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Could AlphaFold revolutionize chemical therapeutics?
Tong, Alexander B., Burch, Jason D., McKay, Daniel, Bustamante, Carlos, Crackower, Michael A., Wu, Hao
Published in Nature structural & molecular biology (01.10.2021)
Published in Nature structural & molecular biology (01.10.2021)
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Journal Article
Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells
Burton, Oliver T., Noval Rivas, Magali, Zhou, Joseph S., Logsdon, Stephanie L., Darling, Alanna R., Koleoglou, Kyle J., Roers, Axel, Houshyar, Hani, Crackower, Michael A., Chatila, Talal A., Oettgen, Hans C.
Published in Immunity (Cambridge, Mass.) (17.07.2014)
Published in Immunity (Cambridge, Mass.) (17.07.2014)
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Journal Article
Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen
Dorich, Stéphane, Auger, Anick, Wang, Li, Burch, Jason, Pellerin, Charles, Chan, Silas, Raymond, Marianne, Zhang, Lingling, Chefson, Amandine, Germain, Marie-Anne, Jananji, Silvana, Dumais, Valérie, Gaudreault, Samuel, Caron, Alexandre, Dumas-Bérubé, Émilie, A. Crackower, Michael
Published in Bioorganic & medicinal chemistry letters (01.07.2025)
Published in Bioorganic & medicinal chemistry letters (01.07.2025)
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Journal Article
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Yumiko, Kuba, Keiji, Rao, Shuan, Huan, Yi, Guo, Feng, Guan, Bin, Yang, Peng, Sarao, Renu, Wada, Teiji, Leong-Poi, Howard, Crackower, Michael A., Fukamizu, Akiyoshi, Hui, Chi-Chung, Hein, Lutz, Uhlig, Stefan, Slutsky, Arthur S., Jiang, Chengyu, Penninger, Josef M.
Published in Nature (London) (07.07.2005)
Published in Nature (London) (07.07.2005)
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Journal Article
Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus
Bai, Jianwu, Smock, Steven L., Jackson, George R., MacIsaac, Kenzie D., Huang, Yongsheng, Mankus, Courtney, Oldach, Jonathan, Roberts, Brian, Ma, Yu-Lu, Klappenbach, Joel A., Crackower, Michael A., Alves, Stephen E., Hayden, Patrick J.
Published in PloS one (23.02.2015)
Published in PloS one (23.02.2015)
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Journal Article
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
Wang, I‐Ming, Zhang, Bin, Yang, Xia, Zhu, Jun, Stepaniants, Serguei, Zhang, Chunsheng, Meng, Qingying, Peters, Mette, He, Yudong, Ni, Chester, Slipetz, Deborah, Crackower, Michael A, Houshyar, Hani, Tan, Christopher M, Asante‐Appiah, Ernest, O'Neill, Gary, Jane Luo, Mingjuan, Thieringer, Rolf, Yuan, Jeffrey, Chiu, Chi‐Sung, Yee Lum, Pek, Lamb, John, Boie, Yves, Wilkinson, Hilary A, Schadt, Eric E, Dai, Hongyue, Roberts, Christopher
Published in Molecular systems biology (17.07.2012)
Published in Molecular systems biology (17.07.2012)
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Journal Article
Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein
Sohal, Dawinder S., Nghiem, Mai, Crackower, Michael A., Witt, Sandra A., Kimball, Thomas R., Tymitz, Kevin M., Penninger, Josef M., Molkentin, Jeffery D.
Published in Circulation research (06.07.2001)
Published in Circulation research (06.07.2001)
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Journal Article
Structural insight into the cGAS active site explains differences between therapeutically relevant species
Skeldon, Alexander M., Wang, Li, Sgarioto, Nicolas, Beveridge, Ramsay E., Chan, Silas, Dorich, Stephane, Dumais, Valerie, Fradet, Nadine, Gaudreault, Samuel, LeGros, Philippe, McKay, Daniel, Seliniotakis, Ria, Sietsema, Daniel V., Zhang, Lingling, Boily, Marc-Olivier, Burch, Jason D., Caron, Alex, Fader, Lee D., Lama, Lodoe, Xie, Wei, Patel, Dinshaw J., Tuschl, Thomas, Crackower, Michael A., Pike, Kelly A.
Published in Communications chemistry (22.03.2025)
Published in Communications chemistry (22.03.2025)
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Journal Article
Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways
Crackower, Michael A., Oudit, Gavin Y., Kozieradzki, Ivona, Sarao, Renu, Sun, Hui, Sasaki, Takehiko, Hirsch, Emilio, Suzuki, Akira, Shioi, Tetsuo, Irie-Sasaki, Junko, Sah, Rajan, Cheng, Hai-Ying M., Rybin, Vitalyi O., Lembo, Giuseppe, Fratta, Luigi, Oliveira-dos-Santos, Antonio J., Benovic, Jeffery L., Kahn, C.Ronald, Izumo, Seigo, Steinberg, Susan F., Wymann, Matthias P., Backx, Peter H., Penninger, Josef M.
