in Nature communications (05.06.2023)
Published in Nature communications (05.06.2023)
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Journal Article
Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation
Zeng, Xing, Jedrychowski, Mark P., Chen, Yi, Serag, Sara, Lavery, Gareth G., Gygi, Steve P., Spiegelman, Bruce M.
Published in Genes & development (15.08.2016)
Published in Genes & development (15.08.2016)
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Journal Article
FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA
Yamazaki, Tomohiro, Chen, Shi, Yu, Yong, Yan, Biao, Haertlein, Tyler C., Carrasco, Monica A., Tapia, Juan C., Zhai, Bo, Das, Rita, Lalancette-Hebert, Melanie, Sharma, Aarti, Chandran, Siddharthan, Sullivan, Gareth, Nishimura, Agnes Lumi, Shaw, Christopher E., Gygi, Steve P., Shneider, Neil A., Maniatis, Tom, Reed, Robin
Published in Cell reports (Cambridge) (25.10.2012)
Published in Cell reports (Cambridge) (25.10.2012)
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Journal Article
Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity
Gyuris, Aron, Navarrete-Perea, Jose, Jo, Ala, Cristea, Simona, Zhou, Shuang, Fraser, Kyle, Wei, Zhiyun, Krichevsky, Anna M., Weissleder, Ralph, Lee, Hakho, Gygi, Steve P., Charest, Al
Published in Cell reports (Cambridge) (25.06.2019)
Published in Cell reports (Cambridge) (25.06.2019)
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Journal Article
USP14 inhibition enhances Parkin-independent mitophagy in iNeurons
Bernardo, Greta, Prado, Miguel A., Dashtmian, Anna Roshani, Favaro, Mariavittoria, Mauri, Sofia, Borsetto, Alice, Marchesan, Elena, Paulo, Joao A., Gygi, Steve P., Finley, Daniel J., Ziviani, Elena
Published in Pharmacological research (01.12.2024)
Published in Pharmacological research (01.12.2024)
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Journal Article
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations
Barrow, Joeva J., Balsa, Eduardo, Verdeguer, Francisco, Tavares, Clint D.J., Soustek, Meghan S., Hollingsworth, Louis R., Jedrychowski, Mark, Vogel, Rutger, Paulo, Joao A., Smeitink, Jan, Gygi, Steve P., Doench, John, Root, David E., Puigserver, Pere
Published in Molecular cell (06.10.2016)
Published in Molecular cell (06.10.2016)
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Journal Article
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
Jun, Hyun Jung, Appleman, Vicky A., Wu, Hua-Jun, Rose, Christopher M., Pineda, Javier J., Yeo, Alan T., Delcuze, Bethany, Lee, Charlotte, Gyuris, Aron, Zhu, Haihao, Woolfenden, Steve, Bronisz, Agnieszka, Nakano, Ichiro, Chiocca, Ennio A., Bronson, Roderick T., Ligon, Keith L., Sarkaria, Jann N., Gygi, Steve P., Michor, Franziska, Mitchison, Timothy J., Charest, Al
Published in Nature communications (06.08.2018)
Published in Nature communications (06.08.2018)
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Journal Article
Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly
Lucena, Rafael, Dephoure, Noah, Gygi, Steve P., Kellogg, Douglas R., Tallada, Victor A., Daga, Rafael R., Jimenez, Juan
Published in The Journal of cell biology (11.05.2015)
Published in The Journal of cell biology (11.05.2015)
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Journal Article
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis
Balsa, Eduardo, Soustek, Meghan S., Thomas, Ajith, Cogliati, Sara, García-Poyatos, Carolina, Martín-García, Elena, Jedrychowski, Mark, Gygi, Steve P., Enriquez, José Antonio, Puigserver, Pere
Published in Molecular cell (06.06.2019)
Published in Molecular cell (06.06.2019)
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Journal Article
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation
Ahlstedt, Brittany A, Ganji, Rakesh, Mukkavalli, Sirisha, Paulo, Joao A, Gygi, Steve P, Raman, Malavika
Published in EMBO reports (13.02.2024)
Published in EMBO reports (13.02.2024)
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Journal Article
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
Sharabi, Kfir, Lin, Hua, Tavares, Clint D.J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere
Published in Cell (23.03.2017)
Published in Cell (23.03.2017)
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Journal Article
Large-Scale Phosphorylation Analysis of α-Factor-Arrested Saccharomyces cerevisiae
Li, Xue, Gerber, Scott A, Rudner, Adam D, Beausoleil, Sean A, Haas, Wilhelm, Villén, Judit, Elias, Joshua E, Gygi, Steve P
Published in Journal of proteome research (01.03.2007)
Published in Journal of proteome research (01.03.2007)
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Journal Article
Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death
Mohideen, Firaz, Paulo, Joao A., Ordureau, Alban, Gygi, Steve P., Harper, J. Wade
Published in Molecular & cellular proteomics (01.07.2017)
Published in Molecular & cellular proteomics (01.07.2017)
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Journal Article
Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
Soustek, Meghan S., Balsa, Eduardo, Barrow, Joeva J., Jedrychowski, Mark, Vogel, Rutger, Jan Smeitink, Gygi, Steve P., Puigserver, Pere
Published in Cell death & disease (31.05.2018)
Published in Cell death & disease (31.05.2018)
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Journal Article
Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products
Nash, Bradley, Gregory, William F., White, Rhiannon R., Protasio, Anna V., Gygi, Steve P., Selkirk, Murray E., Weekes, Michael P., Artavanis-Tsakonas, Katerina
Published in Frontiers in parasitology (25.01.2023)
Published in Frontiers in parasitology (25.01.2023)
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Journal Article