Vyzkoušejte nový nástroj s podporou AI
Summon Research Assistant
BETA
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
Shukla, Shirish, Ying, Weijiang, Gray, Felicia, Yao, Yiwu, Simes, Miranda L., Zhao, Qingjie, Miao, Hongzhi, Cho, Hyo Je, González-Alonso, Paula, Winkler, Alyssa, Lund, George, Purohit, Trupta, Kim, EunGi, Zhang, Xiaotian, Ray, Joshua M., He, Shihan, Nikolaidis, Caroline, Ndoj, Juliano, Wang, Jingya, Jaremko, Łukasz, Jaremko, Mariusz, Ryan, Russell J. H., Guzman, Monica L., Grembecka, Jolanta, Cierpicki, Tomasz
Published in Nature chemical biology (01.07.2021)
Published in Nature chemical biology (01.07.2021)
Get full text
Journal Article
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
Klossowski, Szymon, Miao, Hongzhi, Kempinska, Katarzyna, Wu, Tao, Purohit, Trupta, Kim, EunGi, Linhares, Brian M., Chen, Dong, Jih, Gloria, Perkey, Eric, Huang, Huang, He, Miao, Wen, Bo, Wang, Yi, Yu, Ke, Lee, Stanley Chun-Wei, Danet-Desnoyers, Gwenn, Trotman, Winifred, Kandarpa, Malathi, Cotton, Anitria, Abdel-Wahab, Omar, Lei, Hongwei, Dou, Yali, Guzman, Monica, Peterson, Luke, Gruber, Tanja, Choi, Sarah, Sun, Duxin, Ren, Pingda, Li, Lian-Sheng, Liu, Yi, Burrows, Francis, Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta
Published in The Journal of clinical investigation (01.02.2020)
Published in The Journal of clinical investigation (01.02.2020)
Get full text
Journal Article
Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
Wang, Xue Qing David, Fan, Dandan, Han, Qinyu, Liu, Yiman, Miao, Hongzhi, Wang, Xinyu, Li, Qinglan, Chen, Dong, Gore, Haley, Himadewi, Pamela, Pfeifer, Gerd P., Cierpicki, Tomasz, Grembecka, Jolanta, Su, Jianzhong, Chong, Shasha, Wan, Liling, Zhang, Xiaotian
Published in Cancer discovery (01.03.2023)
Published in Cancer discovery (01.03.2023)
Get full text
Journal Article
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity
Rogawski, David S., Deng, Jing, Li, Hao, Miao, Hongzhi, Borkin, Dmitry, Purohit, Trupta, Song, Jiho, Chase, Jennifer, Li, Shuangjiang, Ndoj, Juliano, Klossowski, Szymon, Kim, EunGi, Mao, Fengbiao, Zhou, Bo, Ropa, James, Krotoska, Marta Z., Jin, Zhuang, Ernst, Patricia, Feng, Xiaomin, Huang, Gang, Nishioka, Kenichi, Kelly, Samantha, He, Miao, Wen, Bo, Sun, Duxin, Muntean, Andrew, Dou, Yali, Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta
Published in Nature communications (14.05.2021)
Published in Nature communications (14.05.2021)
Get full text
Journal Article
Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma
Kempinska, Katarzyna, Malik, Bhavna, Borkin, Dmitry, Klossowski, Szymon, Shukla, Shirish, Miao, Hongzhi, Wang, Jingya, Cierpicki, Tomasz, Grembecka, Jolanta
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
Get full text
Journal Article
Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo
Borkin, Dmitry, He, Shihan, Miao, Hongzhi, Kempinska, Katarzyna, Pollock, Jonathan, Chase, Jennifer, Purohit, Trupta, Malik, Bhavna, Zhao, Ting, Wang, Jingya, Wen, Bo, Zong, Hongliang, Jones, Morgan, Danet-Desnoyers, Gwenn, Guzman, Monica L., Talpaz, Moshe, Bixby, Dale L., Sun, Duxin, Hess, Jay L., Muntean, Andrew G., Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta
Published in Cancer cell (13.04.2015)
Published in Cancer cell (13.04.2015)
Get full text
Journal Article
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G, Sorenson, Roderick J, Showalter, Hollis D, Murai, Marcelo J, Belcher, Amalia M, Hartley, Thomas, Hess, Jay L, Cierpicki, Tomasz
Published in Nature chemical biology (29.01.2012)
Published in Nature chemical biology (29.01.2012)
Get full text
Journal Article
Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial
Wang, Eunice S, Issa, Ghayas C, Erba, Harry P, Altman, Jessica K, Montesinos, Pau, DeBotton, Stephane, Walter, Roland B, Pettit, Kristen, Savona, Michael R, Shah, Mithun Vinod, Kremyanskaya, Marina, Baer, Maria R, Foran, James M, Schiller, Gary, Adès, Lionel, Heiblig, Mael, Berthon, Celine, Peterlin, Pierre, Rodríguez-Arbolí, Eduardo, Salamero, Olga, Patnaik, Mrinal M, Papayannidis, Cristina, Grembecka, Jolanta, Cierpicki, Tomasz, Clegg, Bradley, Ray, Joshua, Linhares, Brian M, Nie, Kun, Mitra, Amitava, Ahsan, Julie Mackey, Tabachri, Marilyn, Soifer, Harris S, Corum, Daniel, Leoni, Mollie, Dale, Stephen, Fathi, Amir T
Published in The lancet oncology (01.10.2024)
Published in The lancet oncology (01.10.2024)
Get full text
Journal Article
A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
Abulwerdi, Fardokht, Liao, Chenzhong, Liu, Meilan, Azmi, Asfar S., Aboukameel, Amro, Mady, Ahmed S.A., Gulappa, Thippeswamy, Cierpicki, Tomasz, Owens, Scott, Zhang, Tao, Sun, Duxin, Stuckey, Jeanne A., Mohammad, Ramzi M., Nikolovska-Coleska, Zaneta
Published in Molecular cancer therapeutics (01.03.2014)
Published in Molecular cancer therapeutics (01.03.2014)
Get full text
Journal Article
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma
Cardenas, Mariano G., Yu, Wenbo, Beguelin, Wendy, Teater, Matthew R., Geng, Huimin, Goldstein, Rebecca L., Oswald, Erin, Hatzi, Katerina, Yang, Shao-Ning, Cohen, Joanna, Shaknovich, Rita, Vanommeslaeghe, Kenno, Cheng, Huimin, Liang, Dongdong, Cho, Hyo Je, Abbott, Joshua, Tam, Wayne, Du, Wei, Leonard, John P., Elemento, Olivier, Cerchietti, Leandro, Cierpicki, Tomasz, Xue, Fengtian, MacKerell, Alexander D., Melnick, Ari M.
