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A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry
Graham, Richard A., Lum, Bert L., Morrison, Glenn, Chang, Ilsung, Jorga, Karin, Dean, Brian, Shin, Young G., Yue, Qin, Mulder, Teresa, Malhi, Vikram, Xie, Minli, Low, Jennifer A., Hop, Cornelis ECA
Published in Drug metabolism and disposition (01.08.2011)
Published in Drug metabolism and disposition (01.08.2011)
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Journal Article
Bioavailability of the hedgehog pathway inhibitor GDC-0449 in a phase I pharmacokinetic (PK) study in healthy female subjects
Graham, R. A., Morrison, G. E., Chang, I., Jorga, K., Hop, C., Shin, Y., Malhi, V., Xie, M., Low, J. A., Lum, B. L.
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
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Journal Article
A phase I, open-label mass balance study of the hedgehog pathway inhibitor (HPI) GDC-0449 in healthy female subjects of non-childbearing potential
Lum, B. L., Morrison, G. E., Chang, I., Jorga, K., Hop, C., Shin, Y., Malhi, V., Xie, M., Low, J. A., Graham, R. A.
Published in Journal of clinical oncology (20.05.2010)
Published in Journal of clinical oncology (20.05.2010)
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Journal Article
Abstract LB-1: An investigator-initiated, phase II randomized, double-blind, placebo-controlled trial of GDC-0449 for prevention of BCCs in basal cell nevus syndrome (BCNS) patients.gg
Tang, Jean Y., Mackay-Wiggan, Julian M., Aszterbaum, Michelle, Lindgren, Joselyn, Chang, Kris, Coppola, Carol, Campbell, Angela, Chanana, Anita, Marji, Jackleen, Callahan, Chris, Yauch, Robert, Bickers, David R., Epstein, Ervin H.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects
Graham, Richard A., Hop, Cornelis E. C. A., Borin, Marie T., Lum, Bert L., Colburn, Dawn, Chang, Ilsung, Shin, Young G., Malhi, Vikram, Low, Jennifer A., Dresser, Mark J.
Published in British journal of clinical pharmacology (01.11.2012)
Published in British journal of clinical pharmacology (01.11.2012)
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Journal Article
A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation
Dolton, Michael J., Chiang, Po-Chang, Ma, Fang, Jin, Jin Y., Chen, Yuan
Published in The AAPS journal (01.09.2020)
Published in The AAPS journal (01.09.2020)
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Journal Article
A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib
Malhi, Vikram, Colburn, Dawn, Williams, Sarah J., Hop, Cornelis E. C. A., Dresser, Mark J., Chandra, Priya, Graham, Richard A.
Published in Cancer chemotherapy and pharmacology (01.07.2016)
Published in Cancer chemotherapy and pharmacology (01.07.2016)
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