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EXTH-47. TUMOUR-TARGETED PAN-RAS INHIBITION AS A NOVEL THERAPY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
Sbergio, Stefanie-Grace, Liang, Peter, Beilhartz, Greg, Patel, Palak, Vadivel, Arun Anguraj, Melnyk, Roman, Hawkins, Cynthia
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
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Journal Article
EXTH-65. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS COMPARISON OF BRAF AND MEK INHIBITORS FOLLOWING SINGLE AND EXTENDED ADMINISTRATION IN A PRE-CLINICAL NON-HUMAN PRIMATE MODEL
Lester McCully, Cynthia, Gross, Andrea, Cruz Garcia, Rafael, Shankarappa, Priya, Odabas, Arman, Rodgers, Louis, Peer, Cody, Figg, William, Widemann, Brigitte, Warren, Katherine
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
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Journal Article
Pharmacokinetics, Tolerability, and Safety of Murepavadin, a Novel Antipseudomonal Antibiotic, in Subjects with Mild, Moderate, or Severe Renal Function Impairment
Dale, Glenn E., Halabi, Atef, Petersen-Sylla, Marc, Wach, Achim, Zwingelstein, Christian
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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Journal Article
Phase 1 Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Oral Doses of DS-2969b, a Novel GyrB Inhibitor, in Healthy Subjects
Vandell, Alexander G., Inoue, Satoshi, Dennie, Justin, Nagasawa, Yasuo, Gajee, Roohi, Pav, Joe, Zhang, George, Zamora, Cynthia, Masuda, Nobuhisa, Senaldi, Giorgio
Published in Antimicrobial Agents and Chemotherapy (01.05.2018)
Published in Antimicrobial Agents and Chemotherapy (01.05.2018)
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Journal Article
Single- and Multiple-Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative SPR206
Bruss, Jon, Lister, Troy, Gupta, Vipul K., Stone, Emily, Morelli, Lisa, Lei, Yang, Melnick, David
Published in Antimicrobial agents and chemotherapy (17.09.2021)
Published in Antimicrobial agents and chemotherapy (17.09.2021)
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Journal Article
Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study of the Penetration of a Monoclonal Antibody Combination (ASN100) Targeting Staphylococcus aureus Cytotoxins in the Lung Epithelial Lining Fluid of Healthy Volunteers
Magyarics, Zoltan, Leslie, Fraser, Bartko, Johann, Rouha, Harald, Luperchio, Steven, Schörgenhofer, Christian, Schwameis, Michael, Derhaschnig, Ulla, Lagler, Heimo, Stiebellehner, Leopold, Firbas, Christa, Weber, Susanne, Campanaro, Ed, Jilma, Bernd, Nagy, Eszter, Stevens, Chris
Published in Antimicrobial agents and chemotherapy (01.08.2019)
Published in Antimicrobial agents and chemotherapy (01.08.2019)
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Journal Article
Population Pharmacokinetics of Tafenoquine, a Novel Antimalarial
Thakkar, Nilay, Green, Justin A., Koh, Gavin C. K. W., Duparc, Stephan, Tenero, David, Goyal, Navin
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Published in Antimicrobial agents and chemotherapy (01.11.2018)
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Journal Article
First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Single Doses of NTM-1633, a Novel Mixture of Monoclonal Antibodies against Botulinum Toxin E
Raja, S. M., Guptill, J. T., Juel, V. C., Walter, E. B., Cohen-Wolkowiez, M., Hill, H., Sendra, E., Hauser, B., Jackson, P., Tomic, M., Espinoza, Y., Swamy, G. K.
Published in Antimicrobial agents and chemotherapy (19.04.2022)
Published in Antimicrobial agents and chemotherapy (19.04.2022)
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Journal Article
I19 The defective metabolism of polysialic acid (polysia) may represent an effective therapeutic target in hd pre-clinical models
Pepe, Giuseppe, Capocci, Luca, Marracino, Federico, Moons, Sam J, Sönmez, Aynur, Świtońska-Kurkowska, Karolina, Scarselli, Pamela, Cicco, Clotilde Di, Figiel, Maciej, Boltje, Thomas J, Parlato, Rosanna, Pardo, Alba Di, Maglione, Vittorio
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2022)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2022)
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Journal Article
Early Bactericidal Activity of Delpazolid (LCB01-0371) in Patients with Pulmonary Tuberculosis
Kim, Ju Sang, Kim, Yong-hyun, Lee, Sang Haak, Kim, Yee Hyung, Kim, Jin-woo, Kang, Ji Young, Kim, Sung Kyoung, Kim, Seung Joon, Kang, Yun-Seong, Kim, Tae-hyung, Mok, Jeongha, Byun, Min Kwang, Park, Hye Jung, Joh, Joon-sung, Park, Yong Bum, Lim, Hyeong-Seok, Choi, Hongjo, Lee, Seung Heon, Kim, Hyejin, Yang, Jeongseong, Kim, Hyunji, Shen, Xianlin, Alsultan, Abdullah, Cho, InSook, Geiter, Lawrence, Shim, Tae Sun
Published in Antimicrobial agents and chemotherapy (15.02.2022)
Published in Antimicrobial agents and chemotherapy (15.02.2022)
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Journal Article
A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome
Yao, Jiangwei, Carter, Robert A., Vuagniaux, Grégoire, Barbier, Maryse, Rosch, Jason W., Rock, Charles O.
Published in Antimicrobial agents and chemotherapy (01.07.2016)
Published in Antimicrobial agents and chemotherapy (01.07.2016)
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Journal Article
Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an In Vitro Wound Model
Crowther, G. S., Callaghan, N., Bayliss, M., Noel, A., Morley, R., Price, B.
Published in Antimicrobial agents and chemotherapy (18.05.2021)
Published in Antimicrobial agents and chemotherapy (18.05.2021)
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Journal Article
Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus
Waterer, Grant, Lord, John, Hofmann, Thomas, Jouhikainen, Taneli
Published in Antimicrobial agents and chemotherapy (21.02.2020)
Published in Antimicrobial agents and chemotherapy (21.02.2020)
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Journal Article
Safety, Tolerability, and Pharmacokinetics of NTM-1632, a Novel Mixture of Three Monoclonal Antibodies against Botulinum Toxin B
Guptill, J. T., Raja, S. M., Juel, V. C., Walter, E. B., Cohen-Wolkowiez, M., Hill, H., Sendra, E., Hauser, B., Jackson, P., Swamy, G. K.
Published in Antimicrobial agents and chemotherapy (17.06.2021)
Published in Antimicrobial agents and chemotherapy (17.06.2021)
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Journal Article