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AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
Saito, Yusuke, Chapple, Richard H., Lin, Angelique, Kitano, Ayumi, Nakada, Daisuke
Published in Cell stem cell (05.11.2015)
Published in Cell stem cell (05.11.2015)
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Journal Article
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma
Pan, Min, Wright, William C., Chapple, Richard H., Zubair, Asif, Sandhu, Manbir, Batchelder, Jake E., Huddle, Brandt C., Low, Jonathan, Blankenship, Kaley B., Wang, Yingzhe, Gordon, Brittney, Archer, Payton, Brady, Samuel W., Natarajan, Sivaraman, Posgai, Matthew J., Schuetz, John, Miller, Darcie, Kalathur, Ravi, Chen, Siquan, Connelly, Jon Patrick, Babu, M. Madan, Dyer, Michael A., Pruett-Miller, Shondra M., Freeman, Burgess B., Chen, Taosheng, Godley, Lucy A., Blanchard, Scott C., Stewart, Elizabeth, Easton, John, Geeleher, Paul
Published in Nature communications (09.11.2021)
Published in Nature communications (09.11.2021)
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Journal Article
An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs
Chapple, Richard H., Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I. M., Kim, Yuna, Patel, Anand G., LaFlamme, Christy W., Pan, Min, Wright, William C., Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C., Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D., Confer, Thomas, Akers, Walter J., Dyer, Michael A., Sheppard, Heather, Easton, John, Geeleher, Paul
Published in Genome Biology (19.06.2024)
Published in Genome Biology (19.06.2024)
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Journal Article
A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics
Lee, Hyeong-Min, Wright, William C., Pan, Min, Low, Jonathan, Currier, Duane, Fang, Jie, Singh, Shivendra, Nance, Stephanie, Delahunty, Ian, Kim, Yuna, Chapple, Richard H., Zhang, Yinwen, Liu, Xueying, Steele, Jacob A., Qi, Jun, Pruett-Miller, Shondra M., Easton, John, Chen, Taosheng, Yang, Jun, Durbin, Adam D., Geeleher, Paul
Published in Nature communications (13.11.2023)
Published in Nature communications (13.11.2023)
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Journal Article
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Pan, Min, Zhang, Yinwen, Wright, William C., Liu, Xueying, Passaia, Barbara, Currier, Duane, Low, Jonathan, Chapple, Richard H., Steele, Jacob A., Connelly, Jon P., Ju, Bensheng, Plyler, Emily, Lu, Meifen, Loughran, Allister J., Yang, Lei, Abraham, Brian J., Pruett-Miller, Shondra M., Freeman, Burgess, Campbell, George E., Dyer, Michael A., Chen, Taosheng, Stewart, Elizabeth, Koo, Selene, Sheppard, Heather, Easton, John, Geeleher, Paul
Published in Nature communications (28.02.2025)
Published in Nature communications (28.02.2025)
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Journal Article
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
Grzeskowiak, Caitlin L., Kundu, Samrat T., Mo, Xiulei, Ivanov, Andrei A., Zagorodna, Oksana, Lu, Hengyu, Chapple, Richard H., Tsang, Yiu Huen, Moreno, Daniela, Mosqueda, Maribel, Eterovic, Karina, Fradette, Jared J., Ahmad, Sumreen, Chen, Fengju, Chong, Zechen, Chen, Ken, Creighton, Chad J., Fu, Haian, Mills, Gordon B., Gibbons, Don L., Scott, Kenneth L.
Published in Nature communications (16.07.2018)
Published in Nature communications (16.07.2018)
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Journal Article
ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response
Chapple, Richard H, Hu, Tianyuan, Tseng, Yu-Jung, Liu, Lu, Kitano, Ayumi, Luu, Victor, Hoegenauer, Kevin A, Iwawaki, Takao, Li, Qing, Nakada, Daisuke
Published in eLife (16.02.2018)
Published in eLife (16.02.2018)
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Journal Article
Accuracies of genomic breeding values in American Angus beef cattle using K-means clustering for cross-validation
Saatchi, Mahdi, McClure, Mathew C, McKay, Stephanie D, Rolf, Megan M, Kim, JaeWoo, Decker, Jared E, Taxis, Tasia M, Chapple, Richard H, Ramey, Holly R, Northcutt, Sally L, Bauck, Stewart, Woodward, Brent, Dekkers, Jack CM, Fernando, Rohan L, Schnabel, Robert D, Garrick, Dorian J, Taylor, Jeremy F
Published in Genetics selection evolution (Paris) (28.11.2011)
Published in Genetics selection evolution (Paris) (28.11.2011)
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Journal Article
Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis
Chapple, Richard H., Tseng, Yu-Jung, Hu, Tianyuan, Kitano, Ayumi, Takeichi, Makiko, Hoegenauer, Kevin A., Nakada, Daisuke
Published in Blood advances (12.06.2018)
Published in Blood advances (12.06.2018)
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Journal Article
Characterization of the rat developmental liver transcriptome
Chapple, Richard H., Tizioto, Polyana C., Wells, Kevin D., Givan, Scott A., Kim, JaeWoo, McKay, Stephanie D., Schnabel, Robert D., Taylor, Jeremy F.