Published in Cell (20.09.2002)
Published in Cell (20.09.2002)
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Journal Article
Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist
Gervais, Francois G., Sawyer, Nicole, Stocco, Rino, Hamel, Martine, Krawczyk, Connie, Sillaots, Susan, Denis, Danielle, Wong, Elizabeth, Wang, Zhaoyin, Gallant, Michel, Abraham, William M., Slipetz, Deborah, Crackower, Michael A., O’Neill, Gary P.
Published in Molecular pharmacology (01.01.2011)
Published in Molecular pharmacology (01.01.2011)
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Journal Article
Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene
Fourtounis, Jimmy, Wang, I-Ming, Mathieu, Marie-Claude, Claveau, David, Loo, Tenneille, Jackson, Aimee L, Peters, Mette A, Therien, Alex G, Boie, Yves, Crackower, Michael A
Published in Respiratory research (12.10.2012)
Published in Respiratory research (12.10.2012)
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Journal Article
Advances toward structure-based drug discovery for inflammasome targets
Wang, Li, Crackower, Michael A., Wu, Hao
Published in The Journal of experimental medicine (03.01.2022)
Published in The Journal of experimental medicine (03.01.2022)
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Journal Article
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system
St. Pierre, Cristina, Guo, Jane, Shin, John D., Engstrom, Laura W., Lee, Hyun-Hee, Herbert, Alan, Surdi, Laura, Baker, James, Salmon, Michael, Shah, Sanjiv, Ellis, J. Michael, Houshyar, Hani, Crackower, Michael A., Kleinschek, Melanie A., Jones, Dallas C., Hicks, Alexandra, Zaller, Dennis M., Alves, Stephen E., Ramadas, Ravisankar A.
Published in PloS one (18.07.2017)
Published in PloS one (18.07.2017)
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Journal Article
New insights into the noncanonical inflammasome point to caspase-4 as a druggable target
Elkayam, Elad, Gervais, Francois G., Wu, Hao, Crackower, Michael A., Lieberman, Judy
Published in Nature reviews. Immunology (01.08.2025)
Published in Nature reviews. Immunology (01.08.2025)
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Journal Article
Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis
Crackower, Michael A., Kolas, Nadine K., Noguchi, Junko, Sarao, Renu, Kikuchi, Kazuhiro, Kaneko, Hiroyuki, Kobayashi, Eiji, Kawai, Yasuhiro, Kozieradzki, Ivona, Landers, Rushin, Mo, Rong, Hui, Chi-Chung, Nieves, Edward, Cohen, Paula E., Osborne, Lucy R., Wada, Teiji, Kunieda, Tetsuo, Moens, Peter B., Penninger, Josef M.
Published in Science (American Association for the Advancement of Science) (23.05.2003)
Published in Science (American Association for the Advancement of Science) (23.05.2003)
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Journal Article
Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia
Nieuwenhuis, Erica, Motoyama, Jun, Barnfield, Paul C., Yoshikawa, Yoshiaki, Zhang, Xiaoyun, Mo, Rong, Crackower, Michael A., Hui, Chi-chung
Published in Molecular and Cellular Biology (01.09.2006)
Published in Molecular and Cellular Biology (01.09.2006)
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Journal Article
The Use of Strictly Standardized Mean Difference for Hit Selection in Primary RNA Interference High-Throughput Screening Experiments
Zhang, Xiaohua Douglas, Ferrer, Marc, Espeseth, Amy S., Marine, Shane Douglas, Stec, Erica M., Crackower, Michael A., Holder, Daniel J., Heyse, Joseph F., Strulovici, Berta
Published in SLAS discovery (01.06.2007)
Published in SLAS discovery (01.06.2007)
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Journal Article
Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X–Y defective male-specific sterility
Kolas, Nadine K., Marcon, Edyta, Crackower, Michael A., Höög, Christer, Penninger, Josef M., Spyropoulos, Barbara, Moens, Peter B.
Published in Chromosoma (01.07.2005)
Published in Chromosoma (01.07.2005)
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Journal Article
Inhibition of α v β 5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury
McCurley, Amy, Alimperti, Stella, Campos-Bilderback, Silvia B, Sandoval, Ruben M, Calvino, Jenna E, Reynolds, Taylor L, Quigley, Catherine, Mugford, Joshua W, Polacheck, William J, Gomez, Ivan G, Dovey, Jennifer, Marsh, Graham, Huang, Angela, Qian, Fang, Weinreb, Paul H, Dolinski, Brian M, Moore, Shaun, Duffield, Jeremy S, Chen, Christopher S, Molitoris, Bruce A, Violette, Shelia M, Crackower, Michael A
Published in Journal of the American Society of Nephrology (01.06.2017)
Published in Journal of the American Society of Nephrology (01.06.2017)
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Journal Article
Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices
Koziol‐White, Cynthia J, Jia, Yanlin, Baltus, Gretchen A, Cooper, Philip R, Zaller, Dennis M, Crackower, Michael A, Sirkowski, Erich E, Smock, Steven, Northrup, Alan B, Himes, Blanca E, Alves, Stephen E, Panettieri, Reynold A
Published in British journal of pharmacology (01.11.2016)
Published in British journal of pharmacology (01.11.2016)
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Journal Article