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
Get full text
Journal Article
Unexpected specificity within dynamic transcriptional protein–protein complexes
Henley, Matthew J., Linhares, Brian M., Morgan, Brittany S., Cierpicki, Tomasz, Fierke, Carol A., Mapp, Anna K.
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2020)
Get full text
Journal Article
Increased slow dynamics defines ligandability of BTB domains
Kharchenko, Vladlena, Linhares, Brian M., Borregard, Megan, Czaban, Iwona, Grembecka, Jolanta, Jaremko, Mariusz, Cierpicki, Tomasz, Jaremko, Łukasz
Published in Nature communications (16.11.2022)
Published in Nature communications (16.11.2022)
Get full text
Journal Article
Targeting the MLL complex in castration-resistant prostate cancer
Malik, Rohit, Khan, Amjad P, Asangani, Irfan A, Cieślik, Marcin, Prensner, John R, Wang, Xiaoju, Iyer, Matthew K, Jiang, Xia, Borkin, Dmitry, Escara-Wilke, June, Stender, Rachell, Wu, Yi-Mi, Niknafs, Yashar S, Jing, Xiaojun, Qiao, Yuanyuan, Palanisamy, Nallasivam, Kunju, Lakshmi P, Krishnamurthy, Pranathi M, Yocum, Anastasia K, Mellacheruvu, Dattatreya, Nesvizhskii, Alexey I, Cao, Xuhong, Dhanasekaran, Saravana M, Feng, Felix Y, Grembecka, Jolanta, Cierpicki, Tomasz, Chinnaiyan, Arul M
Published in Nature medicine (01.04.2015)
Published in Nature medicine (01.04.2015)
Get full text
Journal Article
An Ash2L/RbBP5 Heterodimer Stimulates the MLL1 Methyltransferase Activity through Coordinated Substrate Interactions with the MLL1 SET Domain
Cao, Fang, Chen, Yong, Cierpicki, Tomasz, Liu, Yifan, Basrur, Venkatesha, Lei, Ming, Dou, Yali
Published in PloS one (23.11.2010)
Published in PloS one (23.11.2010)
Get full text
Journal Article
BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization
Gray, Felicia, Cho, Hyo Je, Shukla, Shirish, He, Shihan, Harris, Ashley, Boytsov, Bohdan, Jaremko, Łukasz, Jaremko, Mariusz, Demeler, Borries, Lawlor, Elizabeth R., Grembecka, Jolanta, Cierpicki, Tomasz
Published in Nature communications (09.11.2016)
Published in Nature communications (09.11.2016)
Get full text
Journal Article
SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation
Wagner, Ryan T., Hlady, Ryan A., Pan, Xiaoyu, Wang, Liguo, Kim, Sungho, Zhao, Xia, El Khoury, Louis Y., Shaikh, Shafiq, Zhong, Jian, Lee, Jeong-Heon, Grembecka, Jolanta, Cierpicki, Tomasz, Ho, Thai H., Robertson, Keith D.
Published in Genome Biology (05.02.2025)
Published in Genome Biology (05.02.2025)
Get full text
Journal Article
GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode
Cho, Hyo Je, Li, Hao, Linhares, Brian M, Kim, EunGi, Ndoj, Juliano, Miao, Hongzhi, Grembecka, Jolanta, Cierpicki, Tomasz
Published in ACS chemical biology (21.09.2018)
Published in ACS chemical biology (21.09.2018)
Get full text
Journal Article
Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes
Kittan, Nicolai A., Allen, Ronald M., Dhaliwal, Abhay, Cavassani, Karen A., Schaller, Matthew, Gallagher, Katherine A., Carson, William F., Mukherjee, Sumanta, Grembecka, Jolanta, Cierpicki, Tomasz, Jarai, Gabor, Westwick, John, Kunkel, Steven L., Hogaboam, Cory M.
Published in PloS one (21.10.2013)
Published in PloS one (21.10.2013)
Get full text
Journal Article