Published in Physiological genomics (15.04.2013)
Published in Physiological genomics (15.04.2013)
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Journal Article
Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics
Takahashi, Munetomo, Barile, Melania, Chapple, Richard H, Tseng, Yu-Jung, Nakada, Daisuke, Busch, Katrin, Fanti, Ann-Kathrin, Säwén, Petter, Bryder, David, Höfer, Thomas, Göttgens, Berthold
Published in Stem Cell Reports (01.04.2021)
Published in Stem Cell Reports (01.04.2021)
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Journal Article
Cell type identification in spatial transcriptomics data can be improved by leveraging cell-type-informative paired tissue images using a Bayesian probabilistic model
Zubair, Asif, Chapple, Richard H, Natarajan, Sivaraman, Wright, William C, Pan, Min, Lee, Hyeong-Min, Tillman, Heather, Easton, John, Geeleher, Paul
Published in Nucleic acids research (12.08.2022)
Published in Nucleic acids research (12.08.2022)
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Journal Article
CSI-GEP: A GPU-based unsupervised machine learning approach for recovering gene expression programs in atlas-scale single-cell RNA-seq data
Liu, Xueying, Chapple, Richard H, Bennett, Declan, Wright, William C, Sanjali, Ankita, Culp, Erielle, Zhang, Yinwen, Pan, Min, Geeleher, Paul
Published in Cell genomics (08.01.2025)
Published in Cell genomics (08.01.2025)
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Journal Article
Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics
Takahashi, Munetomo, Barile, Melania, Chapple, Richard H., Tseng, Yu-jung, Nakada, Daisuke, Busch, Katrin, Fanti, Ann-Kathrin, Säwén, Petter, Bryder, David, Höfer, Thomas, Göttgens, Berthold
Published in Stem cell reports (13.04.2021)
Published in Stem cell reports (13.04.2021)
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Journal Article
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Pan, Min, Zhang, Yinwen, Wright, William C, Liu, Xueying, Passaia, Barbara, Currier, Duane, Low, Jonathan, Chapple, Richard H, Steele, Jacob A, Connelly, Jon P, Lu, Meifen, Lee, Hyeong-Min, Loughran, Allister J, Yang, Lei, Abraham, Brian J, Pruett-Miller, Shondra M, Freeman, Burgess, Campbell, George E, Dyer, Michael A, Chen, Taosheng, Stewart, Elizabeth, Koo, Selene, Sheppard, Heather, Easton, John, Geeleher, Paul
Published in bioRxiv (14.05.2024)
Published in bioRxiv (14.05.2024)
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Paper
An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs
Chapple, Richard H, Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I M, Kim, Yuna, Patel, Anand G, LaFlamme, Christy W, Pan, Min, Wright, William C, Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C, Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D, Confer, Thomas, Akers, Walter J, Dyer, Michael A, Sheppard, Heather, Easton, John, Geeleher, Paul
Published in bioRxiv (22.04.2024)
Published in bioRxiv (22.04.2024)
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Journal Article
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A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity
Patel, Anand G, Ashenberg, Orr, Collins, Natalie B, Segerstolpe, Åsa, Jiang, Sizun, Slyper, Michal, Huang, Xin, Caraccio, Chiara, Jin, Hongjian, Sheppard, Heather, Xu, Ke, Chang, Ti-Cheng, Orr, Brent A, Shirinifard, Abbas, Chapple, Richard H, Shen, Amber, Clay, Michael R, Tatevossian, Ruth G, Reilly, Colleen, Patel, Jaimin, Lupo, Marybeth, Cline, Cynthia, Dionne, Danielle, Porter, Caroline B M, Waldman, Julia, Bai, Yunhao, Zhu, Bokai, Barrera, Irving, Murray, Evan, Vigneau, Sébastien, Napolitano, Sara, Wakiro, Isaac, Wu, Jingyi, Grimaldi, Grace, Dellostritto, Laura, Helvie, Karla, Rotem, Asaf, Lako, Ana, Cullen, Nicole, Pfaff, Kathleen L, Karlström, Åsa, Jané-Valbuena, Judit, Todres, Ellen, Thorner, Aaron, Geeleher, Paul, Rodig, Scott J, Zhou, Xin, Stewart, Elizabeth, Johnson, Bruce E, Wu, Gang, Chen, Fei, Yu, Jiyang, Goltsev, Yury, Nolan, Garry P, Rozenblatt-Rosen, Orit, Regev, Aviv, Dyer, Michael A
Published in bioRxiv (16.01.2024)
Published in bioRxiv (16.01.2024)
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Journal Article
Paper
Cell type identification in spatial transcriptomics data can be improved by leveraging cell-type-informative paired tissue images using a Bayesian probabilistic model
Zubair, Asif, Chapple, Richard H, Sivaraman Natarajan, Wright, William C, Pan, Min, Lee, Hyeong-Min, Tillman, Heather, Easton, John, Geeleher, Paul
Published in bioRxiv (13.04.2022)
Published in bioRxiv (13.04.2022)
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Paper
Abstract B005: BMP signaling determines neuroblastoma sensitivity to retinoic acid by directing cell fate
Pan, Min, Zhang, Yinwen, Wright, William C., Lee, Hyeong-Min, Chapple, Richard H., Liu, Xueying, Low, Jonathan, Currier, Duane, Loughran, Allister J., Dyer, Michael A., Pruett, Shondra M., Freeman, Burgess, Chen, Taosheng, Abraham, Brian J., Stewart, Elizabeth, Easton, John, Geeleher, Paul
Published in Cancer research (Chicago, Ill.) (05.09.2024)
Published in Cancer research (Chicago, Ill.) (05.09.2024)
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Journal Article
Abstract 151: BMP signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Pan, Min, Zhang, Yinwen, Wright, William C., Lee, Hyeong-Min, Chapple, Richard H., Liu, Xueying, Low, Jonathan, Currier, Duane, Loughran, Allister J., Dyer, Dyer A., Pruett, Shondra M., Freeman, Burgess, Chen, Taosheng, Abraham, Brian J., Stewart, Elizabeth, Easton, John, Geeleher, Paul
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article