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Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial
Yazici, Yusuf, McAlindon, Timothy E., Gibofsky, Allan, Lane, Nancy E., Clauw, Daniel, Jones, Morgan, Bergfeld, John, Swearingen, Christopher J., DiFrancesco, Anita, Simsek, Ismail, Tambiah, Jeyanesh, Hochberg, Marc C.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
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Journal Article
DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies
Ji, Jianling, Lee, Hane, Argiropoulos, Bob, Dorrani, Naghmeh, Mann, John, Martinez-Agosto, Julian A, Gomez-Ospina, Natalia, Gallant, Natalie, Bernstein, Jonathan A, Hudgins, Louanne, Slattery, Leah, Isidor, Bertrand, Le Caignec, Cédric, David, Albert, Obersztyn, Ewa, Wiśniowiecka-Kowalnik, Barbara, Fox, Michelle, Deignan, Joshua L, Vilain, Eric, Hendricks, Emily, Horton Harr, Margaret, Noon, Sarah E, Jackson, Jessi R, Wilkens, Alisha, Mirzaa, Ghayda, Salamon, Noriko, Abramson, Jeff, Zackai, Elaine H, Krantz, Ian, Innes, A Micheil, Nelson, Stanley F, Grody, Wayne W, Quintero-Rivera, Fabiola
Published in European journal of human genetics : EJHG (01.11.2015)
Published in European journal of human genetics : EJHG (01.11.2015)
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Journal Article
Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
Harada, Eriko, Yoshida, Saishu, Imaizumi, Yuta, Kawamura, Akira, Ohtsuka, Takashi, Yoshida, Kiyotsugu
Published in Biochimica et biophysica acta. General subjects (01.06.2024)
Published in Biochimica et biophysica acta. General subjects (01.06.2024)
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Journal Article
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
Evangelou, Evangelos, Kerkhof, Hanneke J, Styrkarsdottir, Unnur, Ntzani, Evangelia E, Bos, Steffan D, Esko, Tonu, Evans, Daniel S, Metrustry, Sarah, Panoutsopoulou, Kalliope, Ramos, Yolande F M, Thorleifsson, Gudmar, Tsilidis, Konstantinos K, Arden, Nigel, Aslam, Nadim, Bellamy, Nicholas, Birrell, Fraser, Blanco, Francisco J, Carr, Andrew, Chapman, Kay, Day-Williams, Aaron G, Deloukas, Panos, Doherty, Michael, Engström, Gunnar, Helgadottir, Hafdis T, Hofman, Albert, Ingvarsson, Thorvaldur, Jonsson, Helgi, Keis, Aime, Keurentjes, J Christiaan, Kloppenburg, Margreet, Lind, Penelope A, McCaskie, Andrew, Martin, Nicholas G, Milani, Lili, Montgomery, Grant W, Nelissen, Rob G H H, Nevitt, Michael C, Nilsson, Peter M, Ollier, William ER, Parimi, Neeta, Rai, Ashok, Ralston, Stuart H, Reed, Mike R, Riancho, Jose A, Rivadeneira, Fernando, Rodriguez-Fontenla, Cristina, Southam, Lorraine, Thorsteinsdottir, Unnur, Tsezou, Aspasia, Wallis, Gillian A, Wilkinson, J Mark, Gonzalez, Antonio, Lane, Nancy E, Lohmander, L Stefan, Loughlin, John, Metspalu, Andres, Uitterlinden, Andre G, Jonsdottir, Ingileif, Stefansson, Kari, Slagboom, P Eline, Zeggini, Eleftheria, Meulenbelt, Ingrid, Ioannidis, John PA, Spector, Tim D, van Meurs, Joyce B J, Valdes, Ana M
Published in Annals of the rheumatic diseases (01.12.2014)
Published in Annals of the rheumatic diseases (01.12.2014)
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Journal Article
Inhibition of DYRK1A can alleviate MPTP/MPP+-induced neuronal apoptosis and mitochondrial damage
Cai, Qian, Xia, Huan, Li, Peishan, Yao, Yani, Luo, Qin, Yang, Xinling
Published in Brain research bulletin (01.10.2025)
Published in Brain research bulletin (01.10.2025)
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Journal Article
[125I]IPPI for Tau Imaging: Binding Studies in Postmortem Human Alzheimer's Disease Hippocampus‐Subiculum and Evaluation of Drug Effects
Karim, Fariha, Delaney, Brooke A., Mondal, Rommani, Liang, Christopher, Serrano, Geidy E., Beach, Thomas G., Mukherjee, Jogeshwar
Published in Synapse (New York, N.Y.) (01.07.2025)
Published in Synapse (New York, N.Y.) (01.07.2025)
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Journal Article
Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability
Utani, Koichi, Fu, Haiqing, Jang, Sang-Min, Marks, Anna B., Smith, Owen K., Zhang, Ya, Redon, Christophe E., Shimizu, Noriaki, Aladjem, Mirit I.
