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An Open‐Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM‐080301 in Subjects with Advanced Hepatocellular Carcinoma
El Dika, Imane, Lim, Ho Yeong, Yong, Wei Peng, Lin, Chia‐Chi, Yoon, Jung‐Hwan, Modiano, Manuel, Freilich, Bradley, Choi, Hye Jin, Chao, Tsu‐Yi, Kelley, Robin K., Brown, Joanne, Knox, Jennifer, Ryoo, Baek‐Yeol, Yau, Thomas, Abou‐Alfa, Ghassan K.
Published in The oncologist (Dayton, Ohio) (01.06.2019)
Published in The oncologist (Dayton, Ohio) (01.06.2019)
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Journal Article
A comparative study of the effects of imeglimin add‐on or metformin dose escalation on glycaemic variability in subjects with type 2 diabetes treated with low‐dose metformin (MEGMI‐CGM study)
Takahashi, Akihiro, Nomoto, Hiroshi, Onishi, Kinnosuke, Manda, Satoru, Miya, Aika, Kameda, Hiraku, Nakamura, Akinobu, Atsumi, Tatsuya
Published in Diabetes, obesity & metabolism (01.08.2024)
Published in Diabetes, obesity & metabolism (01.08.2024)
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Journal Article
Donanemab (LY3002813) dose‐escalation study in Alzheimer's disease
Lowe, Stephen Loucian, Willis, Brian A., Hawdon, Anne, Natanegara, Fanni, Chua, Laiyi, Foster, Joanne, Shcherbinin, Sergey, Ardayfio, Paul, Sims, John R.
Published in Alzheimer's & dementia : translational research & clinical interventions (2021)
Published in Alzheimer's & dementia : translational research & clinical interventions (2021)
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Journal Article
A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors
Ferrarotto, R., Eckhardt, G., Patnaik, A., LoRusso, P., Faoro, L., Heymach, J.V., Kapoun, A.M., Xu, L., Munster, P.
Published in Annals of oncology (01.07.2018)
Published in Annals of oncology (01.07.2018)
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Journal Article
Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity
Winstedt, Lena, Järnum, Sofia, Nordahl, Emma Andersson, Olsson, Andreas, Runström, Anna, Bockermann, Robert, Karlsson, Christofer, Malmström, Johan, Palmgren, Gabriella Samuelsson, Malmqvist, Ulf, Björck, Lars, Kjellman, Christian
Published in PloS one (15.07.2015)
Published in PloS one (15.07.2015)
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Journal Article
Effectiveness of Reinduction and/or Dose Escalation of Ustekinumab in Crohn’s Disease: A Systematic Review and Meta-analysis
Meserve, Joseph, Ma, Christopher, Dulai, Parambir S., Jairath, Vipul, Singh, Siddharth
Published in Clinical gastroenterology and hepatology (01.12.2022)
Published in Clinical gastroenterology and hepatology (01.12.2022)
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Journal Article
Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects
Kato, Manabu, Furuie, Hidetoshi, Shimizu, Takako, Miyazaki, Atsuhiro, Kobayashi, Fumiaki, Ishizuka, Hitoshi
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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Journal Article
Evaluation of a Janus kinase 1 inhibitor, PF‐04965842, in healthy subjects: A phase 1, randomized, placebo‐controlled, dose‐escalation study
Peeva, Elena, Hodge, Martin R., Kieras, Elizabeth, Vazquez, Michael L., Goteti, Kosalaram, Tarabar, Sanela G., Alvey, Christine W., Banfield, Christopher
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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Journal Article
First‐in‐human, randomized dose‐escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF‐06480605 in healthy subjects
Banfield, Christopher, Rudin, Dan, Bhattacharya, Indranil, Goteti, Kosalaram, Li, Gang, Hassan‐Zahraee, Mina, Brown, Lisa S., Hung, Kenneth E., Pawlak, Sylvester, Lepsy, Christopher
Published in British journal of clinical pharmacology (01.04.2020)
Published in British journal of clinical pharmacology (01.04.2020)
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Journal Article
Efficacy of imeglimin treatment versus metformin dose escalation on glycemic control in subjects with type 2 diabetes treated with a dipeptidyl peptidase‐4 inhibitor plus low‐dose metformin: A multicenter, prospective, randomized, open‐label, parallel‐group comparison study (MEGMI study)
Takahashi, Akihiro, Nomoto, Hiroshi, Yokoyama, Hiroki, Yokozeki, Kei, Furusawa, Sho, Oe, Yuki, Kameda, Reina, Kawata, Shinichiro, Miyoshi, Arina, Nagai, So, Miya, Aika, Kameda, Hiraku, Nakamura, Akinobu, Atsumi, Tatsuya
Published in Diabetes, obesity & metabolism (01.03.2025)
Published in Diabetes, obesity & metabolism (01.03.2025)
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Journal Article
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study
Bloor, Adrian J. C., Patel, Amit, Griffin, James E., Gilleece, Maria H., Radia, Rohini, Yeung, David T., Drier, Diana, Larson, Laurie S., Uenishi, Gene I., Hei, Derek, Kelly, Kilian, Slukvin, Igor, Rasko, John E. J.
