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Crystal structure of an HIV assembly and maturation switch
Wagner, Jonathan M, Zadrozny, Kaneil K, Chrustowicz, Jakub, Purdy, Michael D, Yeager, Mark, Ganser-Pornillos, Barbie K, Pornillos, Owen
Published in eLife (14.07.2016)
Published in eLife (14.07.2016)
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Journal Article
Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly
Qiao, Shuai, Langlois, Christine R., Chrustowicz, Jakub, Sherpa, Dawafuti, Karayel, Ozge, Hansen, Fynn M., Beier, Viola, von Gronau, Susanne, Bollschweiler, Daniel, Schäfer, Tillman, Alpi, Arno F., Mann, Matthias, Prabu, J. Rajan, Schulman, Brenda A.
Published in Molecular cell (02.01.2020)
Published in Molecular cell (02.01.2020)
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Journal Article
Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
Qiao, Shuai, Lee, Chia-Wei, Sherpa, Dawafuti, Chrustowicz, Jakub, Cheng, Jingdong, Duennebacke, Maximilian, Steigenberger, Barbara, Karayel, Ozge, Vu, Duc Tung, von Gronau, Susanne, Mann, Matthias, Wilfling, Florian, Schulman, Brenda A.
Published in Nature communications (01.06.2022)
Published in Nature communications (01.06.2022)
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Journal Article
Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation
Sherpa, Dawafuti, Mueller, Judith, Karayel, Özge, Xu, Peng, Yao, Yu, Chrustowicz, Jakub, Gottemukkala, Karthik V, Baumann, Christine, Gross, Annette, Czarnecki, Oliver, Zhang, Wei, Gu, Jun, Nilvebrant, Johan, Sidhu, Sachdev S, Murray, Peter J, Mann, Matthias, Weiss, Mitchell J, Schulman, Brenda A, Alpi, Arno F
Published in eLife (02.12.2022)
Published in eLife (02.12.2022)
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Journal Article
MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat
Purdy, Michael D., Shi, Dan, Chrustowicz, Jakub, Hattne, Johan, Gonen, Tamir, Yeager, Mark
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2018)
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Journal Article
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
Sherpa, Dawafuti, Chrustowicz, Jakub, Qiao, Shuai, Langlois, Christine R., Hehl, Laura A., Gottemukkala, Karthik Varma, Hansen, Fynn M., Karayel, Ozge, von Gronau, Susanne, Prabu, J. Rajan, Mann, Matthias, Alpi, Arno F., Schulman, Brenda A.
Published in Molecular cell (03.06.2021)
Published in Molecular cell (03.06.2021)
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Journal Article
Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR 26 impair CTLH E 3 complex assembly
Gross, Annette, Müller, Judith, Chrustowicz, Jakub, Strasser, Alexander, Gottemukkala, Karthik V., Sherpa, Dawafuti, Schulman, Brenda A., Murray, Peter J., Alpi, Arno F.
Published in FEBS letters (01.05.2024)
Published in FEBS letters (01.05.2024)
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Journal Article
Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases
Chrustowicz, Jakub, Sherpa, Dawafuti, Teyra, Joan, Loke, Mun Siong, Popowicz, Grzegorz M., Basquin, Jerome, Sattler, Michael, Prabu, J. Rajan, Sidhu, Sachdev S., Schulman, Brenda A.
Published in Journal of molecular biology (30.01.2022)
Published in Journal of molecular biology (30.01.2022)
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Journal Article
Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR26 impair CTLH E3 complex assembly
Gross, Annette, Müller, Judith, Chrustowicz, Jakub, Strasser, Alexander, Gottemukkala, Karthik V., Sherpa, Dawafuti, Schulman, Brenda A., Murray, Peter J., Alpi, Arno F.
Published in FEBS letters (01.05.2024)
Published in FEBS letters (01.05.2024)
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Journal Article
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
Gottemukkala, Karthik V., Chrustowicz, Jakub, Sherpa, Dawafuti, Sepic, Sara, Vu, Duc Tung, Karayel, Özge, Papadopoulou, Eleftheria C., Gross, Annette, Schorpp, Kenji, von Gronau, Susanne, Hadian, Kamyar, Murray, Peter J., Mann, Matthias, Schulman, Brenda A., Alpi, Arno F.
Published in Molecular cell (16.05.2024)
Published in Molecular cell (16.05.2024)
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Journal Article
Fate of platinum metals in the environment
Pawlak, Justyna, Łodyga-Chruścińska, Elżbieta, Chrustowicz, Jakub
Published in Journal of trace elements in medicine and biology (01.07.2014)
Published in Journal of trace elements in medicine and biology (01.07.2014)
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Journal Article
Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies
Chrustowicz, Jakub, Sherpa, Dawafuti, Li, Jerry, Langlois, Christine R., Papadopoulou, Eleftheria C., Vu, D. Tung, Hehl, Laura A., Karayel, Özge, Beier, Viola, von Gronau, Susanne, Müller, Judith, Prabu, J. Rajan, Mann, Matthias, Kleiger, Gary, Alpi, Arno F., Schulman, Brenda A.
Published in Molecular cell (18.01.2024)
Published in Molecular cell (18.01.2024)
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Journal Article
Microdeletion in Chromosome 17 Cytoband q21.31 Identified As Located within the KANSL1 Gene Prevailed in Flt3-ITD Negative Normal Karyotype AML Patients As Opposed to Their AML Counterparts and Influenced the Phenotype of the Disease
Jaskula, Emilia, Lange, Andrzej, Sedzimirska, Mariola, Chrustowicz, Jakub, Tarnowska, Agnieszka, Lange, Janusz
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Charged Molecular Glue Discovery Enabled by Targeted Degron Display
Zhuang, Zhe, Byun, Woong Sub, Chrustowicz, Jakub, Kozicka, Zuzanna, Li, Veronica L., Abeja, Dinah M., Donovan, Katherine A., Sepic, Sara, You, Inchul, Słabicki, Mikołaj, Fischer, Eric S., Hinshaw, Stephen M., Ebert, Benjamin L., Schulman, Brenda A., Gray, Nathanael S.
Published in bioRxiv (26.09.2024)
Published in bioRxiv (26.09.2024)
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Paper
Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
Chrustowicz, Jakub, Sherpa, Dawafuti, Teyra, Joan, Loke, Mun Siong, Popowicz, Grzegorz, Basquin, Jerome, Sattler, Michael, J Rajan Prabu, Sidhu, Sachdev S, Schulman, Brenda A
Published in bioRxiv (04.09.2021)
Published in bioRxiv (04.09.2021)
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Paper
GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
Sherpa, Dawafuti, Chrustowicz, Jakub, Qiao, Shuai, Langlois, Christine R., Hehl, Laura A., Gottemukkala, Karthik Varma, Hansen, Fynn M., Karayel, Ozge, von Gronau, Susanne, Prabu, J. Rajan, Mann, Matthias, Alpi, Arno F., Schulman, Brenda A.
Published in bioRxiv (09.04.2021)
Published in bioRxiv (09.04.2021)
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Paper
Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation
Sherpa, Dawafuti, Müller, Judith, Karayel, Özge, Chrustowicz, Jakub, Xu, Peng, Gottemukkala, Karthik V., Baumann, Christine, Gross, Annette, Czarnezki, Oliver, Zhang, Wei, Gu, Jun, Nilvebrant, Johan, Weiss, Mitchell J., Sidhu, Sachdev S., Murray, Peter J., Mann, Matthias, Schulman, Brenda A., Alpi, Arno F.
Published in bioRxiv (18.01.2022)
Published in bioRxiv (18.01.2022)
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Paper