Published in Nucleic acids research (27.07.2017)
Published in Nucleic acids research (27.07.2017)
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Journal Article
Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [125I]Radioiodinated DYRK1A Inhibitor
Paclibar, Cayz G., Schafer, Deanna M., Biju, Agnes P., Karim, Fariha, Sison, Stephanie A., Liang, Christopher, Ahmed, Shamiha T., Mukherjee, Jogeshwar
Published in Molecules (Basel, Switzerland) (21.02.2025)
Published in Molecules (Basel, Switzerland) (21.02.2025)
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Journal Article
DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives
Neumann, Fernanda, Gourdain, Stéphanie, Albac, Christelle, Dekker, Alain D., Bui, Linh Chi, Dairou, Julien, Schmitz-Afonso, Isabelle, Hue, Nathalie, Rodrigues-Lima, Fernando, Delabar, Jean M., Potier, Marie-Claude, Le Caër, Jean-Pierre, Touboul, David, Delatour, Benoît, Cariou, Kevin, Dodd, Robert H.
Published in Scientific reports (12.02.2018)
Published in Scientific reports (12.02.2018)
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Journal Article
Diabetic Kinome Inhibitors—A New Opportunity for β-Cells Restoration
Pucelik, Barbara, Barzowska, Agata, Dąbrowski, Janusz M., Czarna, Anna
Published in International journal of molecular sciences (23.08.2021)
Published in International journal of molecular sciences (23.08.2021)
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Journal Article
Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1‐induced cell cycle arrest
Pérez‐Sánchez, Gilberto, Jiménez, Adriana, Quezada‐Ramírez, Marco A., Estudillo, Enrique, Ayala‐Sarmiento, Alberto E., Mendoza‐Hernández, Guillermo, Hernández‐Soto, Justino, Hernández‐Hernández, Fidel C., Cázares‐Raga, Febe E., Segovia, Jose
Published in Journal of cellular physiology (01.05.2018)
Published in Journal of cellular physiology (01.05.2018)
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Journal Article
Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians
Mohamed, Yara Ahmed, Hassaneen, H. M., El-Dessouky, Mohamed A., Safwat, Gehan, Hassan, Naglaa Abu-Mandil, Amr, Khalda
Published in Molecular biology reports (01.07.2021)
Published in Molecular biology reports (01.07.2021)
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Journal Article
Link Between DYRK1A Overexpression and Several-Fold Enhancement of Neurofibrillary Degeneration With 3-Repeat Tau Protein in Down Syndrome
Wegiel, Jerzy, Kaczmarski, Wojciech, Barua, Madhabi, Kuchna, Izabela, Nowicki, Krzysztof, Wang, Kuo-Chiang, Wegiel, Jarek, Yang, Shuang, Frackowiak, Janusz, Mazur-Kolecka, Bozena, Silverman, Wayne P., Reisberg, Barry, Monteiro, Isabel, de Leon, Mony, Wisniewski, Thomas, Dalton, Arthur, Lai, Florence, Hwang, Yu-Wen, Adayev, Tatyana, Liu, Fei, Iqbal, Khalid, Iqbal, Inge-Grundke, Gong, Cheng-Xin
Published in Journal of neuropathology and experimental neurology (01.01.2011)
Published in Journal of neuropathology and experimental neurology (01.01.2011)
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Journal Article
The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase
Song, Liang-Nian, Silva, Jose, Koller, Antonius, Rosenthal, Andrew, Chen, Emily I., Gelmann, Edward P.
Published in Molecular cancer research (01.05.2015)
Published in Molecular cancer research (01.05.2015)
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Journal Article
The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
Wegiel, Jerzy, Dowjat, Karol, Kaczmarski, Wojciech, Kuchna, Izabela, Nowicki, Krzysztof, Frackowiak, Janusz, Mazur Kolecka, Bozena, Wegiel, Jarek, Silverman, Wayne P., Reisberg, Barry, deLeon, Mony, Wisniewski, Thomas, Gong, Cheng-Xin, Liu, Fei, Adayev, Tatyana, Chen-Hwang, Mo-Chou, Hwang, Yu-Wen
Published in Acta neuropathologica (01.10.2008)
Published in Acta neuropathologica (01.10.2008)
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Journal Article
Gene Dosage–Dependent Association of DYRK1A With the Cytoskeleton in the Brain and Lymphocytes of Down Syndrome Patients
Dowjat, Karol, Adayev, Tatyana, Kaczmarski, Wojciech, Wegiel, Jerzy, Hwang, Yu-Wen
Published in Journal of neuropathology and experimental neurology (01.12.2012)
Published in Journal of neuropathology and experimental neurology (01.12.2012)
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Journal Article