Published in Nature medicine (01.11.2020)
Published in Nature medicine (01.11.2020)
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Journal Article
Phase 1b, multicenter, single blinded, placebo‐controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy
Limaye, Sewanti Atul, Haddad, Robert I., Cilli, Fiona, Sonis, Stephen T., Colevas, A. Dimitrios, Brennan, Michael T., Hu, Kenneth S., Murphy, Barbara A.
Published in Cancer (15.12.2013)
Published in Cancer (15.12.2013)
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Journal Article
Dose intra‐subject escalation to an event (DIETE): A new method for phase 1 dose‐finding utilizing systematic intra‐subject dose escalation with application to T‐cell engagers
Xu, Chenjia, Zhuo, Bin, Rasmussen, Hans Erik
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.11.2021)
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.11.2021)
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Journal Article
Human dose-escalation study of PET imaging CD8+ T-cell infiltration in solid malignancies with [68Ga]Ga -NODAGA-SNA006
Wang, Yan, Zheng, Meng, Zhao, Jun, Wang, Chao, Zhao, Shandong, Bian, Yicong, Dai, Na, Zheng, Yushuang, Sang, Shibiao, Guo, Linchuan, Huang, Chenrong, Zhang, Hua, Jiang, Jiwei, Xu, Chun, Zhao, Qi, Han, Jiajun, Xu, Tao, Qin, Songbing, Miao, Liyan
Published in European journal of nuclear medicine and molecular imaging (01.03.2025)
Published in European journal of nuclear medicine and molecular imaging (01.03.2025)
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Journal Article
Completed phase 1a dose escalation study of the first oral ENPP1 inhibitor RBS2418 immunotherapy in subjects with metastatic solid tumors
Wainberg, Zev A., Spira, Alexander I., Gordon, Michael S., Chen, Christopher T., Segar, Jennifer Margaret, Scott, Aaron J., Boccia, Ralph V., Johnson, Daniel H., Berlin, Jordan, Ho, Won Jin, Schanzer, Juergen, Sengupta, Deepanwita, Huang, Ningwu, Glenn, Jeffrey S., Csiki, Ildiko, Klumpp, Klaus, Misleh, Jamal Ghazi
Published in Journal of clinical oncology (01.06.2025)
Published in Journal of clinical oncology (01.06.2025)
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Journal Article
Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial
Georgoff, Patrick E., Nikolian, Vahagn C., Bonham, Tess, Pai, Manjunath P., Tafatia, Celia, Halaweish, Ihab, To, Kathleen, Watcharotone, Kuanwong, Parameswaran, Aishwarya, Luo, Ruijuan, Sun, Duxin, Alam, Hasan B.
Published in Clinical pharmacokinetics (01.02.2018)
Published in Clinical pharmacokinetics (01.02.2018)
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Journal Article
Safety, tolerability, pharmacokinetic, pharmacodynamic and immunogenicity profiles of Exendin‐4‐IgG4‐Fc in healthy subjects: A phase 1, single‐centre, randomized, double‐blind, dose escalation study
Chen, Gui‐Ling, Liu, Yang, Gao, Xue‐Feng, Wu, Kai‐Qi, Yang, Yun‐Kai, Chen, Yong, Peng, Cong‐Gao, Jin, Ting‐Han, Huang, Yu‐Bao, Zhang, Yao‐Wen, Su, Jing, Jiang, Qi, Guo, Tong, Zhao, Jie, Peng, Xiang‐Nan, Peng, Jing‐Yu, Li, Si‐Xiu, Sun, Yong‐Li, Zhang, Hong‐Mei, Fu, Yan‐Li, Luo, Dan, Ma, Yaru, Shen, Zhen‐Wei, Zhang, Yun‐Tao, Shou, Zhang‐Fei
Published in Diabetes, obesity & metabolism (01.04.2024)
Published in Diabetes, obesity & metabolism (01.04.2024)
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Journal Article
A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease
Xu, Julia Z., Conrey, Anna, Frey, Ingrid, Gwaabe, Eveline, Menapace, Laurel A., Tumburu, Laxminath, Lundt, Maureen, Lequang, Timothy, Li, Quan, Glass, Kristen, Dunkelberger, Emily B., Iyer, Varsha, Mangus, Heidi, Kung, Charles, Dang, Lenny, Kosinski, Penelope A., Hawkins, Peter, Jeffries, Neal, Eaton, William A., Lay Thein, Swee
Published in Blood (10.11.2022)
Published in Blood (10.11.2022)
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Journal Article
Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study
Goldberg, Avram, Geppert, Thomas, Schiopu, Elena, Frech, Tracy, Hsu, Vivien, Simms, Robert W, Peng, Stanford L, Yao, Yihong, Elgeioushi, Nairouz, Chang, Linda, Wang, Bing, Yoo, Stephen
Published in Arthritis research & therapy (24.02.2014)
Published in Arthritis research & therapy (24.02.2014)
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Journal Article
Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial
Constable, Ian J., Lai, Chooi-May, Magno, Aaron L., French, Martyn A., Barone, Samuel B., Schwartz, Steven D., Blumenkranz, Mark S., Degli-Esposti, Mariapia A., Rakoczy, Elizabeth P.
Published in American journal of ophthalmology (01.05.2017)
Published in American journal of ophthalmology (01.05.2017)
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Journal Article